ID M7B9X8_CHEMY Unreviewed; 2570 AA.
AC M7B9X8;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 44.
DE RecName: Full=Inositol 1,4,5-trisphosphate receptor {ECO:0000256|RuleBase:RU368044};
GN ORFNames=UY3_10562 {ECO:0000313|EMBL:EMP32350.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP32350.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- FUNCTION: Receptor for inositol 1,4,5-trisphosphate, a second messenger
CC that mediates the release of intracellular calcium.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|RuleBase:RU368044}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000256|ARBA:ARBA00004477, ECO:0000256|RuleBase:RU368044}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004477,
CC ECO:0000256|RuleBase:RU368044}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- DOMAIN: The receptor contains a calcium channel in its C-terminal
CC extremity. Its large N-terminal cytoplasmic region has the ligand-
CC binding site in the N-terminus and modulatory sites in the middle
CC portion immediately upstream of the channel region.
CC {ECO:0000256|RuleBase:RU368044}.
CC -!- SIMILARITY: Belongs to the InsP3 receptor family.
CC {ECO:0000256|ARBA:ARBA00009453, ECO:0000256|RuleBase:RU368044}.
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DR EMBL; KB540908; EMP32350.1; -; Genomic_DNA.
DR STRING; 8469.M7B9X8; -.
DR eggNOG; KOG3533; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0070679; F:inositol 1,4,5 trisphosphate binding; IEA:UniProtKB-UniRule.
DR GO; GO:0005220; F:inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051209; P:release of sequestered calcium ion into cytosol; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.80.10.50; -; 3.
DR Gene3D; 1.25.10.30; IP3 receptor type 1 binding core, RIH domain; 1.
DR InterPro; IPR014821; Ins145_P3_rcpt.
DR InterPro; IPR000493; InsP3_rcpt.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR036300; MIR_dom_sf.
DR InterPro; IPR016093; MIR_motif.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR000699; RIH_dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR035910; RyR/IP3R_RIH_dom_sf.
DR PANTHER; PTHR45816:SF1; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; 1.
DR PANTHER; PTHR45816; MIR DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF08709; Ins145_P3_rec; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF02815; MIR; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF01365; RYDR_ITPR; 2.
DR PRINTS; PR00779; INSP3RECEPTR.
DR SMART; SM00472; MIR; 3.
DR SUPFAM; SSF100909; IP3 receptor type 1 binding core, domain 2; 2.
DR SUPFAM; SSF82109; MIR domain; 1.
DR PROSITE; PS50919; MIR; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|RuleBase:RU368044};
KW Calcium channel {ECO:0000256|ARBA:ARBA00022673,
KW ECO:0000256|RuleBase:RU368044};
KW Calcium transport {ECO:0000256|ARBA:ARBA00022568,
KW ECO:0000256|RuleBase:RU368044}; Coiled coil {ECO:0000256|SAM:Coils};
KW Endoplasmic reticulum {ECO:0000256|ARBA:ARBA00022824,
KW ECO:0000256|RuleBase:RU368044};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303, ECO:0000256|RuleBase:RU368044};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU368044};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286,
KW ECO:0000256|RuleBase:RU368044};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU368044};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU368044};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU368044};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU368044};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU368044}.
FT TRANSMEM 2137..2162
