ID M7B044_CHEMY Unreviewed; 1087 AA.
AC M7B044;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Proto-oncogene tyrosine-protein kinase receptor Ret {ECO:0000313|EMBL:EMP28765.1};
DE Flags: Fragment;
GN ORFNames=UY3_14151 {ECO:0000313|EMBL:EMP28765.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP28765.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + L-tyrosyl-[protein] = ADP + H(+) + O-phospho-L-tyrosyl-
CC [protein]; Xref=Rhea:RHEA:10596, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620, ChEBI:CHEBI:456216; EC=2.7.10.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001171};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
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DR EMBL; KB560900; EMP28765.1; -; Genomic_DNA.
DR AlphaFoldDB; M7B044; -.
DR STRING; 8469.M7B044; -.
DR eggNOG; KOG0200; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005509; F:calcium ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004713; F:protein tyrosine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0007156; P:homophilic cell adhesion via plasma membrane adhesion molecules; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd11304; Cadherin_repeat; 2.
DR CDD; cd05045; PTKc_RET; 1.
DR Gene3D; 2.60.40.60; Cadherins; 2.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR002126; Cadherin-like_dom.
DR InterPro; IPR015919; Cadherin-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041163; Ret_CLD1.
DR InterPro; IPR040667; Ret_CLD3.
DR InterPro; IPR041317; RET_CLD4.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008266; Tyr_kinase_AS.
DR InterPro; IPR020635; Tyr_kinase_cat_dom.
DR InterPro; IPR016249; Tyr_kinase_Ret_rcpt.
DR PANTHER; PTHR24416:SF485; PROTO-ONCOGENE TYROSINE-PROTEIN KINASE RECEPTOR RET; 1.
DR PANTHER; PTHR24416; TYROSINE-PROTEIN KINASE RECEPTOR; 1.
DR Pfam; PF00028; Cadherin; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF17756; RET_CLD1; 1.
DR Pfam; PF17812; RET_CLD3; 1.
DR Pfam; PF17813; RET_CLD4; 1.
DR PIRSF; PIRSF000631; TyrPK_receptor_Ret; 1.
DR PRINTS; PR00205; CADHERIN.
DR PRINTS; PR00109; TYRKINASE.
DR SMART; SM00112; CA; 1.
DR SMART; SM00219; TyrKc; 1.
DR SUPFAM; SSF49313; Cadherin-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50268; CADHERIN_2; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00109; PROTEIN_KINASE_TYR; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Calcium {ECO:0000256|PROSITE-ProRule:PRU00043};
KW Kinase {ECO:0000313|EMBL:EMP28765.1};
KW Nucleotide-binding {ECO:0000256|PROSITE-ProRule:PRU10141};
KW Receptor {ECO:0000313|EMBL:EMP28765.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transferase {ECO:0000256|ARBA:ARBA00023137};
KW Tyrosine-protein kinase {ECO:0000256|ARBA:ARBA00023137}.
FT DOMAIN 141..245
FT /note="Cadherin"
FT /evidence="ECO:0000259|PROSITE:PS50268"
FT DOMAIN 697..989
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT ACT_SITE 847
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000631-1"
FT BINDING 731
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
FT CARBOHYD 124
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR000631-4"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP28765.1"
FT NON_TER 1087
FT /evidence="ECO:0000313|EMBL:EMP28765.1"
SQ SEQUENCE 1087 AA; 122870 MW; C6C973F1551D26A2 CRC64;
SFGLYFPRKD YSETVYIDQP AGTPLLHIRA LRDSHGEVAH FQLCQHLFIY RVGAYENHWF
QIKEKTGLLY LNKSLDRGDF DILFGRNWVS LPKVTFHVYL SSQPFQGKEC ETPISALVHL
SILNATVPAC NALTSRELCF SEMDLSFHIK ENKPPGTFHQ LQLPPIHHLC QNVSISYKLL
AVDGLPFRYN ENTTGVSVVQ RLDREERERY ELIAKCTVRE GSKEMQVEVP FLVNVLDEDD
SAPFLPNGTS TTDAVVEFNR KEGTVLATLT VCDADTTPIF PIESSRKKYT GTISTTDPWI
SETFRVDHIF HEIYFSPNGS QVRGTLHEYK LMLNKNISVT ENRSFQLDVL VNDTEFHGPE
RSVMLHFNVS ILPVSIQFPN VTYQFAVNRN AERFAQIGKI CIENCMKFCG VNITYRLLSP
SASCYAVGIL QGREDKYGSL YVNDSSVLLR PECKEIQYTI VASDKQSKKH AKTQLTITLE
GTVIKKEEDC PESCAVNKHR AECEECGGVG VLTGKCEWRQ GSGKGITTNY STCTPSIRTC
PDGTCDVIES KDPSVCPQDC TNGNIIGGHE RGAHGIKSGH GICYCFPRQN CYCEKDDIKE
PLCDDVCKTV IAGAVLLSFI ISVLLSSYFI HRYHKNSPKP PIASAEMTFR RPAQSYPISY
SSTNVRRPSL DSMENQVPVD TFKIPEDPKW EFPRKNLVLG KTLGEGEFGK VVKATAFRLK
GKAGYTTVAV KMLKENASQS ELRDLLSEFN LLKQVNHPHV IKLYGACSQD GPLYLIVEYA
KYGSLRSFLR ESRKVGPSYV GSDANRNSSY LDNPDERALT MGDLISFAWQ ISRGMQYLAE
MKLVHRDLAA RNVLVAEGRK MKISDFGLSR DVYEEDSYVK RSKGRIPVKW MAIESLFDHI
YTTQSDVWSF GVLLWEIVTL GGNPYPGIAP ERLFNLLKTG YRMERPENCS EEMYNLMLRC
WKQEPDKRPT FADISKELEK MMVKSRDYLD LAASTPADSL LYDDGLSEEE TPLVDCNNAP
LPRTLPSTWI ENKLYGMSYP NWPEESPVPL TRFDGTNSVF SRYANDSVYA NWMVSPSAAK
FMDKFDS
//
