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Database: UniProt
Entry: M7BFT6_CHEMY
LinkDB: M7BFT6_CHEMY
Original site: M7BFT6_CHEMY 
ID   M7BFT6_CHEMY            Unreviewed;      2035 AA.
AC   M7BFT6;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 34.
DE   SubName: Full=Sodium channel protein type 4 subunit alpha {ECO:0000313|EMBL:EMP27097.1};
GN   ORFNames=UY3_15817 {ECO:0000313|EMBL:EMP27097.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP27097.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|RuleBase:RU003618}.
CC   -!- SIMILARITY: Belongs to the somatotropin/prolactin family.
CC       {ECO:0000256|RuleBase:RU003618}.
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DR   EMBL; KB573777; EMP27097.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:InterPro.
DR   GO; GO:0005179; F:hormone activity; IEA:UniProtKB-KW.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   Gene3D; 2.60.40.10; -; 1.
DR   InterPro; IPR009079; 4_helix_cytokine-like_core.
DR   InterPro; IPR036179; Ig-like_dom_sf.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR001400; Somatotropin/Prolactin.
DR   InterPro; IPR018116; Somatotropin_CS.
DR   Pfam; PF00103; Hormone_1; 1.
DR   Pfam; PF00520; Ion_trans; 5.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00836; SOMATOTROPIN.
DR   SUPFAM; SSF47266; SSF47266; 1.
DR   SUPFAM; SSF48726; SSF48726; 1.
DR   PROSITE; PS00266; SOMATOTROPIN_1; 1.
DR   PROSITE; PS00338; SOMATOTROPIN_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Hormone {ECO:0000256|RuleBase:RU003618};
KW   Ion channel {ECO:0000313|EMBL:EMP27097.1};
KW   Ion transport {ECO:0000313|EMBL:EMP27097.1};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000313|EMBL:EMP27097.1}.
FT   SIGNAL        1     17       {ECO:0000256|SAM:SignalP}.
FT   CHAIN        18   2035       {ECO:0000256|SAM:SignalP}.
FT                                /FTId=PRO_5004080248.
FT   TRANSMEM    119    139       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    266    293       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    465    483       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    495    518       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    530    554       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    574    603       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    633    653       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    665    688       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    930    950       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    970    988       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1021   1041       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1131   1149       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1161   1179       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1186   1211       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1248   1276       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1349   1375       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN        1    300       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      466    692       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      702    925       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      929   1004       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1006   1115       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1130   1385       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      301    331       {ECO:0000256|SAM:Coils}.
FT   COILED     1950   1977       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2035 AA;  230406 MW;  0E047F7C80CF059D CRC64;
     MFIMITILTN CVFMTMSDPP PWAKNVEYTF TGIYTFESMI KIVARGFCID QFTFLRDPWN
     WLDFSVIVMA YTTEFVDLGN VSALRTFRVL RALKTITVIP GLKTIVGALV QSVKKLSDVM
     ILTVFCLSVF ALVGLQLFMG NLRQKCIRWP PPINDTLQED IFGMDNDMFA NSTLSSNTTG
     LSNGTFDWDS YINDEEEALP QEQLQHILGL SREELFEAPL HPGEMAAAEL ASESEEAEAT
     GKPVTQAHAA SLTSGAQTLR AAGKTYMIFF VVVIFLGSFY LINLILAVVA MAYAEQNDAT
     MLEEQQREAE FQQLLEQLKK HQEEQEKLLR DRKSSGISQS SSALNKKMGD SAPAAADNQG
     KSKDCNGRVI ASVVLERSAT PSPVDKQDKS DPDHLLAGGQ NGPGLQQRAD SAVSMISNTM
     EELEEARQKC PPWWYKFAQT FLVWDCCPLW LKLKAFIRLI VMDPFVDLGI TICIVLNTLF
     MAMEHYPMTE EFENVLSVGN LVFTGIFTAE MVLKLIALDP YDYFQQGWNI FDSIIVTLSL
     VELGLANVQG LSVLRSFRLL RVFKLAKSWP TLNMLIKIIG NSVGALGNLT LVLAIIVFIF
     AVVGMQLFGK SYKEYVCKIS LDCTLPRWHM YDFFHAFLII FRILCGEWIE TMWDCMEVAG
     QPMCLIVFLM VMVIGNLVVL NLFLALLLSS FSADSLAASD DDGELNNLQI AIGRITRAID
     FVKRTVLTLL HLQWKEKREP AEEQEDNKKD NYVLNHMDSG QDSKSEYMDG VAGKEQLFVD
     ELDHMNFINN PNLTVHVPIA SEESDLYDEE TSTQSDTEDT KGAERRERRA GPWGEEAKQG
     WSHGAEWARR VHSLWARGST SSLCSTVDYK APEVEAEEAA DEAAEGQGPE ECFTEACVRR
     FPFLYVDITT DKGKIWWNLR KTCFKIVEHN WFETFIIFMI LLSSGALAFE DIYIEQRKVI
     RTILEYADKI FSYVFVLEML LKWVAYGFKV YFTNAWCWLD FLIVDVVVNA LLGAIPSIMN
     VLLVCLIFWL IFSIMGVNLF AGKYYRCINT TTDELFDISE VNNKSDCLAL LHTNQVRWVN
     VKVNFDNVGL GYLSLLQVAT FKGWMDIMYA AVDSRENKCQ GLVFDFVTKQ AFDIIIMVLI
     CLNMVTMMVE TDDQSPTKIN ILYNINMIFI VVFTGECLLK MFALRYYYFT IGWNIFDFVV
     VILSIGGIVL SDIIEKYFVS PTLFRVIRLA RIGRVLRLIR GAKGIRTLLF ALMMSLPALF
     NIGLLLFLVM FIYSIFGMSN FAYVKKESGI DDIFNFETFG NSIICLFQIT TSAGWDGLLN
     PILNSGPPDC DPDLENPGSS VKGDCGNPSI GICFFCTYII ISFLIVVNMY IAIILENFNV
     ATEESSEPLC EDDFEMFYET WEKFDPDATQ FIAYSVLSDF VDTLQEPLKI AKPNKIKLIT
     MDLPMVVGDK IHCLDILFAL TKEVLGDSGE MDGLKATMEE KFMAANPSKV SYEPITTTLK
     RKHEEVCAIK IQRAFRRLPC LLTVPENLQV KTFCLSRGQI YIDRKVLSCF AKALSFLALK
     KKPVGELAAF LQPQRKAGAL MFSCHFISEM ASPCKSLAAL RTQLWLLVLI TGEISASRNS
     SPRNSDMFCS NFRQHPRYIA AKKNTQVHFI CHSRNSADVQ WYKMTGHDKT PQMINMNDPR
     VNENRSESFV MITFSKIQPE DNGIYLCENK SLARDLGRIR TCGSELRVIG FSTIKQVQRR
     NSVKDIIIMI QSILLVIFVS VPMLLLLEKG DGKASSDEDH TYEGLEIEQT ATYEDIAPLR
     DVKAKWTVGE HPGQEACDSF KGSYFSPLLF AAIILGLQWP QGAAAFPAMP LSSLFANAVL
     RAQHLHLLAA DTYKEFERTY IPEEQRHSNK ISQSAFCYSE TIPAPTGKDD AQQKSDMELL
     RFSLILIQSW LNPVQFLSRV FTNSLVFGTS DRVYEKLRDL EEGIQALMRE LEDGSLRGFQ
     VLRPTYDKFD INLRNEDALL KNYGLLSCFK KDLHKVETYL KLMKCRRFGE SNCTI
//
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