ID M7BJ52_CHEMY Unreviewed; 2654 AA.
AC M7BJ52;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 30.
DE SubName: Full=Polycystic kidney disease and receptor for egg jelly-related protein {ECO:0000313|EMBL:EMP37219.1};
GN ORFNames=UY3_05590 {ECO:0000313|EMBL:EMP37219.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP37219.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the polycystin family.
CC {ECO:0000256|ARBA:ARBA00007200}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00152}.
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DR EMBL; KB522916; EMP37219.1; -; Genomic_DNA.
DR STRING; 8469.M7BJ52; -.
DR eggNOG; KOG3599; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd01752; PLAT_polycystin; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 2.60.60.20; PLAT/LH2 domain; 1.
DR InterPro; IPR002859; PKD/REJ-like.
DR InterPro; IPR013122; PKD1_2_channel.
DR InterPro; IPR003915; PKD_2.
DR InterPro; IPR001024; PLAT/LH2_dom.
DR InterPro; IPR036392; PLAT/LH2_dom_sf.
DR InterPro; IPR042060; PLAT_polycystin1.
DR InterPro; IPR046791; Polycystin_dom.
DR InterPro; IPR014010; REJ_dom.
DR PANTHER; PTHR10877:SF150; POLYCYSTIC KIDNEY DISEASE AND RECEPTOR FOR EGG JELLY-RELATED PROTEIN; 1.
DR PANTHER; PTHR10877; POLYCYSTIN FAMILY MEMBER; 1.
DR Pfam; PF08016; PKD_channel; 1.
DR Pfam; PF01477; PLAT; 1.
DR Pfam; PF20519; Polycystin_dom; 1.
DR Pfam; PF02010; REJ; 1.
DR PRINTS; PR01433; POLYCYSTIN2.
DR SMART; SM00308; LH2; 1.
DR SUPFAM; SSF49723; Lipase/lipooxygenase domain (PLAT/LH2 domain); 1.
DR PROSITE; PS50095; PLAT; 1.
DR PROSITE; PS51111; REJ; 1.
PE 3: Inferred from homology;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:EMP37219.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..2654
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004080038"
FT TRANSMEM 1549..1570
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1758..1777
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1789..1816
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1970..1996
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2008..2030
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2105..2127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2364..2381
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2401..2419
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2439..2464
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2485..2512
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 2547..2572
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 585..1285
FT /note="REJ"
FT /evidence="ECO:0000259|PROSITE:PS51111"
FT DOMAIN 1595..1712
FT /note="PLAT"
FT /evidence="ECO:0000259|PROSITE:PS50095"
FT REGION 1823..1842
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1919..1939
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 2204..2221
FT /evidence="ECO:0000256|PIRSR:PIRSR603915-2"
SQ SEQUENCE 2654 AA; 301405 MW; 5129B56BB290D3AB CRC64;
