ID M7BIQ1_CHEMY Unreviewed; 449 AA.
AC M7BIQ1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=Monocarboxylate transporter 2 {ECO:0000256|ARBA:ARBA00015820};
DE AltName: Full=Solute carrier family 16 member 7 {ECO:0000256|ARBA:ARBA00029783};
DE Flags: Fragment;
GN ORFNames=UY3_10961 {ECO:0000313|EMBL:EMP31923.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP31923.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(R)-3-hydroxybutanoate(out) + H(+)(out) = (R)-3-
CC hydroxybutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71795,
CC ChEBI:CHEBI:10983, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000256|ARBA:ARBA00034273};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-3-hydroxybutanoate(out) + H(+)(out) = (S)-3-
CC hydroxybutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71871,
CC ChEBI:CHEBI:11047, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000256|ARBA:ARBA00034262};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=(S)-lactate(in) + H(+)(in) = (S)-lactate(out) + H(+)(out);
CC Xref=Rhea:RHEA:29415, ChEBI:CHEBI:15378, ChEBI:CHEBI:16651;
CC Evidence={ECO:0000256|ARBA:ARBA00034245};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=3-methyl-2-oxobutanoate(out) + H(+)(out) = 3-methyl-2-
CC oxobutanoate(in) + H(+)(in); Xref=Rhea:RHEA:71783, ChEBI:CHEBI:11851,
CC ChEBI:CHEBI:15378; Evidence={ECO:0000256|ARBA:ARBA00034218};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=4-methyl-2-oxopentanoate(out) + H(+)(out) = 4-methyl-2-
CC oxopentanoate(in) + H(+)(in); Xref=Rhea:RHEA:71779,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17865;
CC Evidence={ECO:0000256|ARBA:ARBA00034216};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H(+)(out) + pyruvate(out) = H(+)(in) + pyruvate(in);
CC Xref=Rhea:RHEA:64720, ChEBI:CHEBI:15361, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000256|ARBA:ARBA00034229};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:64721;
CC Evidence={ECO:0000256|ARBA:ARBA00034229};
CC PhysiologicalDirection=right-to-left; Xref=Rhea:RHEA:64722;
CC Evidence={ECO:0000256|ARBA:ARBA00034229};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=acetoacetate(out) + H(+)(out) = acetoacetate(in) + H(+)(in);
CC Xref=Rhea:RHEA:71775, ChEBI:CHEBI:13705, ChEBI:CHEBI:15378;
CC Evidence={ECO:0000256|ARBA:ARBA00034277};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Cytoplasm
CC {ECO:0000256|ARBA:ARBA00004496}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KB543130; EMP31923.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BIQ1; -.
DR STRING; 8469.M7BIQ1; -.
DR eggNOG; KOG2504; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008028; F:monocarboxylic acid transmembrane transporter activity; IEA:InterPro.
DR CDD; cd17427; MFS_MCT2; 1.
DR Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR InterPro; IPR004743; MCT.
DR InterPro; IPR011701; MFS.
DR InterPro; IPR020846; MFS_dom.
DR InterPro; IPR036259; MFS_trans_sf.
DR NCBIfam; TIGR00892; 2A0113; 1.
DR PANTHER; PTHR11360; MONOCARBOXYLATE TRANSPORTER; 1.
DR PANTHER; PTHR11360:SF25; MONOCARBOXYLATE TRANSPORTER 2; 1.
DR Pfam; PF07690; MFS_1; 1.
DR SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR PROSITE; PS50850; MFS; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 16..36
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 57..79
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 99..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 144..163
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 175..194
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 245..266
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 278..301
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 313..332
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..357
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 369..391
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 403..425
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 18..434
FT /note="Major facilitator superfamily (MFS) profile"
FT /evidence="ECO:0000259|PROSITE:PS50850"
FT NON_TER 449
FT /evidence="ECO:0000313|EMBL:EMP31923.1"
SQ SEQUENCE 449 AA; 48928 MW; B0CDD4478137F3B5 CRC64;
MPPATTAPQY APPDGGWGWV VVFGAFISIG FSYAFPKAIT VFFKEIQEIF HTSYSEIAWI
SSIMLAVMYA GGPISSVLVN KYGCRPVMMA GGVLCSFGMI ASSFCNSVLE LYVCVGIVGG
LGLAFNLQPA LTMIGKYFYK KRPIANGLAM AGSPVFLSTL APLNQFLFNA FGWKGSFLIL
GGLLLNCCVA GSLMRPVGPK PVPPVKKDVE KGSGDSALHM NNKKSSFWQT VNKYLDLSLF
KHRGFLVYLS GNVIMFVGFF APIVFLAPYA KHKGIDEYSA AFLLSILAFV DMFARPSMGL
VANSKYIRPK IQYFFSFAVL YNGICHIMCP LAEDYTGLVV YAVLFGFAFG MVSSILFESL
MDLVGAARFS SAVGLVTIVE CCPVLLGPPL GGWLVDITGD YKYMYIVCGS IVIVASIWLF
IGNAINYRLL AKEKNLEDKK QKALKKEAE
//
