ID M7BY00_CHEMY Unreviewed; 1784 AA.
AC M7BY00;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Trinucleotide repeat-containing gene 6A protein {ECO:0000313|EMBL:EMP36928.1};
GN ORFNames=UY3_05908 {ECO:0000313|EMBL:EMP36928.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP36928.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- SIMILARITY: Belongs to the GW182 family.
CC {ECO:0000256|ARBA:ARBA00007302}.
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DR EMBL; KB523472; EMP36928.1; -; Genomic_DNA.
DR STRING; 8469.M7BY00; -.
DR eggNOG; ENOG502QPQQ; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProt.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR CDD; cd12711; RRM_TNRC6A; 1.
DR Gene3D; 3.30.70.330; -; 1.
DR InterPro; IPR019486; Argonaute_hook_dom.
DR InterPro; IPR012677; Nucleotide-bd_a/b_plait_sf.
DR InterPro; IPR035979; RBD_domain_sf.
DR InterPro; IPR032226; TNRC6_PABC-bd.
DR InterPro; IPR034924; TNRC6A_RRM.
DR PANTHER; PTHR13020; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6; 1.
DR PANTHER; PTHR13020:SF28; TRINUCLEOTIDE REPEAT-CONTAINING GENE 6A PROTEIN; 1.
DR Pfam; PF10427; Ago_hook; 1.
DR Pfam; PF16608; TNRC6-PABC_bdg; 1.
DR SUPFAM; SSF54928; RNA-binding domain, RBD; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW RNA-binding {ECO:0000256|ARBA:ARBA00022884};
KW Translation regulation {ECO:0000256|ARBA:ARBA00022845}.
FT DOMAIN 992..1095
FT /note="Argonaute hook"
FT /evidence="ECO:0000259|Pfam:PF10427"
FT DOMAIN 1401..1592
FT /note="TNRC6 PABC binding"
FT /evidence="ECO:0000259|Pfam:PF16608"
FT REGION 1..73
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..186
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 500..622
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 643..732
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 746..1113
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1135..1159
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1226..1252
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1307..1336
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1473..1531
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..22
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..51
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 85..151
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 500..601
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 602..622
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 643..662
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 676..710
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 717..732
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..892
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 907..929
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 936..1006
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1022..1040
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1071..1085
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1248
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1784 AA; 190487 MW; F280D0DA3A59F170 CRC64;
MEERKKRKED KKKKEAAQKK AIEQKIKATS TNNNAKRATA NNQQQQQTLP RYPPREVPPR
FRHQEQKQLL KRGQQLPVIA ANLGSTPKVL NSQSGGSAVT SKQPVTNGEV PNSSSKKQSD
LNHSGLGSHY ENSHWGPVSS NSDSSTNWDK VIVDGSDKEA WPSITGSDPE LASECMDTDS
ASSSGSERNL VIMASGSTGG ENDSVRNGIG HGSQNKFVVG SNSNNVGNGS INGPWGISHG
TIISTCQVSV DAPDSKSESS NNRMNAWGTI NSSSNGGLNP STLNSNGNHG AWPVLENNGH
ALKGSVGSGN SGTNIQCSTI GQKSNNQSIN SKVGGSAHGS WASLQENCDS EVNGTRKVSF
SGQPQNLNTE MNGPNNTTNF MTSSLPNSAG SVQINELPNN TGPGAWRVST MNHSPIQASP
VTNGTSTSHL SNGEAKNGGS YGTTWVAYGS NYSGDKCSGP NSQANSDTVN ATLTQPGING
PGSTNFPING NKGGGVWEGG TVNSQNMPWG SANGVSSGGS RRGWGNAAQN TGTSISNGEW
NKLPSNQHSN ESVNGNSRKF TNGWKSAEED DLNSQNSAAS QITEQNNVWA KTGTGDSEGS
TESTGCHDDK VTAEGQNRER RKVDQHALLQ SIVSRTDLDP RVLSNTGWGQ TPIKQNTAWD
TETSPRGERK TDNGTEAWGG SVTQTSSSGG CVERPSPNVN DTSSISGWGD PKSATRWGDS
KGSNSQGGWE EDSAATVMVK SNQIWVSGKE DKSSWNDAQK IKQGWVDGQK ASQGWAVSAN
DSWGENSRSN HWGEAKKSSS GGSDSDRSVS GWNESAKSNS VTWGSSNTNP NNASGWDEPA
KSNPSQGWGE PPRSNQPQGW GDSSKPVNSP DWNKQQDVGS WGAPSTTNKP PGSGWLGGPI
PSPAKEEEPT GWEEPSPESI RRKMEIDDGT SAWGDPSKYN YKNVNMWNKN VPNSSSSSDQ
QAQVHQQLLP SSAMSNKESS NGSGWGEPST PATTVDNGTS AWGKPMDTGT SWGEPISDAA
VTSGWGNASV GQQASSKPGP KSMQDGWCGD DMSLPGSRQT SWEEEDDVEI GMWNSSSSQE
VNPSLNWPPY MKKMPTKRES PEETIPSNKM DMSGGILQDK RIELDKHGLN IGDYNRVVGK
GPGSRPQISK ESSMDRSPYF DKDGIVADES QNMQFISNQN MKLPPSNSAL PNQALGSLAG
LGMQNLNSVR QNGNPSVFGV GNIATQPRSM QQPPAQPLNS SQPNSRAQVP PPLLSPQVPV
SLLKYAPNNG GLSPLFGPQQ VAMLNQLSQL NQLSQISQLQ RLLAQQQKAQ NQRSMPSSGR
QQQEQQNIVN NEQFTNVDKG RSLSMQQQMM QQSRQLDPNL LMKQQTPPSQ QQPLHQPAMK
SFLENVIPHA TPELQKGPSP INAFSSFPIG MNSNLNVNMD MSSIKEPQSR LRKWTTVDSI
SVNTSLDQNS SKHGAISSGF RLEDSPFVPY DFLNSSNSPA SPPGSVGDGW PRAKSPNGSS
SVNWPPEFRP GEPWKGYPNI DPETDPYVTP GSVINNLSIN TVREVDHLRD RNSGSSSSLN
TALPSTSAWS SIRASSYNVS LSSTAQSTSG SSWGESSSGR ITNWLVLKNL TPQIDGSTLR
TLCMQHGPLI TFHLNLPHGN ALVRYSSKEE VVKAQKSLHM CVLGNTTILA EFASEEEISR
FFAQGQSLTP SPGWQSFGSS QNRLGSIDGS HSFSNRNDLN HWNGAGLSGT SSGDLHGTSL
WGSPNYSTSL WGTPSSSDTR GISSPSPINA FLSVDHLGGG GESM
//