MPPLLLPSLL LQLLGHCGPP CLAAAAPPSF QLPPLLVTCS DPHGRVYGRQ DNEVWASCLW
DGPIELRYTR APGAVPRVQE GETQLPPPPR CRWYRDSAWV QDTSRWSGRA VLGPGLAGGG
PAPPWASSHI TVQCVSASCA VPTCLHRNLS IQVSGQDVRL FLLWPPEPPI LEWQPVQLGW
CARLKSSRWH YRFSSRGGSP AALLIPSNQH HKLLPPAAYP RAELHQVCAS YYSYRLTVHY
TRRGLYIASV SMEQGPRISL SLTLRVEPAL LHVLSAHSKL FSLPYQPLSL SWSLQSLGPR
TLAYRLLDMQ GTEGWSASYN PYALQSNFCA DSMSRKASET VLASIYFHVD GEWFGDLAGE
LSFSNATLGL TVNSETPTYL TLNAQKTKTG TYIFSRNHGL YYTTQANNAS APDDGFNTHY
IFFQQQSLSF LLTIEFVRLQ WYKFNMHLYL NRKGALFKSL MDRDIEVHIF NSGPSFLRSL
IYIVWFIPVQ HPMLQCEWTF NLQLFGSRKE YLIQNNTYIY DDHVRNAAHF VRRSVLPFNP
ALYTGFVAKV NCTRSGLTPA VLKVTVNTYA SKVMESLVSC QKKPCFIERL RIQKPDLVFP
IIRTKKGLQL ILYAKLQVNC TDLVRTEQIW KIYAVQDVMT IPDWTKPLNP PLIWRRQMLI
LQIPSFSLDY GLYLFNFSVK IIASEGVVEG SDTVFVQIEK SDLVAVIAGG TFRTVGFSDH
WTLDGSTSYD PDSLDRLEGL TYSWYCTKHV SDYATMTVST NGTCHPDQVD LKWIKFSSPT
QTVLPETLQG NTMYHFRLVI QKDNRKSYAD QTISVRPGSP PVLNVICIEN CGKFVIPTDR
FTLSGKCLNC RMTSRPVYHW SLFSGSFTEV NFDWASKTST GKSSAYMSIH ALTFMNIADQ
SYTLLLKITT WGGRSSTYRY SFYVNSPPRI GKCTVNPTRG VAFLTKFIVQ CSGFSDTNLP
LMYKVIAASD LLKSSRITSL EENTLGTIVY FDYQPKTPPS FLPIGIPSKK YTLTIYVQVY
DSLGAFSQVT LHTRVQDPAK SRPPDIMLNE LLALTSGSSA PMTSLLQIGD YLNVGYLVYM
VASILNDIKT APTIQVSKVE FRESLLNQSL SIPTANVMEV NQVVACISEL TQEVTEVNRA
SQQLAVRKLK EVSEALKRFR DKNLGSEQTE LLSTGILTGL SNVLKASLLD LRNVNVHAVK
QTFSVMETLS EVVLQGKVPG ENETVMEAKS WNIKLKKDEK WDVTNTFSTK KDCRNCFYPT
LKQGDHSELP IDAVISTVFY EFEENPFPWL AYRSDIVTTV TGFKMTGTKV NGDIIGIMPA
VAEVIIARKD KEYAAFKLTI GPDKTLPKTT GGFSFEVDRN SKDVFIQILT KLKVSFKVFI
YLGVNVTHTS PIASFFASHS EPAVASGNKS NNIDCAIKAP YVICLPQSLL RATAPVSGTD
KWNISIILQS QSIVRSRNNR LVSISLFNAA CLDLDGVQSQ WKEGTCVLGP LTSWQQVHCI
CKAKQHTKRT ASRTSSSKFN IKFLASKVFV IPNPVDLEKS LLAKIHKNAV TLLTVLFIFL
VYFLLALWAM RKDRTDKVSR DKVIVLPDND PFDKVCYLVT LYTGSRLGAG TTADVFLQLI
SQNGTSDVHH LRNPTYPSFI RGGTDTFLLT TKNDLGDIYS LRVWHNNGGS SPDWFLSRVK
VENMYTKEFW LFICRKWLAL DKDDRLLERT FVVTHPRVPL AKMDYFFINI ANELMDSHIW
LSVFAQVVTG SFNRLQRLSC CLAVLLCTLL INIMFFNADK NKEVVSIHLR YLISIIIGIE
SALVTIPVQM IITALFKYSQ KEPSPRDAAP NHPKESSPFM SGNLRNWKER LQKWYLAEAS
TQPVSSNSRE NSSNAHDSYS LQYFGKKRKQ RTPKMWSNCT ISEGAANAIA AEEENAADTS
TAKVTAQQTQ PPNSNFSNNY AEEKDASIQK ERKPLNIPLM LFRKRPQITF CWWCVYVSWI
LVIAVAGVSS FFIVLYGLSY GYKTSLEWLL ASIASFFESV LLLQTLKIIV FSALSTVYPK
YCENIPWTTR DNFLEIRLDE VTMDADEMRE RHYEIIRLRG TKQYQPLEED EITIMRKREK
IKSKAFIFLK DIVSHFVFLT LVLNIAYSTE NTNSFYYNQV IHKRFSLKLS NVDKLEHIYL
WVKSVFLPLI HNNHQPTFLS DSWSKILGLP RMRQVRAKST EKKCFYPHSF VNKFVISKSH
CLHKYGSDPE ERGDYVGSWT KGANRSITSD TSSYVGFTYQ SNRNHWVYYS YGELYTYGPG
GYTFYFFPAE QRPNSTKRLD VLQNSNWLDE ETWAVIIELT TFNPDVHLFC SIAVIFEVSH
FGLINTSLSV HSFTLPIFQQ QSRTQIFVFV TVLAFLLIYI MDEIHIIRQE RTKYIKNVSN
LINFGLKSVF FFFVFLQVIK FKIGADIVKF YLLNPNDFIP FHTVSHVDQT LRITMGFLAF
LIVLKTLRYS RFFYDVRLAQ RSILAALPGI CSMALVVAVY FFVYMAFGYL VFGQHEWNYN
NMIHSAQTVF SYCVSAFKDT AFTSNRLLGG LFLASFMLVM ICVLINLFQA VIMSAYEDMK
QPVYEEPSDE AEVITFLVHK IRRVWYFITC RTPSASDPDL LNSVLYGQAE RYSHRHLGLK
TKKINGKKMV YLVI
//
