ID M7AT62_CHEMY Unreviewed; 3262 AA.
AC M7AT62;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=Putative E3 ubiquitin-protein ligase HERC1 {ECO:0000313|EMBL:EMP26120.1};
GN ORFNames=UY3_16799 {ECO:0000313|EMBL:EMP26120.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP26120.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00104}.
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DR EMBL; KB583439; EMP26120.1; -; Genomic_DNA.
DR STRING; 8469.M7AT62; -.
DR eggNOG; KOG1426; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR CDD; cd12881; SPRY_HERC1; 1.
DR CDD; cd14401; UBA_HERC1; 1.
DR Gene3D; 2.60.120.920; -; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 1.10.10.60; Homeodomain-like; 1.
DR Gene3D; 2.130.10.30; Regulator of chromosome condensation 1/beta-lactamase-inhibitor protein II; 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR001870; B30.2/SPRY.
DR InterPro; IPR043136; B30.2/SPRY_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR InterPro; IPR044822; Myb_DNA-bind_4.
DR InterPro; IPR009091; RCC1/BLIP-II.
DR InterPro; IPR000408; Reg_chr_condens.
DR InterPro; IPR003877; SPRY_dom.
DR InterPro; IPR035768; SPRY_HERC1.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR019775; WD40_repeat_CS.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR22872; BTK-BINDING PROTEIN-RELATED; 1.
DR PANTHER; PTHR22872:SF6; HECT AND RLD DOMAIN CONTAINING E3 UBIQUITIN PROTEIN LIGASE FAMILY MEMBER 1; 1.
DR Pfam; PF00632; HECT; 1.
DR Pfam; PF13837; Myb_DNA-bind_4; 1.
DR Pfam; PF00415; RCC1; 5.
DR Pfam; PF00622; SPRY; 1.
DR Pfam; PF00400; WD40; 3.
DR PRINTS; PR00633; RCCNDNSATION.
DR SMART; SM00119; HECTc; 1.
DR SMART; SM00449; SPRY; 1.
DR SMART; SM00320; WD40; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR SUPFAM; SSF50985; RCC1/BLIP-II; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50188; B302_SPRY; 1.
DR PROSITE; PS50237; HECT; 1.
DR PROSITE; PS00626; RCC1_2; 1.
DR PROSITE; PS50012; RCC1_3; 7.
DR PROSITE; PS00678; WD_REPEATS_1; 1.
DR PROSITE; PS50082; WD_REPEATS_2; 3.
DR PROSITE; PS50294; WD_REPEATS_REGION; 3.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574, ECO:0000256|PROSITE-
KW ProRule:PRU00221}.
FT DOMAIN 258..449
FT /note="B30.2/SPRY"
FT /evidence="ECO:0000259|PROSITE:PS50188"
FT REPEAT 1666..1707
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 1879..1920
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2008..2049
FT /note="WD"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00221"
FT REPEAT 2262..2310
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2311..2365
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2366..2417
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2418..2454
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2452..2503
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2504..2555
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT REPEAT 2556..2607
FT /note="RCC1"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00235"
FT DOMAIN 2747..3083
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT REGION 511..542
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 654..703
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 864..923
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..1000
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1046..1124
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1476..1495
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3223..3249
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 3128..3155
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 654..684
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 870..917
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 940..991
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1058..1081
