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Database: UniProt
Entry: M7C2T2_CHEMY
LinkDB: M7C2T2_CHEMY
Original site: M7C2T2_CHEMY 
ID   M7C2T2_CHEMY            Unreviewed;      2001 AA.
AC   M7C2T2;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   10-MAY-2017, entry version 32.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   ORFNames=UY3_04032 {ECO:0000313|EMBL:EMP38713.1};
OS   Chelonia mydas (Green sea-turtle) (Chelonia agassizi).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Testudines; Cryptodira; Durocryptodira; Americhelydia;
OC   Chelonioidea; Cheloniidae; Chelonia.
OX   NCBI_TaxID=8469 {ECO:0000313|EMBL:EMP38713.1, ECO:0000313|Proteomes:UP000031443};
RN   [1] {ECO:0000313|Proteomes:UP000031443}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=23624526; DOI=10.1038/ng.2615;
RA   Wang Z., Pascual-Anaya J., Zadissa A., Li W., Niimura Y., Huang Z.,
RA   Li C., White S., Xiong Z., Fang D., Wang B., Ming Y., Chen Y.,
RA   Zheng Y., Kuraku S., Pignatelli M., Herrero J., Beal K., Nozawa M.,
RA   Li Q., Wang J., Zhang H., Yu L., Shigenobu S., Wang J., Liu J.,
RA   Flicek P., Searle S., Wang J., Kuratani S., Yin Y., Aken B., Zhang G.,
RA   Irie N.;
RT   "The draft genomes of soft-shell turtle and green sea turtle yield
RT   insights into the development and evolution of the turtle-specific
RT   body plan.";
RL   Nat. Genet. 45:701-706(2013).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; KB518693; EMP38713.1; -; Genomic_DNA.
DR   Proteomes; UP000031443; Unassembled WGS sequence.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000031443};
KW   Ion channel {ECO:0000256|RuleBase:RU361132,
KW   ECO:0000313|EMBL:EMP38713.1};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000031443};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM     92    110       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    155    174       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    186    207       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    213    233       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    363    390       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    727    745       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    757    780       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    837    865       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    924    950       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1289   1307       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1328   1350       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1356   1376       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1405   1431       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1490   1511       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1531   1549       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1561   1579       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1586   1611       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1648   1676       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1752   1775       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN       91    397       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      473    676       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   DOMAIN      727    955       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      964   1282       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN     1287   1518       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1530   1785       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1789   1844       GPHH. {ECO:0000259|Pfam:PF16905}.
FT   COILED      387    432       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2001 AA;  226725 MW;  B8BECB3BC7AF817C CRC64;
     MAQALLVPPG PDSFCYFTRE SLAAIEKRAT EEKAKKPKQD HTDDDDEDGP KPNSDLEAGK
     TLPFIYGDIP PGMASEPLED LDPYYINKKS TLFSMLIMCT ILTNCVFMTM SNPPEWTKNV
     EYTFTGIYTF ESLIKILARG FCLEGFTFLR DPWNWLDFSV ILMAYVTEFV NLGNVSALRT
     FRVLRALKTI SVIPGLKTIV GALIQSVKKL SDVMILTVFC LSVFALIGLQ LFMGNLRHKC
     LQWPPDNSTF EVNITSYLNS TMDVNGTFVN TTVSTFNWKE YIEDETHFYI LEGQRDALLC
     GNSSDAGQCP EGYICVKAGR NPNYGYTSFD TFSWAFLSLF RLMTQDFWEN LYQLTLRAAG
     KTYMIFFVLV IFLGSFYLVN LILAVVAMAY EEQNQATLEE AEQKEAEFQQ MLEQLKKQQE
     EAQATAAVAA ASVASRDLSG VGGLGELLES SSEASKLSSK SAKERRNRRK KRRQKELSEA
     EDKGDVEKFP KSESEDSIRR KSFRFSMEAS RLTYEKRFTS PHQSLLSIRG SLFSPRRNSR
     TSIFSFRGRA KDIGSENDFA DDEHSTLEDN ESRRESFFAP NRHGERRNSN ISEASRSSRM
     VTALPPNGKM HSTVDCNGVV SLVGGPSALT SPTGQLLPEG TTTETEIRKR RLSSYQISME
     MLEDSTARQR AMSIASILTN TMEELEESRQ KCPPCWYRFA NTFLIWDCWS PWLKVKHIVN
     LVVMDPFVDL AITICIVLNT LFMAMEHYPM TEQFSSVLTV GNLVFTGIFT AEMVLKIIAM
     DPYYYFQEGW NIFDGIIVSL SLMELGLANV EGLSVLRSFR LLRVFKLAKS WPTLNMLIKI
     IGNSVGALGN LTLVLAIIVF IFAVVGMQLF GKSYKDCVCK IATDCVLPRW HMHDFFHSFL
     IVFRVLCGEW IETMWDCMEV AGQAMCLIVF MLVMVIGNLV VLNLFLALLL SSFSSDNLAA
     TDDDNEMNNL QIAVARIQKG IDYVKKKLRE FVQKAFVRKQ KALEEIKAFE DLNNKKDSCI
     CNHTVVEISK DLNCLRDGNG TTSGVGTGSS VEKYVVDEND YMSFINNPGL TVTVPMAIGE
     SDFENLNTEE FSSESDIEES KETNTATPLI LDSQTKKTLY SGVMAQSTYY KLRYLTVSNL
     DRNSRRIHRF VRRIDTELRT DKACLFLSFR SKKPSEAKWC TSAKVNVFYG PEDGAGTGQR
     SKLELKTWMA RNLKLNASSS SEGSTVDIAP PGEGEQAEIE PEEALEPIAC FTKGCVQKFT
     CCQVSIEDGK GKIWWNLRKT CYSIVEHNWF ETFIVFMILL SSGALAFEDI YIEQRKTIKT
     MLEYADKVFT YIFILEMLLK WVAYGFQMYF TNAWCWLDFL IVDVSLVSLI ANALGYSELG
     AIKSLRTLRA LRPLRALSRF EGMRVVVNAL IGAIPSIMNV LLVCLIFWLI FSIMGVNLFA
     GKFYHCVNTT TGEMFDISDV DNYTQCEDLI KKNESARWKN VKVNFDNVGA GYLALLQVAT
     FKGWMDIMYA AVDSRDNKFQ GMVFDFVTKQ VFDISIMILI CLNMVTMMIE TDDQSDEMET
     ILHRINLVFI VLFTGECVLK LISLRYYYFT IGWNIFDFVV VILSIVGMFL AKVIEKYFVS
     PTLFRVIRLA RIGRILRLIK GAKGIRTLLF ALMMSLPALF NIGLLLFLVM FIYAIFGMSN
     FAYVKREVGI DDMFNFETFG NSMICLFQIT TSAGWDGLLA PILNSGEPDC DPYKDHPGSS
     VKGDCGNPSV GIFFFVSYII ISFLVVVNMY IAVILENFSV ATEESAEPLS EDDFEMFYEV
     WEKFDPDATQ FIEYSKLSDF AASLDPPLLI AKPNKVQLIA MDLPMVSGDR IHCLDILFAF
     TKRVLGESDE MDALRIQMED RFMAANPSKV SYEPITTTLK RKQEEVSATV IQRAYRCYIL
     KQKVKKVSCV YNKDKTKGDG LPVKDMITDK LNENSTPEKT YESSSTTSPP SYDSVTKPDK
     EKYEKDKVEK DYKSKNVRQS K
//
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