GenomeNet

Database: UniProt
Entry: M7AT62_CHEMY
LinkDB: M7AT62_CHEMY
Original site: M7AT62_CHEMY 
ID   M7AT62_CHEMY            Unreviewed;      3262 AA.
AC   M7AT62;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 52.
DE   SubName: Full=Putative E3 ubiquitin-protein ligase HERC1 {ECO:0000313|EMBL:EMP26120.1};
GN   ORFNames=UY3_16799 {ECO:0000313|EMBL:EMP26120.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC   Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26120.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA   White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA   Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA   Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA   Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT   into the development and evolution of the turtle-specific body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC       feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; KB583439; EMP26120.1; -; Genomic_DNA.
DR   STRING; 8469.M7AT62; -.
DR   eggNOG; KOG1426; Eukaryota.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR   CDD; cd00078; HECTc; 1.
DR   CDD; cd12881; SPRY_HERC1; 1.
DR   CDD; cd14401; UBA_HERC1; 1.
DR   Gene3D; 2.60.120.920; -; 1.
DR   Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR   Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR   Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR   Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR043136; B30.2/SPRY_sf.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR000569; HECT_dom.
DR   InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR   InterPro; IPR044822; Myb_DNA-bind_4.
DR   InterPro; IPR009091; RCC1/BLIP-II.
DR   InterPro; IPR000408; Reg_chr_condens.
DR   InterPro; IPR003877; SPRY_dom.
DR   InterPro; IPR035768; SPRY_HERC1.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   InterPro; IPR019775; WD40_repeat_CS.
DR   InterPro; IPR036322; WD40_repeat_dom_sf.
DR   InterPro; IPR001680; WD40_rpt.
DR   PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR   PANTHER; PTHR22872:SF6; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER 1; 1.
DR   Pfam; PF00632; HECT; 1.
DR   Pfam; PF13837; Myb_DNA-bind_4; 1.
DR   Pfam; PF00415; RCC1; 5.
DR   Pfam; PF00622; SPRY; 1.
DR   Pfam; PF00400; WD40; 3.
DR   PRINTS; PR00633; RCCNDNSATION.
DR   SMART; SM00119; HECTc; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SMART; SM00320; WD40; 4.
DR   SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR   SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR   SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR   SUPFAM; SSF50978; WD40 repeat-like; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
DR   PROSITE; PS50237; HECT; 1.
DR   PROSITE; PS00626; RCC1_2; 1.
DR   PROSITE; PS50012; RCC1_3; 7.
DR   PROSITE; PS00678; WD_REPEATS_1; 1.
DR   PROSITE; PS50082; WD_REPEATS_2; 3.
DR   PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679};
KW   Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW   ECO:0000256|PROSITE-ProRule:PRU00104};