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1476..1492
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3262 AA; 358472 MW; 497DBCE78C783623 CRC64;
MTCAIKNFSE DNETISTSEN RDVDRTEAIL PDEGTKGMDE IELNMDAAAQ WVNDPSLILP
TWLHEDDSEV QLMRCGIHSL QLIWDGLNKE HAKKFLAKIR QGNGEDDAFE KELDKQQRCR
RVSAIHNYNE ALFERNFRED CEAIEPIAAL RKQHAAELHL GDFLVFLRRV VSSKAIQSKM
ASPKWTEVLL NIASQKCCSG VPLVGNLRTR LLALHVLEAV LPACESGVED DQMAQVVERL
FSLLSDCMWE TPIAQAKYAI QIKEREQEMK LQKQGETEEE DENLPIQEVS FDPEKAQCCI
VENGQILTHG SGGKGYGLAS TGVTSGCYQW KFYIVKENRG NEGTCVGVSR WPVHDFNHRT
TSDMWLYRAY SGNLYHNGEQ TLTLSSFTQG DFITCVLDME ARTISFGKNG EEPKLAFEDV
DAAELYPCVM FYSSNPGEKV KICDMQMRGT PRDLLPGDPI CSPVAAVLAE ATIQLIRILH
RADRWTHCIN KKMMERLHKI KMCLKEAGQK LKKSRSVQSR DENDMREEKE NKEEEKNKHS
RHGLADLPEL QLKTLCVEVW PVLAVIGGVD AGLRVGGRCV HKQTGRHATL LGVVKEGSTS
AKVQWDEAEI TISDTPLYNL EPCEPLPFDV ARFRGLTATV LLDLTYLTGI HEDTGKQSAK
RHEKKHRHET EDKGDIEQKT EGDAGSDMRS LPSADDIKGP ITTCSKSENE IASFSLEPTL
LGMESQHQPI EGKRKNHEHI PRNHDVVQSE IRAVQLSYLY LGAMKSLSAL LSCSKYAELL
LIPKVLAENG HNSDCASSPV VHEDVEMRAA LQFLMRHMVK RAVMRSPIKR ALGLADLERA
QAMIYKLVVH GLLEDQFGGK IKQEVDQQAE ESEQAQQAQT PVTTSPSASS TTSFMSSSLE
DTTTATTPVT DTETVPASES PGVMPLSLLR QMFSSYPTTT VLPTRRAQTP PISSLPTSPS
DEVGRRQSLT SPDSQSTRPA NRTALSDPSS RLSTSPPPPA IAVPLLEMGF SLRQIAKAME
ATGARGEADA QNITVLAMWM IEHPGNEEDE EPQSEGTADS HHGTIVSGSS GKSSDQCYLQ
SPGDIPSADA TEMEEGFSES PDNMDHAENA ASGSGPPSRG RSAVTRRHKF DLAARTLLAR
AVQAHRNQSR REGISLQQDP GALYDFNLDE ELEIDLDDEA MEAMFGQDLA TDNDILGMWI
PEVLDWPTWH VCESEDREEV VVCELCESSV VSFNQHMKRN HPGCGRSANR QGYRSNGSYV
DGWFGGECGS GNPYYLLCGS CREKYLALKS KSKTSTSERY KGQAPDLIGK QDSVYEEDWD
MLDVDEDEKL TGEEEFELLA GPLGLNDRRI VPEAVQFPDS DPLGASVAMV TATNSMEETL
MQIGCHGSIE KSSSGRITLG EQAAALVNPH DRVMALRRVT AAAQVLLART MVMRALSLLS
VSGSSCSLAA GLESLGLTDI RTLVRLMCLA AAGRAGLSTS PSTMSSSTER SRGVHSKTSK
PISCLAYLST AVGCLASNTP SAAKLLVQLC TQNLISAATG VNLTTVDDPI QRKFLPSFLR
GIAEENKLVT SPNFVVTQAL VALLADKGAK LRPNYDKAEI EKKGPLELAN ALAACCLSSR
LSSQHRQWAA QQLVRTLAAH DRDNQISPQT LADMGGDLRK CSFIKLEAHQ NRVMTCVWCN
KKGLLATSGN DGTIRVWNVT KKQYSLQQTC VFNKLEGDSE ESLGSPSDPS LSLICWSISG
KYLAGALEKT VNIWQVNGGK GLLDLQPHWV SALAWPEEGP TATWTGDAPE VLLVGRMDGS
LGLIEVIDVS TMHRLELEHC YRKDGRGCQN GLVCVWSVPQ DMLSVLQSSS SSAEGWWEQE
TSGKDGYRKA VDAKCIYQLR GHITPVRTLA FSSDGLVLVS GGLGGLMNIW SLRDGSVLQS
VVIGSGAIQT AVWIPDVGVA ACSNRSKVLL YIKVLGCQNG LVCVWSVPQD MLIVLQSSSS
SAEGWWEQET SGKDGYRKAV DAKCIYQLRG HITPVRTLAF SSDGLVLVSG GLGGLMNIWS
LRDGSVLQSV VIGSGAIQTA VWIPDVGVAA CSNRSKDVLV VNCTSEWISS NHVLATCRTA
LKQQGVLGLN MAPCMRAFLE RLPIMLQEQY AYEKPHVVCG DQLVHSPYMQ CLASLAVGLH
LDQLLCNPPI PPHHQNCLPD PSAWNPTEWA WLECFSTTIK AAEALAKGAQ FPESFTVPDL
EPVPEDELIL LMDNSKWING MDEQIMSWAT SRPEDWHLGG KCDVYLWGAG RHGQLAEAGR
NVMIPVAAPS FSQAQQVICG QNCTFVIQAN GTVLACGEGS YGRLGQGNSD DLHVLTVISA
LQGFVVTQLV TSCGSDGHSM ALTESGEVFS WGDGDYGKLG HGNSDRQRRP RQIEALQGEE
VAQMSCGFKH SAVVTADGKL FTFGNGDYGR LGLGNTSNKK LPERVTALED GSMVWAFGDG
DYGKLGLGNS TAKSSPQKVD ILCGIGIKRV ACGTQFSVAL TKGGHVYTFG QDRLIGLPEG
RARNHNRPQQ VPVLSGIFIE DIAVGAEHTL ALSSSGDVYA WGSNSEGQLG LGHTNHVREP
TLITVLQGKN IRQISAGRCH SAAWTAPPVP PRAPGVSVPL QLGLPDAIPP QYGALKEVSI
HTVRARLRLL YHFSDLMYSS WRLLNLSPNN QNSTSHYNAG TWGIVQGQLR PLLAPRVYTL
PMVRSIGKTM VQGKNYGPQI TVKRISTRGR KCKPIFVQIA RQVVKLNASD LRLPSRAWKV
KLVGEGADDA GGVFDDTITE MCQELETGVV DLLIPSPNAT AEVGYNRDRF LFNSSACLDE
HLMQFKFLGI LMGVAIRTKK PLDLHLAPMV WKQLCCIPLT LEDLEEVDLL YVQTLNSILH
IEDSGITEEN FHEMIPLDSF VGQSADGKMV PIIPGGNSIP LTFSNRKEYV ERAIEYRLHE
IDRQVAAVRE GMSWIVPVPL LSLLTAKQLE QMVCGMPEIS VEVLKKVVRY REVDEQHQLV
QWFWHTLEEF SNEERVLFMR FVSGRSRLPA NTADISQRFQ IMKVDREVSH DAYHDRSGQQ
LELCCPEVPT ACSQLIVPAL RSRHVPAWST PELLDLLSIW GEEALQLHLC TSRRNFDTYE
LIASGIQEKQ HERNMQQCHA KIERLRQAYQ KAKEASRYFG VVPKTCHPRR RPHLDRQELH
RYFWGTGGSR LNPSEEVLDA EMALDDDVEH MAGSSGDAAS QDLVSTLEGS SQSQHSSSST
QDAGEGSSVT IGLHQQYLDC MR
//