ID M7C1C2_CHEMY Unreviewed; 3286 AA.
AC M7C1C2;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 52.
DE SubName: Full=TPR and ankyrin repeat-containing protein 1 {ECO:0000313|EMBL:EMP38178.1};
GN ORFNames=UY3_04610 {ECO:0000313|EMBL:EMP38178.1};
OS Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Testudinata; Testudines; Cryptodira; Durocryptodira;
OC Americhelydia; Chelonioidea; Cheloniidae; Chelonia.
OX NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP38178.1, ECO:0000313|Proteomes:UP000031443};
RN [1] {ECO:0000313|Proteomes:UP000031443}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=23624526; DOI=10.1038/ng.2615;
RA Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z., Li C.,
RA White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y., Zheng Y.,
RA Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M., Li Q., Wang J.,
RA Zhang H., Yu L., Shigenobu S., Wang J., Liu J., Flicek P., Searle S.,
RA Wang J., Kuratani S., Yin Y., Aken B., Zhang G., Irie N.;
RT "The draft genomes of soft-shell turtle and green sea turtle yield insights
RT into the development and evolution of the turtle-specific body plan.";
RL Nat. Genet. 45:701-706(2013).
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DR EMBL; KB520471; EMP38178.1; -; Genomic_DNA.
DR STRING; 8469.M7C1C2; -.
DR eggNOG; ENOG502QQZC; Eukaryota.
DR Proteomes; UP000031443; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR039904; TRANK1.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR PANTHER; PTHR21529; MAMMARY TURMOR VIRUS RECEPTOR HOMOLOG 1, 2 MTVR1, 2; 1.
DR PANTHER; PTHR21529:SF4; TPR AND ANKYRIN REPEAT-CONTAINING PROTEIN 1; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR SUPFAM; SSF48452; TPR-like; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Coiled coil {ECO:0000256|SAM:Coils};
KW Helicase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Hydrolase {ECO:0000256|PROSITE-ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000031443}.
FT DOMAIN 977..1440
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 2993..3250
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 592..646
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 672..735
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1044..1085
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1215..1237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2716..2737
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2919..2949
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2269..2296
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 592..625
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 672..705
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1044..1066
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1067..1085
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2921..2949
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 998..1005
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
FT BINDING 3022
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 3286 AA; 376934 MW; C195B721DF8CE2C5 CRC64;
MDLMNYAEFM KKAGNENFKN GNYFMAIRNY DEAIRVLFQL FQWGMVSHRD VAVLLCNKSN
AFYSLGKWEE AYHCAKESLQ WDLSYVKGYY RSGYSLLRLS RTHDAVIMFS RGLTLLCGSV
DQSQIADFIV GIFTSVNDEK YIAPYFLPIF KNIVNERFDP LVWQAVIEKL AKKGMWQKYV
LFGQYERMER VPELVEWLIT IGANVGSIGA YPLHAIINLC IKASQTENVQ MLLNTGVDPT
IPDAQARCAA DILKKTKNFK AVDIINNHLA RHASSSKESP GKSKSKASVD ETNSFLDAFE