KW   WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW   ProRule:PRU00221}.
FT   DOMAIN          258..449
FT                   /note="B30.2/SPRY"
FT                   /evidence="ECO:0000259|PROSITE:PS50188"
FT   REPEAT          1666..1707
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          1879..1920
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          2008..2049
FT                   /note="WD"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT   REPEAT          2262..2310
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2311..2365
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2366..2417
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2418..2454
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2452..2503
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2504..2555
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   REPEAT          2556..2607
FT                   /note="RCC1"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT   DOMAIN          2747..3083
FT                   /note="HECT"
FT                   /evidence="ECO:0000259|PROSITE:PS50237"
FT   REGION          511..542
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          654..703
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          864..923
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          940..1000
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1046..1124
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1476..1495
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3223..3249
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          3128..3155
FT                   /evidence="ECO:0000256|SAM:Coils"
FT   COMPBIAS        654..684
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        870..917
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        940..991
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1058..1081
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1476..1492
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3262 AA;  358472 MW;  497DBCE78C783623 CRC64;
     MTCAIKNFSE DNETISTSEN RDVDRTEAIL PDEGTKGMDE IELNMDAAAQ WVNDPSLILP
     TWLHEDDSEV QLMRCGIHSL QLIWDGLNKE HAKKFLAKIR QGNGEDDAFE KELDKQQRCR
     RVSAIHNYNE ALFERNFRED CEAIEPIAAL RKQHAAELHL GDFLVFLRRV VSSKAIQSKM
     ASPKWTEVLL NIASQKCCSG VPLVGNLRTR LLALHVLEAV LPACESGVED DQMAQVVERL
     FSLLSDCMWE TPIAQAKYAI QIKEREQEMK LQKQGETEEE DENLPIQEVS FDPEKAQCCI
     VENGQILTHG SGGKGYGLAS TGVTSGCYQW KFYIVKENRG NEGTCVGVSR WPVHDFNHRT
     TSDMWLYRAY SGNLYHNGEQ TLTLSSFTQG DFITCVLDME ARTISFGKNG EEPKLAFEDV
     DAAELYPCVM FYSSNPGEKV KICDMQMRGT PRDLLPGDPI CSPVAAVLAE ATIQLIRILH
     RADRWTHCIN KKMMERLHKI KMCLKEAGQK LKKSRSVQSR DENDMREEKE NKEEEKNKHS
     RHGLADLPEL QLKTLCVEVW PVLAVIGGVD AGLRVGGRCV HKQTGRHATL LGVVKEGSTS
     AKVQWDEAEI TISDTPLYNL EPCEPLPFDV ARFRGLTATV LLDLTYLTGI HEDTGKQSAK
     RHEKKHRHET EDKGDIEQKT EGDAGSDMRS LPSADDIKGP ITTCSKSENE IASFSLEPTL
     LGMESQHQPI EGKRKNHEHI PRNHDVVQSE IRAVQLSYLY LGAMKSLSAL LSCSKYAELL
