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Database: UniProt
Entry: M7NRT7_PNEMU
LinkDB: M7NRT7_PNEMU
Original site: M7NRT7_PNEMU 
ID   M7NRT7_PNEMU            Unreviewed;        92 AA.
AC   M7NRT7;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 49.
DE   RecName: Full=Small nuclear ribonucleoprotein E {ECO:0000256|RuleBase:RU365053};
DE            Short=snRNP-E {ECO:0000256|RuleBase:RU365053};
DE   AltName: Full=Sm protein E {ECO:0000256|RuleBase:RU365053};
GN   ORFNames=PNEG_01987 {ECO:0000313|EMBL:EMR09806.1};
OS   Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS   (Pneumocystis carinii f. sp. muris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX   NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09806.1, ECO:0000313|Proteomes:UP000011958};
RN   [1] {ECO:0000313|Proteomes:UP000011958}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX   PubMed=26899007; DOI=10.1038/ncomms10740;
RA   Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA   Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA   Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA   Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA   Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA   Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA   Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT   "Genome analysis of three Pneumocystis species reveals adaptation
RT   mechanisms to life exclusively in mammalian hosts.";
RL   Nat. Commun. 7:10740-10740(2016).
CC   -!- FUNCTION: Involved in pre-mRNA splicing. Binds and is required for the
CC       stability of snRNA U1, U2, U4 and U5 which contain a highly conserved
CC       structural motif called the Sm binding site. Involved in cap
CC       modification. {ECO:0000256|RuleBase:RU365053}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC       ECO:0000256|RuleBase:RU365053}.
CC   -!- SIMILARITY: Belongs to the snRNP Sm proteins family.
CC       {ECO:0000256|ARBA:ARBA00006850, ECO:0000256|RuleBase:RU365053}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:EMR09806.1}.
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DR   EMBL; AFWA02000009; EMR09806.1; -; Genomic_DNA.
DR   RefSeq; XP_007873967.1; XM_007875776.1.
DR   AlphaFoldDB; M7NRT7; -.
DR   STRING; 1069680.M7NRT7; -.
DR   GeneID; 19895681; -.
DR   VEuPathDB; FungiDB:PNEG_01987; -.
DR   eggNOG; KOG1774; Eukaryota.
DR   HOGENOM; CLU_125186_1_0_1; -.
DR   OMA; VPPINCI; -.
DR   OrthoDB; 5113494at2759; -.
DR   Proteomes; UP000011958; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR   GO; GO:0005681; C:spliceosomal complex; IEA:UniProtKB-KW.
DR   GO; GO:0005685; C:U1 snRNP; IEA:UniProtKB-UniRule.
DR   GO; GO:0005686; C:U2 snRNP; IEA:UniProtKB-UniRule.
DR   GO; GO:0005687; C:U4 snRNP; IEA:UniProtKB-UniRule.
DR   GO; GO:0046540; C:U4/U6 x U5 tri-snRNP complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005682; C:U5 snRNP; IEA:UniProtKB-UniRule.
DR   GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0000387; P:spliceosomal snRNP assembly; IEA:UniProtKB-UniRule.
DR   CDD; cd01718; Sm_E; 1.
DR   Gene3D; 2.30.30.100; -; 1.
DR   InterPro; IPR010920; LSM_dom_sf.
DR   InterPro; IPR047575; Sm.
DR   InterPro; IPR001163; Sm_dom_euk/arc.
DR   InterPro; IPR027078; snRNP-E.
DR   PANTHER; PTHR11193; SMALL NUCLEAR RIBONUCLEOPROTEIN E; 1.
DR   PANTHER; PTHR11193:SF0; SMALL NUCLEAR RIBONUCLEOPROTEIN E; 1.
DR   Pfam; PF01423; LSM; 1.
DR   SMART; SM00651; Sm; 1.
DR   SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
DR   PROSITE; PS52002; SM; 1.
PE   3: Inferred from homology;
KW   mRNA processing {ECO:0000256|RuleBase:RU365053};
KW   mRNA splicing {ECO:0000256|RuleBase:RU365053};
KW   Nucleus {ECO:0000256|RuleBase:RU365053};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW   Ribonucleoprotein {ECO:0000256|ARBA:ARBA00023274,
KW   ECO:0000256|RuleBase:RU365053};
KW   RNA-binding {ECO:0000256|RuleBase:RU365053};
KW   Spliceosome {ECO:0000256|RuleBase:RU365053}.
FT   DOMAIN          18..92
FT                   /note="Sm"
FT                   /evidence="ECO:0000259|PROSITE:PS52002"
SQ   SEQUENCE   92 AA;  10710 MW;  F86EAAA51D97629A CRC64;
     MSVRTQSGRT QKVMIPPINF IFKLLQQHID VCIWLYEQID IRIEGKIRGF DEFMNLVIDE
     AIEVAQKKNS RRQLGRILLK GDNITLIQAA QL
//
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