ID M7BC16_CHEMY Unreviewed; 442 AA.
AC M7BC16;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Arachidonate 12-lipoxygenase, 12R-type {ECO:0000313|EMBL:EMP29688.1};
GN ORFNames=UY3_13194 {ECO:0000313|EMBL:EMP29688.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP29688.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB554349; EMP29688.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BC16; -.
DR STRING; 8469.M7BC16; -.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016702; F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen; IEA:InterPro.
DR GO; GO:0034440; P:lipid oxidation; IEA:InterPro.
DR InterPro; IPR000907; LipOase.
DR InterPro; IPR013819; LipOase_C.
DR InterPro; IPR036226; LipOase_C_sf.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR PANTHER; PTHR11771; LIPOXYGENASE; 1.
DR PANTHER; PTHR11771:SF161; POLYUNSATURATED FATTY ACID LIPOXYGENASE ALOX15B; 1.
DR Pfam; PF00305; Lipoxygenase; 1.
DR Pfam; PF01477; PLAT; 1.
DR PRINTS; PR00087; LIPOXYGENASE.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR SUPFAM; SSF48484; Lipoxigenase; 2.
DR PROSITE; PS51393; LIPOXYGENASE_3; 1.
PE 4: Predicted;
KW Dioxygenase {ECO:0000256|ARBA:ARBA00022964};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 122..442
FT /note="Lipoxygenase"
FT /evidence="ECO:0000259|PROSITE:PS51393"
FT REGION 120..142
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 409..428
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 442 AA; 47429 MW; D0E77DE4A88FF062 CRC64;
MGVYKVRVAT GNFLLAGTFS SISITLVGTH EESDKKPLDN YGKDFNPGAV STSQTVCDDA
DSPWLLEQRQ AELKHRRECY GWKEYAPGLP RCLAVESIIE LDCNTMYSFT KSTNFLLRGG
NAPPLRSDPP HAGPVSPESR PSALTPRLWD WTLAKTWVRY AEFLVHEAVS HLLLTHLIGE
PFALATLRQL PLCHPVFKTA AVFHSNPPPG PVARRLKALS LVPSQGLGSG LEGTKVLMAK
GMSCLTYASL CFPDDIQERG VDCIPNYYYR DDGLKIWSAI ESPGCPGLLA EPDLPCAGAP
GRGEEGIPGW AWGGSWLGRG DWLGCGGPGC SDCGGLSGLQ YDLGAWMPNF PATMRNPPPQ
AKGTTSLESY LDTIPEVNST SLAIYILWVL CCEPGDSVRT RVPGGAVGQG MGRGLSRGCS
PPAGRAGSRA ALGGARRWVS VE
//