     LIPKVLAENG HNSDCASSPV VHEDVEMRAA LQFLMRHMVK RAVMRSPIKR ALGLADLERA
     QAMIYKLVVH GLLEDQFGGK IKQEVDQQAE ESEQAQQAQT PVTTSPSASS TTSFMSSSLE
     DTTTATTPVT DTETVPASES PGVMPLSLLR QMFSSYPTTT VLPTRRAQTP PISSLPTSPS
     DEVGRRQSLT SPDSQSTRPA NRTALSDPSS RLSTSPPPPA IAVPLLEMGF SLRQIAKAME
     ATGARGEADA QNITVLAMWM IEHPGNEEDE EPQSEGTADS HHGTIVSGSS GKSSDQCYLQ
     SPGDIPSADA TEMEEGFSES PDNMDHAENA ASGSGPPSRG RSAVTRRHKF DLAARTLLAR
     AVQAHRNQSR REGISLQQDP GALYDFNLDE ELEIDLDDEA MEAMFGQDLA TDNDILGMWI
     PEVLDWPTWH VCESEDREEV VVCELCESSV VSFNQHMKRN HPGCGRSANR QGYRSNGSYV
     DGWFGGECGS GNPYYLLCGS CREKYLALKS KSKTSTSERY KGQAPDLIGK QDSVYEEDWD
     MLDVDEDEKL TGEEEFELLA GPLGLNDRRI VPEAVQFPDS DPLGASVAMV TATNSMEETL
     MQIGCHGSIE KSSSGRITLG EQAAALVNPH DRVMALRRVT AAAQVLLART MVMRALSLLS
     VSGSSCSLAA GLESLGLTDI RTLVRLMCLA AAGRAGLSTS PSTMSSSTER SRGVHSKTSK
     PISCLAYLST AVGCLASNTP SAAKLLVQLC TQNLISAATG VNLTTVDDPI QRKFLPSFLR
     GIAEENKLVT SPNFVVTQAL VALLADKGAK LRPNYDKAEI EKKGPLELAN ALAACCLSSR
     LSSQHRQWAA QQLVRTLAAH DRDNQISPQT LADMGGDLRK CSFIKLEAHQ NRVMTCVWCN
     KKGLLATSGN DGTIRVWNVT KKQYSLQQTC VFNKLEGDSE ESLGSPSDPS LSLICWSISG
     KYLAGALEKT VNIWQVNGGK GLLDLQPHWV SALAWPEEGP TATWTGDAPE VLLVGRMDGS
     LGLIEVIDVS TMHRLELEHC YRKDGRGCQN GLVCVWSVPQ DMLSVLQSSS SSAEGWWEQE
     TSGKDGYRKA VDAKCIYQLR GHITPVRTLA FSSDGLVLVS GGLGGLMNIW SLRDGSVLQS
     VVIGSGAIQT AVWIPDVGVA ACSNRSKVLL YIKVLGCQNG LVCVWSVPQD MLIVLQSSSS
     SAEGWWEQET SGKDGYRKAV DAKCIYQLRG HITPVRTLAF SSDGLVLVSG GLGGLMNIWS
     LRDGSVLQSV VIGSGAIQTA VWIPDVGVAA CSNRSKDVLV VNCTSEWISS NHVLATCRTA
     LKQQGVLGLN MAPCMRAFLE RLPIMLQEQY AYEKPHVVCG DQLVHSPYMQ CLASLAVGLH
     LDQLLCNPPI PPHHQNCLPD PSAWNPTEWA WLECFSTTIK AAEALAKGAQ FPESFTVPDL
     EPVPEDELIL LMDNSKWING MDEQIMSWAT SRPEDWHLGG KCDVYLWGAG RHGQLAEAGR
     NVMIPVAAPS FSQAQQVICG QNCTFVIQAN GTVLACGEGS YGRLGQGNSD DLHVLTVISA
     LQGFVVTQLV TSCGSDGHSM ALTESGEVFS WGDGDYGKLG HGNSDRQRRP RQIEALQGEE
     VAQMSCGFKH SAVVTADGKL FTFGNGDYGR LGLGNTSNKK LPERVTALED GSMVWAFGDG
     DYGKLGLGNS TAKSSPQKVD ILCGIGIKRV ACGTQFSVAL TKGGHVYTFG QDRLIGLPEG
     RARNHNRPQQ VPVLSGIFIE DIAVGAEHTL ALSSSGDVYA WGSNSEGQLG LGHTNHVREP
     TLITVLQGKN IRQISAGRCH SAAWTAPPVP PRAPGVSVPL QLGLPDAIPP QYGALKEVSI
     HTVRARLRLL YHFSDLMYSS WRLLNLSPNN QNSTSHYNAG TWGIVQGQLR PLLAPRVYTL
     PMVRSIGKTM VQGKNYGPQI TVKRISTRGR KCKPIFVQIA RQVVKLNASD LRLPSRAWKV
     KLVGEGADDA GGVFDDTITE MCQELETGVV DLLIPSPNAT AEVGYNRDRF LFNSSACLDE
     HLMQFKFLGI LMGVAIRTKK PLDLHLAPMV WKQLCCIPLT LEDLEEVDLL YVQTLNSILH
     IEDSGITEEN FHEMIPLDSF VGQSADGKMV PIIPGGNSIP LTFSNRKEYV ERAIEYRLHE
     IDRQVAAVRE GMSWIVPVPL LSLLTAKQLE QMVCGMPEIS VEVLKKVVRY REVDEQHQLV
     QWFWHTLEEF SNEERVLFMR FVSGRSRLPA NTADISQRFQ IMKVDREVSH DAYHDRSGQQ
     LELCCPEVPT ACSQLIVPAL RSRHVPAWST PELLDLLSIW GEEALQLHLC TSRRNFDTYE
     LIASGIQEKQ HERNMQQCHA KIERLRQAYQ KAKEASRYFG VVPKTCHPRR RPHLDRQELH
     RYFWGTGGSR LNPSEEVLDA EMALDDDVEH MAGSSGDAAS QDLVSTLEGS SQSQHSSSST
     QDAGEGSSVT IGLHQQYLDC MR
//
DBGET integrated database retrieval system