ID M7BX10_CHEMY Unreviewed; 932 AA.
AC M7BX10;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 50.
DE SubName: Full=Ras GTPase-activating protein 2 {ECO:0000313|EMBL:EMP40335.1};
GN ORFNames=UY3_02498 {ECO:0000313|EMBL:EMP40335.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP40335.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB514175; EMP40335.1; -; Genomic_DNA.
DR AlphaFoldDB; M7BX10; -.
DR STRING; 8469.M7BX10; -.
DR eggNOG; KOG2059; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR CDD; cd08401; C2A_RasA2_RasA3; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF21; RAS GTPASE-ACTIVATING PROTEIN 2; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00616; RasGAP; 2.
DR SMART; SM00239; C2; 2.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF52047; RNI-like; 1.
DR PROSITE; PS50004; C2; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 45..165
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 332..531
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 654..673
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 932 AA; 105921 MW; 6553600462B1B49F CRC64;
MAAEDGDGEG VRVLQNLRGK IYFKDAIKLL GHREPHRTVE VCPQHGYKCV IALCPGNGGH
CVMQASQKSE DGEAKNLVPY SGPNKMRDCF CTINLDQEEV FRTQVVEKSL SPFFGEEFYF
EIPRTFQCLS FYIYDKSVLQ RVLRIGKVAI KKEDLCKYTS KETWFLLQPV DSNSEVQGKV
HLELKLNELI TDNGSVCQQL VVNIKECHGL PLVNGQNCDP YATVSLVGPS RIDLWNNGNL
VQDVFLGEIK VPVKVLGNDS FQAWYLLQPR ENGNKSSKTD DLGSLRLNVC YTEDYVLPSE
YYVSLRNLLL KSPDVQPVSA SAAYILGEVC RDKYDAVLPL VRLLLHHHKI VQFVTAVAEL
DLKDTQEVNT IFRGNTLATR CLDEMMKIVG KHYLKVTLKP VLDEICESPK PCEIDPIKLK
EGDNVEVHKE NLRYYVDKVF NTIVQSSISC PTLMCDVFYS LRHLAAKRFP NDPHVQYSAV
SSFVFLRFFA VAVVSPHTFH LRPHYPFLDE VSSTESKEPS GMSEPLHLKE GEMYKRAQGR
TRIGKKNFKK RWFCLTSREL TYHKQREVFW RVGPADIQIE IDGDRETERI YSLFAINMPK
LQKMEEACGS IAVYQGPQKE LDDYSNFTIE DSVATFQTLQ QIIAIVEKLN EPHEKYRKKR
SSSAKYGSEH HTTASMEPAQ ITLAIRSTLN TTRIIQQYMQ NQNLAKRNWA SRRCQRGDES
DEDMDTDFSQ STGRDNVVIM VLMGQVHAVE CQFWAWETST DWWDRIVLQV WDDSQWLRNF
RMPGATAWQA MLLERNGCTN YPFCTLEITH VPIDAWSMER LGAAFPYSNL NSIVLDYTKF
GDKGINGLVS GLEGNRKLLT LSLCYCSLEP ESGSKLGPIV AQTAICLIKH SEHLIELDLD
GNAIGELCAT DILEALTERK KGGVSPTSVH KL
//
