ID M7BU94_CHEMY Unreviewed; 1288 AA.
AC M7BU94;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Pleckstrin like proteiny domain-containing family M member 1 {ECO:0000313|EMBL:EMP41406.1};
GN ORFNames=UY3_01324 {ECO:0000313|EMBL:EMP41406.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41406.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB491960; EMP41406.1; -; Genomic_DNA.
DR STRING; 8469.M7BU94; -.
DR eggNOG; KOG1829; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd13321; PH_PLEKHM1; 1.
DR CDD; cd17679; RUN_PLEKHM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR029423; LRRC37AB_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR042827; PLEKHM1_PH.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047326; RUN_PLEKHM1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1; 1.
DR Pfam; PF14914; LRRC37AB_C; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT TRANSMEM 188..210
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 307..449
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 761..852
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 159..179
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 485..512
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 652..707
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 726..745
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..509
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 657..683
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 692..706
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1288 AA; 143948 MW; 7480F3B695995B9F CRC64;
MNSKQGVINR LSHRKSAALT DAVLEKPSEN KDSSLDDILP SIHQVNETHW KHQKESSGFP
YALSGSSSPD NYSVQGDLFE AELNNRLHSL IPNQAVRNLI SHVIRTLKMD CTEPRVQLAC
AKLISKTGLL MKLFSEREDI KETSSLWRTY LWENGNVPNK SAHQRKASKK DSEELSPEPP
QYSYGNKLLL AISVTVVIMI IIAVICLIEV PGVSETSSME KPLWLRDMYL PLDSIRKKSM
AQKLYDRDSS DEEEIFNRAD VRSVECVLNT VASIDSRSGA LWLIKKQLVS SIKGLQKQYV
TSDAVVTSDT DDANALCCAL EAVFVHGLKA KYIKTDTGGK VKKPCGRAPL PQPVFWGLLK
TITHRNIILE LEQLSFISTD VGRCRAWLRL ALNDGLMECY LKLLLQEKSR LPEYYQTSAL
LLDAEECEFL LSFLQGLTSL TFELSYKSAV LNEWTVTPLS LSGLCPVSEL LEYLTSSSSE
SQRKESLGLV SRSSGSDDIE VQPSTLALSK NEDKSKRTCS TLSLNTMSSS QLSSSLGSDG
LLQASCTRSP DRCEEPLSCD SDLGTANAED LDRSLQEASH LHLNVTAEST LCSAPLPDTD
NPQSIRAEDL AKASKIPDPP SQVTGIQLSQ PIITHNGAAD KDSSQQLYII NPEDKDGTSE
INGDKKSQED LSPKRRSWIS EDDFYRPSPE GSSKGLTDSY GSSLEGAREG QSAELISALG
LERPLLSSSK TGKPKPSPDQ EQKGFHVVHR RQIGLSNPFR GLLKLGNLER RGAMGLWKEF
FCELSPLEFR LFLDHEERIY SENYSLLRCE SQGLVHSDGR FELVFSGKKL CLRAPSRDEA
EDWLDRIHEA RCKCRPQQEE EWETLDCPED DLEGHTIGVL LGDSAALLQY SNGAGNACDW
TSSLAPELDA IKESVLYMDV DKAWAPFIFS LSLEALKCFK VKNNEKTLSN SYGIETIQDI
LPDTSLGGPA FFKVITSKAI LKLQAESADA AAAWRGLVRR VLTSYLETAE EALTLGGNLD
GNSQAILKNT VKENGFFLQY LVAIPMEKGL DSQSFICAGC SRQIGLSFVK PKLCAFSGLY
YCDSCHQDDE SVIPSRLIHN WDLTKRAVSR QALKFLNQIR IQPLINLKLV NESLYAHVER
MSRICKSREQ LKLLGDYLIM CRSGALKELS KRLGYRDYLL ESPHKYSVAD LRQIADGIFE
VYLQSLIQFA SHHVYNCDLC TQRGFICQMC NHSSIIFPFE FDTTTRCRDC KTVFHRCCQD
SMKSCPRCER RQKYQQQLQA DVLMEPNM
//
