ID M7NM98_PNEMU Unreviewed; 1174 AA.
AC M7NM98;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 50.
DE RecName: Full=Structural maintenance of chromosomes protein {ECO:0000256|PIRNR:PIRNR005719};
GN ORFNames=PNEG_01962 {ECO:0000313|EMBL:EMR09778.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09778.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|PIRNR:PIRNR005719}.
CC -!- SIMILARITY: Belongs to the SMC family. SMC2 subfamily.
CC {ECO:0000256|ARBA:ARBA00005231}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR09778.1}.
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DR EMBL; AFWA02000009; EMR09778.1; -; Genomic_DNA.
DR RefSeq; XP_007873939.1; XM_007875748.1.
DR AlphaFoldDB; M7NM98; -.
DR STRING; 1069680.M7NM98; -.
DR GeneID; 19895656; -.
DR VEuPathDB; FungiDB:PNEG_01962; -.
DR eggNOG; KOG0933; Eukaryota.
DR HOGENOM; CLU_001042_9_0_1; -.
DR OMA; HNKIAME; -.
DR OrthoDB; 231904at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0030261; P:chromosome condensation; IEA:UniProtKB-KW.
DR CDD; cd03273; ABC_SMC2_euk; 1.
DR Gene3D; 1.20.1060.20; -; 1.
DR Gene3D; 3.30.70.1620; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR003395; RecF/RecN/SMC_N.
DR InterPro; IPR024704; SMC.
DR InterPro; IPR027120; Smc2_ABC.
DR InterPro; IPR010935; SMC_hinge.
DR InterPro; IPR036277; SMC_hinge_sf.
DR PANTHER; PTHR43977:SF2; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN; 1.
DR PANTHER; PTHR43977; STRUCTURAL MAINTENANCE OF CHROMOSOMES PROTEIN 3; 1.
DR Pfam; PF06470; SMC_hinge; 1.
DR Pfam; PF02463; SMC_N; 1.
DR PIRSF; PIRSF005719; SMC; 1.
DR SMART; SM00968; SMC_hinge; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF75553; Smc hinge domain; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00022776};
KW Cell division {ECO:0000256|ARBA:ARBA00022618};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW DNA condensation {ECO:0000256|ARBA:ARBA00023067};
KW Mitosis {ECO:0000256|ARBA:ARBA00022776};
KW Nucleus {ECO:0000256|PIRNR:PIRNR005719};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 521..642
FT /note="SMC hinge"
FT /evidence="ECO:0000259|SMART:SM00968"
FT COILED 246..294
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 319..503
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 747..939
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1174 AA; 134279 MW; FD700995CB5B19A6 CRC64;
MYLSEIIIDG FKSYAHRTVI SGLDTCFNAI TGPNGSGKSN ILDAICFVLG ITNMSTVRAQ
NLQDLIYKRG QAGITKASVT VIFDNSDSKK SPIGFEDHPQ ITVTRQIIMG GMSKYLINGH
RAQQQTVQNL FHSVQLNINN PNFLIMQGRI TKVLNMKSME ILSMIEEAAG TRMFEERKDK
AIRTITKKDR KVEEINALLA EEIEPKLEKL RQEKKAFLEY QQIQSDVERF TKLVVAYDYL
KSNDKLTEFE IDLQNKNNRV IDLESSIKTR KYEVTSIEEN IKTLKEEKEI QLRKGGNFQK
LENDFKDCSH ELVRLNTLIE LKEGSLAEEK IKLAKLEETS KELHISLEEK KRHFHSIEEF
YNKLKIEFDA KNDEMNRKEE LLQTLSTGIA AREGQTNNYT DQLQEARNNL NRAMTEEKQI
ILKMDHFQKR IIEIGPKANK AQKENEVLLN GLEKMKQELK VIEEKISALG LQNNINDNFY
KEKSDYETKI ASLTSRYENL KRNVANIDFT YSSPSPEFDH LKVLGFVAQL FTLDEKNYNA
SMALEVCAGG RLYNVVVEDE IVAAQLLQHG RLKKRVTIIP LSKISSVKIP VEKIDMAQKR
APGKVNLALD LINYGKNVKA AMEYVFGSTV ICENAEIAKQ ITFDPNLSLK SITLNGDIYD
PSGTLSGGSS TSSNGVLVQL QKLNEVKNEL NLYNNKLLEI NTFLEKNKER LDKISSLKKN
YDLKSHEIKL TEKQISLNSS SKVMNEIKEL ESNIELCKTT LAEVKLKQEQ YKKDIKEIEK
DMEEFKNNKD SKLLQLQKTL EKLKSVVEKQ SENVKLECKK YQSLKLEKEQ LEGDLVIIQK
QLKENNALIS SQNSEINTLK FEQAQAKENY EKLQRVLENE RAKLTGYDKE FKHLENAMKI
KTSYISEANL ELQSLRHEIN RLNKDKQSTL QSLNQMEAQY EWISDEKENF GKPSTAFDFS
DYDIKKCKAS LNSLTERFQA LKKKINPKVI NMIDGVEKKE NALKTMVKTI HKDKRKIEDT
IKSLEDYKME ALQRTWKKVN SDFGKIFSDL LPGSFAKLVP LDKKTIADGL EIKVCLGKVW
KDSLAELSGG QRSLVALSLI MSLLQFKPAP MYILDEVDAA LDLSHTQNIG HLIKTKFKGA
QFIVVSLKDG MFSNANRIFT TKFVHGHGSV VETM
//