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2174..2192
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2204..2224
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2260..2285
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2305..2327
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT TRANSMEM 2397..2420
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU368044"
FT DOMAIN 179..235
FT /note="MIR"
FT /evidence="ECO:0000259|PROSITE:PS50919"
FT REGION 1078..1109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1747..1771
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2528..2555
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 2570 AA; 294534 MW; F458E94F21DD2120 CRC64;
MNEMSSFLHI GDIVSLYAEG SVNGFISTLG LVDDRCVVEP AAGDLDNPPK KFRDCLFKVC
PMNRYSAQKQ YWKAKQTKQD KDKIADVVLL QKLQHAAQME QKQNDTENKK VHGDVVKYGS
VIQVVVGDKV ILNPVNAGQP LHASNYELAD NAGCKEVNSV NCNTSWKINL FMQFRDHMEE
VLKGGDVVRL FHAEQEKFLT CDEYKAKIHV FLRTTLRQSA TSATSSNALW EVEVVHHDPC
RGGAGHWNGL YRFKHLATGN YLAAEENPSY KGDAADPKSA PMGGTIRSSR RKTGEKIKYR
LVAVPHGNDI ASLFELDPTT LQKTDSFVPR NSYVRLRHLC TNTWIQSTDV PIDIDEERPI
RLMLGTCPTK EDKEAFAIVS VPVSEIRDLD FANDASSMLA NVVEKMNEGF ISQNDRRFVI
QLLEDLVFFV SDVPNNGQNV LDIMVTKPNR ERQKLMREQN ILKQIFGILK APFKEKGGEG
PLVRLEELSD QKNAPYQYMF RLCYRVLRHS QDDYRKNQEH IAKQFGMMQS QIGYDILAED
TITALLHNNR KLLEKHITKT EVETFVSLVR KNREPRFLDY LSDLCVSNHI AIPVTQELIC
KCVLDPKNSD ILIKTELRPV KEMSQTHEYL SIEYSEEEVW LTWSDKNNDS QEKSIRQLAQ
EARAGNAHDE NILSYYRYQL KLFARMCLDR QYLAIKEISK QLGVELIFLC MADEMLPFDL
RASFCHLMLH VHVDRDPQEL VMPVKFARLW TEIPTAITIK DYDSNLNDSR DDKKNKFAST
MEFVEDYLNN VVSEAVPFAN EEKNKLTFEV VSLAHNLIYF GFYSFSELLR LTRTLLGIID
CVQNPQLMMQ TMYNEDMAGK NVRKSIQGVG QMMSTMVLSR KQSIFSVPSL STVVASEPTD
RERTIENENI VVMETKLKIL EILQFILNVR LDYRISYLLS VFKKEFIEVY PMQDSSADGT
APAFDSTNAA MNLDRIGEQA EAMFGVGKSS SMLEVDDEGG RMFLRVLIHL TMHNYPPLVS
GSLQLLFKHF SQRQEVLHTF KQVQLLISAQ DVENYKVIKA ELDKLRMMVE KSELWVDKKG
SPKGEDAGEG AKKEKKEHTA DEEVSTPEEK SSENYKIVKG ILERLNKMCG VGEQVRKKQQ
RLMKNMDAHK VMLDLLQIPY EKGDAKMMEI LRYTHQFLQK FCAGNQGNQA LLHKHLNLFL
TPGAETMQHI FLNNYQLCSE ISETVLQHFV HCLATHGRHV QYLDFLHSII KAEGKYVKKC
QDMIMTELTN AGDDVVVFYN DKASLATMLE MMTAAREGVE ENSPLMYHIS LVDLLAACAE
GKNVYTEIKC TSLLPLEDIV QVVTHEDCIT EVKMAYVNFV NHCYVDTEVE MKEIYTSNHI
WTLFENFTLD MATMCKKREK RLTDPALEKY VLTVVLDTIN AFFSSPFSEN STSLQTHQTI
VVQLLQSTMR LLECSWLQQQ HKTSVEACIR TLAMVXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXXXX PVPRGPSLAL QVHARPGPNP DGIDIINSLE ERFKPLVEAE VSVLVDVLHR
PELLFMEGTD AYQRCESGGF LSKLVQHTKD LMESEEKLCI RVLRTLQQML MKRNKYGDRG
NTLRKMLVSN YLQNKKSSSK GEIVDTTGGG QDQDWSVIAA IQCRLDREGA TKLVSDLIMN
TKNEKIFQES ILLAIRLLDG GNTEIQKSFY NLMTSDKKCE KFFKVLHERM KKAQQETKSI
VSVNMTDIGN KPQEDKDTPD PGTKGRGTFM LSHAPSRHPM AIGFRKGHDT GERSQNNEMG
MSILIMEPIL RFLQLLCENH NRDLQNFLRC QNNKTNYNLV CETLQFLDIM CGSTTGGLGL
LGLYINECNV ALITQTLETL TEYCQGPCHE NQSCIVTHES NGIDIITALI LNEISPLCKY
RMDLVLQLKD NASKLLLALM ESRHDSENAA RILISLRPQE LVDVIKKAYL QEEECENSEI
SPREVGHNIY ILALQLSRHN KQLQHLLKPV KRIQEEEVEG ISSMLRLKNK QLTQMLKSTA
PIQEEEEDPL AYYEKHTSQI EIVRLDRSME QIIFPVPSIC EFVTRETKYR LFTTTEQDEQ
GSKVSDFFDQ SSFLHNEMEW QKKLRSMPLM YWFSRRMTLW GSISFNLAVF INIIIAFFYP
YVEATSMGVL DSPLISLLFW LLICFSIMAL FTRRYGVRPL LVALILRSIY YLGIGLTLNI
LGALNLTNKI VFVVSFVGNR GTFIRGYKAM IMDMEFLYHV AYIVTSILGL FVHELFYSIL
LFDLIYREET LFNVIKSVTR NGRSILLTAL LALILVYLFS IVGFLFLKDD FIMEVDRLPD
NKSKDDDDNS ERACDTLLMC IVTVLNHGLR NGGGVGDILR KPSKDESLFP ARVIYDLLFF
FIVIIIVLNL IFGVIIDTFA DLRSEKQKKE EILKTTCFIC GLERDKFDNK TVSFEEHIKY
EHNMWNYLYF IVLVRVKNKT DYTGPESYVA QMIKNMNLDW FPRMRAMSLV SNEGEGEQNE
IRSLQDKLNS TMKLVSHLTS QLNELKEQMT EQRKRRQRIG FVDAQNTMNH
//
