ID M7BVX6_CHEMY Unreviewed; 500 AA.
AC M7BVX6;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 53.
DE SubName: Full=Growth/differentiation factor 5 {ECO:0000313|EMBL:EMP41334.1};
DE Flags: Fragment;
GN ORFNames=UY3_01436 {ECO:0000313|EMBL:EMP41334.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41334.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the TGF-beta family.
CC {ECO:0000256|ARBA:ARBA00006656, ECO:0000256|RuleBase:RU000354}.
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DR EMBL; KB494182; EMP41334.1; -; Genomic_DNA.
DR RefSeq; XP_007053984.1; XM_007053922.1.
DR AlphaFoldDB; M7BVX6; -.
DR SMR; M7BVX6; -.
DR STRING; 8469.M7BVX6; -.
DR GeneID; 102946381; -.
DR KEGG; cmy:102946381; -.
DR CTD; 8200; -.
DR eggNOG; KOG3900; Eukaryota.
DR OrthoDB; 2912454at2759; -.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR CDD; cd19399; TGF_beta_GDF5; 1.
DR Gene3D; 2.60.120.970; -; 1.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR001839; TGF-b_C.
DR InterPro; IPR001111; TGF-b_propeptide.
DR InterPro; IPR015615; TGF-beta-rel.
DR InterPro; IPR017948; TGFb_CS.
DR PANTHER; PTHR11848:SF44; GROWTH/DIFFERENTIATION FACTOR 5; 1.
DR PANTHER; PTHR11848; TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR Pfam; PF00688; TGFb_propeptide; 1.
DR PRINTS; PR00669; INHIBINA.
DR SMART; SM00204; TGFB; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS00250; TGF_BETA_1; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW Secreted {ECO:0000256|ARBA:ARBA00022525}; Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..31
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 32..500
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5004080423"
FT DOMAIN 377..500
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 30..64
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 84..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 101..144
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 145..167
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 1
FT /evidence="ECO:0000313|EMBL:EMP41334.1"
SQ SEQUENCE 500 AA; 56309 MW; 4B21DE5E4E09ADFF CRC64;
MKILHFLTLL LWHLTWFYLV LVSVVLSNSE AGQSNPGSKL GLLKAEGKET NPSPRAGTFR
TGNHGYSTGT LKARAKSNTV QAGALLAKNN ESKKSLSREG TTDTKVGQSP NRQSGVRTVT
PKVQNLGSKA SLRKTGTGNT DASSYKTKKT KEPVTQREPK ETFKHPPITP HEYMLSLYRT
LSDAERKGIN GSVKLETGLA NTITSFIDKG QDDRAPAIRK QKYIFDISAL EKDGLLGAEL
RILRKKPSET WKPHSLGKTS QVKLFSCPTN RQAATLLDSR TVSTADTPKW EVFDIWKLFR
NFKNSVNLCF ELEAFDRGRA IDLRSMGLNR TGRQVNEKAL FLVFGRTKKR DLFFNEIKAR
SGQDDKTVYE YLFNQRRKRR APLATRQGKR PNKNLKARCS KKALHVNFKD MGWDDWIIAP
LEYEAYHCEG LCEFPLRSHL EPTNHAVIQT LMNSMDPEST PPTCCVPTRL SPISILFIDS
ANNVVYKQYE DMVVESCGCR
//