ID M7NRL7_PNEMU Unreviewed; 459 AA.
AC M7NRL7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:EMR11383.1};
GN ORFNames=PNEG_00408 {ECO:0000313|EMBL:EMR11383.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR11383.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- SIMILARITY: Belongs to the beclin family.
CC {ECO:0000256|ARBA:ARBA00005965}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR11383.1}.
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DR EMBL; AFWA02000001; EMR11383.1; -; Genomic_DNA.
DR RefSeq; XP_007872284.1; XM_007874093.1.
DR AlphaFoldDB; M7NRL7; -.
DR STRING; 1069680.M7NRL7; -.
DR GeneID; 19894106; -.
DR VEuPathDB; FungiDB:PNEG_00408; -.
DR eggNOG; KOG2751; Eukaryota.
DR HOGENOM; CLU_024219_3_0_1; -.
DR OMA; EWDVYKA; -.
DR OrthoDB; 11439at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0006914; P:autophagy; IEA:InterPro.
DR Gene3D; 6.10.250.3110; -; 1.
DR Gene3D; 1.10.418.40; Autophagy protein 6/Beclin 1; 1.
DR InterPro; IPR007243; Atg6/Beclin.
DR InterPro; IPR038274; Atg6/Beclin_C_sf.
DR InterPro; IPR041691; Atg6/beclin_CC.
DR InterPro; IPR040455; Atg6_BARA.
DR PANTHER; PTHR12768; BECLIN 1; 1.
DR PANTHER; PTHR12768:SF4; BECLIN-1; 1.
DR Pfam; PF04111; APG6; 1.
DR Pfam; PF17675; APG6_N; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 142..270
FT /note="Atg6/beclin coiled-coil"
FT /evidence="ECO:0000259|Pfam:PF17675"
FT DOMAIN 273..455
FT /note="Atg6 BARA"
FT /evidence="ECO:0000259|Pfam:PF04111"
FT COILED 207..234
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 459 AA; 54014 MW; F0471A08852B6B26 CRC64;
MTLSMSLICQ YCKSPLRFEN LKEINTATFN LLIGSLKEKK QEFYEEDMIP LLFPESRKIY
YHEAINTLIN SLTEDQITNK TSSRNISYIL FESEDLKSFD TSVSGMFNSN NQINDLETTF
HEPPTFEHLF HIISFLSDIR HPICSECCEK LLDTMSKHHH YLKNERDTYI GILNHINNVL
LHDDEIEKIK LEIEDNLKKE AVALKTIAQL KKKQQDIEKE VKKLDEESLI LDKEEEIFWK
ERNSFLLKLQ EFQNERDTLN LQYDYNIKQL EELKEANVYK DIFCISHNGQ FGTINDLKFG
RLPSYPANWD EINAAWGLIV LLLHSIAKKL NFKFSEYKLN PLGSTSTIDK LEFHNDSSYP
SKTISFELYN SDNLLIKRFF MQKKFDIAMI SFLQCLKQIG DYLKQIDPSF KFPYKIQKDK
IGNANISISF NSDEIWTRSL KYLLTNLKYI IAYTTHHLS
//
