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Database: UniProt
Entry: M7NFZ4_9BACL
LinkDB: M7NFZ4_9BACL
Original site: M7NFZ4_9BACL 
ID   M7NFZ4_9BACL            Unreviewed;       733 AA.
AC   M7NFZ4;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 38.
DE   RecName: Full=Ribonucleoside-diphosphate reductase {ECO:0000256|ARBA:ARBA00012274, ECO:0000256|RuleBase:RU003410};
DE            EC=1.17.4.1 {ECO:0000256|ARBA:ARBA00012274, ECO:0000256|RuleBase:RU003410};
GN   Name=nrdE2 {ECO:0000313|EMBL:EMR06111.1};
GN   ORFNames=C772_01756 {ECO:0000313|EMBL:EMR06111.1};
OS   Bhargavaea cecembensis DSE10.
OC   Bacteria; Bacillota; Bacilli; Bacillales; Planococcaceae; Bhargavaea.
OX   NCBI_TaxID=1235279 {ECO:0000313|EMBL:EMR06111.1, ECO:0000313|Proteomes:UP000011919};
RN   [1] {ECO:0000313|EMBL:EMR06111.1, ECO:0000313|Proteomes:UP000011919}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSE10 {ECO:0000313|EMBL:EMR06111.1,
RC   ECO:0000313|Proteomes:UP000011919};
RX   PubMed=23766406;
RA   Shivaji S., Ara S., Begum Z., Ruth M., Singh A., Kumar Pinnaka A.;
RT   "Draft Genome Sequence of Bhargavaea cecembensis Strain DSE10T, Isolated
RT   from a Deep-Sea Sediment Sample Collected at a Depth of 5,904 m from the
RT   Chagos-Laccadive Ridge System in the Indian Ocean.";
RL   Genome Announc. 1:e00346-13(2013).
CC   -!- FUNCTION: Provides the precursors necessary for DNA synthesis.
CC       Catalyzes the biosynthesis of deoxyribonucleotides from the
CC       corresponding ribonucleotides. {ECO:0000256|RuleBase:RU003410}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=[thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-
CC         diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-
CC         diphosphate; Xref=Rhea:RHEA:23252, Rhea:RHEA-COMP:10698, Rhea:RHEA-
CC         COMP:10700, ChEBI:CHEBI:15377, ChEBI:CHEBI:29950, ChEBI:CHEBI:50058,
CC         ChEBI:CHEBI:57930, ChEBI:CHEBI:73316; EC=1.17.4.1;
CC         Evidence={ECO:0000256|ARBA:ARBA00000206,
CC         ECO:0000256|RuleBase:RU003410};
CC   -!- PATHWAY: Genetic information processing; DNA replication.
CC       {ECO:0000256|ARBA:ARBA00005160, ECO:0000256|RuleBase:RU003410}.
CC   -!- SIMILARITY: Belongs to the ribonucleoside diphosphate reductase large
CC       chain family. {ECO:0000256|ARBA:ARBA00010406,
CC       ECO:0000256|RuleBase:RU003410}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMR06111.1}.
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DR   EMBL; AOFT01000008; EMR06111.1; -; Genomic_DNA.
DR   RefSeq; WP_008299182.1; NZ_AOFT01000008.1.
DR   AlphaFoldDB; M7NFZ4; -.
DR   STRING; 1235279.C772_01756; -.
DR   PATRIC; fig|1235279.3.peg.1753; -.
DR   eggNOG; COG0209; Bacteria.
DR   OrthoDB; 9762933at2; -.
DR   UniPathway; UPA00326; -.
DR   Proteomes; UP000011919; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0004748; F:ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor; IEA:UniProtKB-EC.
DR   GO; GO:0009263; P:deoxyribonucleotide biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-UniPathway.
DR   CDD; cd01679; RNR_I; 1.
DR   Gene3D; 3.20.70.20; -; 1.
DR   InterPro; IPR013346; NrdE_NrdA_C.
DR   InterPro; IPR000788; RNR_lg_C.
DR   InterPro; IPR013509; RNR_lsu_N.
DR   InterPro; IPR008926; RNR_R1-su_N.
DR   InterPro; IPR039718; Rrm1.
DR   NCBIfam; TIGR02506; NrdE_NrdA; 1.
DR   PANTHER; PTHR11573; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE CHAIN; 1.
DR   PANTHER; PTHR11573:SF6; RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE LARGE SUBUNIT; 1.
DR   Pfam; PF02867; Ribonuc_red_lgC; 1.
DR   Pfam; PF00317; Ribonuc_red_lgN; 1.
DR   PRINTS; PR01183; RIBORDTASEM1.
DR   SUPFAM; SSF51998; PFL-like glycyl radical enzymes; 1.
DR   SUPFAM; SSF48168; R1 subunit of ribonucleotide reductase, N-terminal domain; 1.
DR   PROSITE; PS00089; RIBORED_LARGE; 1.
PE   3: Inferred from homology;
KW   Deoxyribonucleotide synthesis {ECO:0000256|ARBA:ARBA00023116,
KW   ECO:0000256|RuleBase:RU003410};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002,
KW   ECO:0000256|RuleBase:RU003410};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011919}.
FT   DOMAIN          590..612
FT                   /note="Ribonucleotide reductase large subunit"
FT                   /evidence="ECO:0000259|PROSITE:PS00089"
SQ   SEQUENCE   733 AA;  82993 MW;  F4C95ADA76371D33 CRC64;
     MVTTKPTDQL DILSALEQEF TSEKIAPLRR AAEGYSGPSL SQHLIREALG RVDESETYWT
     DVAARILLAQ LYRDQQERRE TEDAYGDFAR HVRTQAEAGL YTLALTEHYS ERELQEIGTF
     LDPSRDRLFT YTGLKTLTDR YVATDFNKKQ VELPQERWLV IAMTLMRNET EDRLGKIKEA
     YWALSNLYMT VATPTLANAG KPHGQLSSCF IDTVDDSLQG IYDSNTDIAN LSKYGGGIGV
     YMGKVRSRGA AIRGFKGASS GVLPWIKQLN NTAVSVDQLG QRQGAVAVYL DVWHKDILTF
     LDLKLNNGDE RLRAHDIFTG VCLPDLFMEQ VEARGDWHLF DPHEVRTVMG WSLEDFYDES
     FGAGSFRERY ADCVAHPDIH SEKVPAIDIM KRIMRSQLET GVPFMFYRDE VNRMNPNKHE
     GIIYSSNLCS EIAQNMSATS ASQEVLEDGV IVSRRTPGDF VVCNLSSINL GKAVPAGVLG
     RLIDIQVRML DNVIDLNQIP VLQAQVTNRR YRGIGLGTFG WHHLLALNSI QWESEEAVEF
     ADKLYEDIAY HTIRASAKLA GEKGAYPLFF GSDWQTGTYF GRRGYKGERW DALRVEVEKS
     GVRNGYMMAV APNSSTSVIA GSTASIDPVF RPFYHEEKKD YKLPVVAPDL DHRTYDVYRR
     SAYIVDQRWS VRQNAARQRH IDQSISFNLY VPNTIRASVL LDLHLQAWKS GLKTTYYTRS
     TASDVEECEW CQS
//
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