ID M7C0I9_CHEMY Unreviewed; 987 AA.
AC M7C0I9;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=dipeptidyl-peptidase IV {ECO:0000256|ARBA:ARBA00012062};
DE EC=3.4.14.5 {ECO:0000256|ARBA:ARBA00012062};
GN ORFNames=UY3_01055 {ECO:0000313|EMBL:EMP41660.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP41660.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Release of an N-terminal dipeptide, Xaa-Yaa-|-Zaa-, from a
CC polypeptide, preferentially when Yaa is Pro, provided Zaa is neither
CC Pro nor hydroxyproline.; EC=3.4.14.5;
CC Evidence={ECO:0000256|ARBA:ARBA00001257};
CC -!- SIMILARITY: Belongs to the peptidase S9B family. DPPIV subfamily.
CC {ECO:0000256|ARBA:ARBA00010036}.
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DR EMBL; KB486406; EMP41660.1; -; Genomic_DNA.
DR AlphaFoldDB; M7C0I9; -.
DR STRING; 8469.M7C0I9; -.
DR eggNOG; KOG2281; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 2.140.10.30; Dipeptidylpeptidase IV, N-terminal domain; 2.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR045785; Dpp_8/9_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR002469; Peptidase_S9B_N.
DR PANTHER; PTHR11731:SF98; DIPEPTIDYL PEPTIDASE 8; 1.
DR PANTHER; PTHR11731; PROTEASE FAMILY S9B,C DIPEPTIDYL-PEPTIDASE IV-RELATED; 1.
DR Pfam; PF19520; Dpp_8_9_N; 1.
DR Pfam; PF00930; DPPIV_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 1..146
FT /note="Dipeptidyl peptidase 8 /9 ,N-terminal"
FT /evidence="ECO:0000259|Pfam:PF19520"
FT DOMAIN 159..434
FT /note="Dipeptidylpeptidase IV N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00930"
FT DOMAIN 591..762
FT /note="Peptidase S9 prolyl oligopeptidase catalytic"
FT /evidence="ECO:0000259|Pfam:PF00326"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 987 AA; 111826 MW; 78865EBB8C01BF8E CRC64;
MAAAMETEQL GLEIFGTSES EEHAEAEEQP TLEPFYVERY SWSQLKKLLT DTRKYHGYMV
AKAPHDFTFV KKNDPEGPHS DRIYYLAMSG ENRENTLFYS EIPKTINKAE VLMLSWKPLL
DLFQASLDYG MYSREEELLR ERKRIGTVGI ASYDYHRESG TFLFQAGSGI YHVKDGGPHG
FTQQPLKPNL VETSCPNIRM DPKLCPADPN WIAFIHSNDI WISNILTREE RRLTFVHNEL
ANLEEDPRSA GVATFVLQEE FDRYTGYWWC PNAEPTVTGG KILRILYEEN DESEVEIIHV
TSPMLETRRT DSFRYPKTGT ANPKVTFKMS EITVDAEGRI AAVMDKELVQ PFEILFEGIE
YIARAGWTPE GKYAWSILLD RSQTRLQIVL ISPALFIAVE DDAMERQKLI DAVPDSVTPL
TIYEETTDIW INIHVDEAKK LVYFEGTKDS PLEHHLYVVS YKNPGEVKRL TDRSYSHACS
ISQDCDMFIS KFSNQKNPHC VSLYRLTGSE DDVAHRKKEF WATILDSAGP LPDYVPPEIF
SFESSSGFTL YGMMYKPHHL QPGKKYPTVL FIYGGPQVQL VNNRFKGIKY FRLNTLASLG
YVVVVIDNRG SCHRGLKFEG AFKYKMGQIE IDDQVEGLQY LASQYDFIDL DRVGIHGWSY
GGYLSLMALM QRSDLFRVAI AGAPVTLWIF YDTGYTERYM GHPDHNEQGY YLGSVAMQAE
KFPSEPHRLL LLHGFLDENV HFAHTSILLS FLVRAGKPYD LQPQMACISP LSTNSSDPLS
DWCDNWSVTD RQHEQQLKLM PYRQMARSQA QCGIWPQDIS FYPGLANVHD LLCKTDTANS
FVTNPCPSRS FLAVSVLHIV AARSLNTSMT TELGSPCSKN TPTTSARAVA LLPALAPERS
RQRYQFDTND VHDVTPDLQS STLSKALFAL DSGTCGFRDL PGLILTVNAS SPSRWTLTAV
TVFAASNDQS THQPARLAKD TATEMIL
//