QFLMFCSPEN QAQHKNLLKH ETVQRFLKLL STVKEIPKEM VCDIYDTCAS SFIKLLLEKQ
MWHEVLLLLT RKANGEMPSC GGLIRNCSLS DLNIGSVIKQ VDRRDKRRVH LVRCLLERGA
SPEGTGAIPE KPLQICLKNN DFELAYLLLS RGADTRSVSI VEGDTPLHAA VSICLDKSDD
IGLRFLNYLL DLYGSNPSTF PHLNPNSQDK NGNTVMHIIF QKAQTKQVKK IMDLLAKFDI
NFNLKNKLGK DVRHRIKKND PRLLTWNTAV SEKRKYRQDT VGQLVKLPKS IPVCNTSQPK
STAHSSSASV WRASPGNSTP ANTEPVPDNW EEADGGQLTK QETGEVNKPL TLREGLVKAI
TDLIQHLQLG DNPIEDNSQV PNPSSALTSV EGKKSEPQQT CGYESLAHSK GDGADSEKVE
DTEKECDESD MPMPNGIGEE TVEVNGQVQD FDNMTWEIEC TSEMLKKLGS KAVPHYMKKK
IILAVQQLGN GEWTQGLQKR LKHLKADIQL YEAKLDKGAR MLWELAIDFS PRCSEAAEKI
IETEQSIHPL EKSGRVYTEI IRIWDIVLDH CKLDRAIGTI CTAYNRGLSC ILRKKLKGIS
KIKQSSNLKT QKRIPRCYVE DTEAEKTKEH IIPEYFPPAS AVETEYNIMK FHSFSTNMAL
NIINDMNSAV EYPFRVGELE YAVIDLSPKP MEPIILIGRS GTGKTTCCLY RLWKKFHSYW
EKAQQAGAPL LVRQVWQRRK FEIESEKSAG EEEDNEKQHN DDSSESIELE SIDDEQDDEG
EQCSSADDTE LNLLGDCEEE EEHSTEESDN LEHLHQIFVT KNHVLCQEVQ RNFIELSKSS
KSTSHFQPLE SNVYKLQDVK DENFPLYVTS KQLLLLLDAS MPDPFFLRNE DGSLKRTIVG
WSTQEDLVIP NWQEEEEESN AEVEYGEDEK AAEAHSREND PRVFVTYDVF ANEMWPKMMK
GKNSYNPALV WKEIKSFLKG SFEALSCPQG KLTEEEYKKL GRKRSPNFKE DRSEIYRLFC
IYQQIRSQRG YFDEEDVLYN LSQRLSKLED LPWSIHELYG DEIQDFTQAE LALLMKCIND
PNAMFLTGDT AQSIMKGVAF RFSDLRSLFH YASKNSVDKK QCGVRKPKRI YQLYQNYRSH
SGILHLASGV VDLLQHYFPE SFDRLPRDSG LFDGPKPTVL ESCSVSDLAI LLRGNKRKTQ
PIEFGAHQVI LVANEMVKDK IPEELSLALV LTIYEAKGLE FDDVLLYNFF TDSEAYKEWK
IISSFTPSSD SLGESKLVIE TPLEKNIATQ SRSPVLNPEM YKMLNGELKQ LYTAITRARV
NLWIFDENSD KRAPAFKYFI KREFVQVVKI DENKDLDDSM FVKTSTPEEW IAQGEYYAKH
QCWKVAAKCY QKGGAIEKEK LALAHDAVLN VQSKKSSPKE KQMDYMYLAK TYLECGEPKL
SLKCLIYAKE FQLCAALYEK LGKIKDAAYF YKRSQCYRDA SRCYEQIQEF DLALKMCCHE
ELYEEAAILV ERYEEILRTK RQPVSKLSYS ANQFYLEASA KYLRENKTKE MMAVLSRLDT
EDQLVFLKSR KCLAQAADLL RREGRQEEAA MLMKQHGFVL EAAKLTTKKE FRASCLLAAV
RFSVTGCSEL ENRDTILEEA LELCKQTNQK SSIAEATFLQ GVLKKDFRKL EEAFYKFLPL
NHCAGVVEAL FESTHCEPKS QGIFFLAPCG LEALLNLFRA LQKATTNAEK EMVKSCFDYF
GILPIDGNVC QVSQNEAGHI LQFLPDSPVL KEKKTKDHFI VGMEEVKSAL NKHFLSRLCS
ITCSILEQSY PDICMKFIAG LKCEDKTCKD FHRPLLRHEA KSILQCKMHL AAINGLLLQA
KRLFPKELLH EFNDIDEILT ADKYILCKSL LDFVFPKHFH LRVVSENPKA CKDILGLHQF
SKPCRMVLKE YIIFQFKSEN AINRRESTDL WLRAMQVFIL SSSYPEEFEK LLAKEEDDYN
KELKLLEAKK YEKEERGRGG RPKGVDGRYG MLIPDKYSGN AENTHLCFIR LLENSLERLY
VYRNPEDCKW MFFRFMNVLV KKCIEPLIPS IGNTVMLLEF QYILCCAVLM RLCKNITLCL
PKSYIALFHY WEFLFRKKDP KKEIRDMFSI IQEYKPKDPN EAVKEFKFHL LYVAKVLCGA
KNSNFNVLLD AFRDPDCITS GEAERTMVLC LVMLVNADQV LSPRCKSLLH EHFPEIKSKL
INMKKDCPSK VPERLVKIVE RVNDAVDMRK IAEGLQELLI ERDEEYLADC HWKWDTMYAK
GASVRGIFYE QVNLDRFESH LDPLEYFEEP ETELERDLYV EEREDPLTAI ASIKQQKQQQ
KAHAKRKLWR LFLLAYYCIK WRRNSCSKTD PIGMEMKELM SGIFKKADID RTQCDLCGVK
FIQGPENYFI QKEDLERETS EAVTPTETDP GEKESIERSE TVVASETYVK HRHLDEHRNK
YTAYQNYFEF FKRNVDPKLR EGLDVVDTIE QNTWITSHLI FKEHSNVVQR KIQENIKKIS
DIVEDIYKRK AWADAEEIMA KPVSSLSVNL GDARKWLKNT ESHMVKEEEV SSLVLAGSID
GGNREGYRKM GQISEAKGCS PLEASETIAI KAQDCQGDAG KPIKAKGEGK EVRKAKEEGA
GGEENVVHGE NELTRMKKMG EHKANKDEKK PQEFESTRLR RNVHTRADVE SCYEIGRTIG
DGNFAIVKQC RCCNTNENYA MKIVDKSKLK GKEDMMENEI LIIKSLSHPN IVSLIEVYET
EAEIYLILEY VPGGDLFDAI IESIKFTEHD AALMITDLCE ALVYIHGMNI VHRDLKPENL
LVQHNADKST TLKLADFGLA KKVTKPIFTV CGTPTYVAPE ILAEKGYGLE VDMWATGVIL
YILLCGFPPF RSQERDQEEL FQIIQLGHYE FLSPYWDSIS GAAKDLITRL LVIDPLKRYT
AQQVLQHPWI RTAGKTNSRN LQREVTINIE RHFRSQRRKG VVDDNT
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