ID   M7MYS5_9BACT            Unreviewed;       804 AA.
AC   M7MYS5;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 37.
DE   SubName: Full=2-oxoisovalerate dehydrogenase subunit beta {ECO:0000313|EMBL:EMR01613.1};
DE            EC=1.2.4.4 {ECO:0000313|EMBL:EMR01613.1};
GN   Name=bfmBAB_2 {ECO:0000313|EMBL:EMR01613.1};
GN   ORFNames=ADICEAN_03266 {ECO:0000313|EMBL:EMR01613.1};
OS   Cesiribacter andamanensis AMV16.
OC   Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cesiribacteraceae;
OC   Cesiribacter.
OX   NCBI_TaxID=1279009 {ECO:0000313|EMBL:EMR01613.1, ECO:0000313|Proteomes:UP000011910};
RN   [1] {ECO:0000313|EMBL:EMR01613.1, ECO:0000313|Proteomes:UP000011910}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AMV16 {ECO:0000313|EMBL:EMR01613.1,
RC   ECO:0000313|Proteomes:UP000011910};
RX   PubMed=23682146;
RA   Shivaji S., Ara S., Begum Z., Srinivas T.N., Singh A., Kumar Pinnaka A.;
RT   "Draft Genome Sequence of Cesiribacter andamanensis Strain AMV16T, Isolated
RT   from a Soil Sample from a Mud Volcano in the Andaman Islands, India.";
RL   Genome Announc. 1:E00240-13(2013).
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMR01613.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AODQ01000102; EMR01613.1; -; Genomic_DNA.
DR   RefSeq; WP_009196649.1; NZ_AODQ01000102.1.
DR   AlphaFoldDB; M7MYS5; -.
DR   STRING; 1279009.ADICEAN_03266; -.
DR   PATRIC; fig|1279009.4.peg.3314; -.
DR   eggNOG; COG0022; Bacteria.
DR   eggNOG; COG1071; Bacteria.
DR   OrthoDB; 9769337at2; -.
DR   Proteomes; UP000011910; Unassembled WGS sequence.
DR   GO; GO:0003863; F:3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity; IEA:UniProtKB-EC.
DR   CDD; cd02000; TPP_E1_PDC_ADC_BCADC; 1.
DR   Gene3D; 3.40.50.920; -; 1.
DR   Gene3D; 3.40.50.970; -; 2.
DR   InterPro; IPR001017; DH_E1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR009014; Transketo_C/PFOR_II.
DR   InterPro; IPR005475; Transketolase-like_Pyr-bd.
DR   InterPro; IPR033248; Transketolase_C.
DR   PANTHER; PTHR42980:SF1; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA, MITOCHONDRIAL; 1.
DR   PANTHER; PTHR42980; 2-OXOISOVALERATE DEHYDROGENASE SUBUNIT BETA-RELATED; 1.
DR   Pfam; PF00676; E1_dh; 1.
DR   Pfam; PF02779; Transket_pyr; 1.
DR   Pfam; PF02780; Transketolase_C; 1.
DR   SMART; SM00861; Transket_pyr; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 2.
DR   SUPFAM; SSF52922; TK C-terminal domain-like; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000313|EMBL:EMR01613.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011910}.
FT   DOMAIN          470..644
FT                   /note="Transketolase-like pyrimidine-binding"
FT                   /evidence="ECO:0000259|SMART:SM00861"
SQ   SEQUENCE   804 AA;  89509 MW;  07461B430359BDD6 CRC64;
     MESLGTRTAA LETEGIALNP DEILQDYRLG WASRHASLLG RKEVFMGKAK FGIFGDGKEV
     AQLAMARAFQ PGDFRSGYYR DQTFMFAIGE LNMQQYFAQL YAHTDVEADP ASGGRLMNGH
     FATRMLDEQG EWKDLTASKN SSSDISPTAA QMPRLLGMAY ASKLFRQNPQ LHGLSKFSVQ
     GNEVAFGTIG NASTSEGMFY ETINAAGVLQ VPMLISVWDD GYGISVPQEY HTTKGSISEV
     LAGFQRTDEK AGVEIIRVKG WDYPALVEAY QRAAAICRNE HVPVLVHVEE LTQPQGHSTS
     GSHERYKSAE RLEWEAEHDC LRKMREWLLQ HELASESELE AIENEAAADA REAKKEAWEA
     FRASVKRDHQ QAEALLEEAA ARHEAIAPLL DELKKVLNPI RMDAIRTVKR ALWLLRAESS
     DAKQGLADWL KKVLAENEER FSSHLYSESP KAALQVQEVK ADIREEDPLV DGREVLQACF
     DAMLERDPRV FAFGEDVGRI GDVNQAFAGL QAKWGELRVT DTGIRECTII GQGIGAALRG
     LRPIAEIQYL DYLLYAIQIL SDDLASLQYR TKGGQKAPLI VRTRGHRLEG VWHSGSPIGM
     ILHSLRGMHV LVPRNMTQAA GFYNTLLASD EPGLIIEVLN GYRLKERIPR NLAEFTLPLG
     VPEILREGQD VTIITYGAMC RIVLEAAQHL DEMGISCEVI DVQSLLPFDV HHSIVESLKK
     TNRVVFADED VPGGASAYMM QQVLEEQGGY FYLDSQPLTI AAKAHRPAYS SDGDYFSKPS
     TETVVERVYG LMAEAEPQRF PALY
//