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Database: UniProt
Entry: M7AI37_CHEMY
LinkDB: M7AI37_CHEMY
Original site: M7AI37_CHEMY 
ID   M7AI37_CHEMY            Unreviewed;       830 AA.
AC   M7AI37;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=UY3_18932 {ECO:0000313|EMBL:EMP23989.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP23989.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB604211; EMP23989.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 3.
DR   Pfam; PF01496; V_ATPase_I; 3.
DR   PIRSF; PIRSF001293; ATP6V0A1; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    461    485       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    506    524       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    559    583       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    595    611       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    631    649       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    762    786       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       51     78       {ECO:0000256|SAM:Coils}.
FT   COILED       93    127       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   830 AA;  95296 MW;  35E56956783637C5 CRC64;
     MASMFRSEEM CLMQLFLQVE AAYCCVAELG ELGLVQFRDL NVNVNSFQRK FVNEVRRCES
     LERILRFLEN EMENEIVIFK PEKYPETPLP REMIDLETVL EKLESELQEA NQNQQTLKQN
     FLELTELKHL LKKTQDFFET ETNLPDDFFN EDTSGLLELR STPTAVAAKL GVVHVQKYLK
     YACHLSVLLT LPRFTAGVIK RERMVPFERL LWRACRGNIY LRYTEMDTSL EDPITKEQMK
     KNVFIIFYQG EQLNQKIKKI CDGFRATVYT CPESATERRE MSDGVNTRIE DLNAVITQTE
     SHRQRLLCEA AANLWTWGIK VKKIKAIYHI LNCCNIDITQ QCVIAEIWFP VADSGKIKRA
     LQQGMERSGS TISPILTAVQ SKMAPPTFNR TNKFTAGFQN IVDAYGVGSY REMNPGKKTR
     ALLQPEDEIL PRAWVKGEGL RSLTILCDPK PPPYTIITFP FLFAVMFGDC GHGAVMLGFA
     LWMVANEKTL LAQKSNNEIW NTFFGGRYLI LLMGIFSIYT GFIYNDCFSK SFNIFGSSWH
     TRPMFRNNTW NYFKKTINIV LQFIPEMIFI LCLFGYLVFM IIFKWCRFDV HVSQKAPSIL
     IHFINMFLFN YNDPTNGPLY PHQEEVQSFL VIFALIAVPW MLLFKPFILR ANHRKAQRML
     QTPAISENPA GDTEVEIIDS NHAKKAGQED HSGGHAGHDH DEEFSFGDTF VHQAIHTIEY
     CLGCISNTAS YLRLWALSLA HAQLSEVLWT MVMNIGLKNS GWGGLIGVFI IFAIFAVLTV
     AILLVMEGLS AFLHALRLHW VEFQNKFYVG TGYKFSPFCF KSIIDGTTED
//
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