ID M7NS15_PNEMU Unreviewed; 755 AA.
AC M7NS15;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE SubName: Full=Translation elongation factor G {ECO:0000313|EMBL:EMR10072.1};
GN ORFNames=PNEG_01823 {ECO:0000313|EMBL:EMR10072.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR10072.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR10072.1}.
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DR EMBL; AFWA02000008; EMR10072.1; -; Genomic_DNA.
DR RefSeq; XP_007873794.1; XM_007875603.1.
DR AlphaFoldDB; M7NS15; -.
DR STRING; 1069680.M7NS15; -.
DR GeneID; 19895517; -.
DR VEuPathDB; FungiDB:PNEG_01823; -.
DR eggNOG; KOG0465; Eukaryota.
DR HOGENOM; CLU_002794_4_1_1; -.
DR OMA; GPQFTFP; -.
DR OrthoDB; 148165at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR GO; GO:0003746; F:translation elongation factor activity; IEA:UniProtKB-KW.
DR CDD; cd03713; EFG_mtEFG_C; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.70.240; -; 1.
DR Gene3D; 3.30.70.870; Elongation Factor G (Translational Gtpase), domain 3; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR041095; EFG_II.
DR InterPro; IPR035647; EFG_III/V.
DR InterPro; IPR035649; EFG_V.
DR InterPro; IPR000640; EFG_V-like.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR43261:SF1; RIBOSOME-RELEASING FACTOR 2, MITOCHONDRIAL; 1.
DR PANTHER; PTHR43261; TRANSLATION ELONGATION FACTOR G-RELATED; 1.
DR Pfam; PF00679; EFG_C; 1.
DR Pfam; PF14492; EFG_III; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SMART; SM00838; EFG_C; 1.
DR SUPFAM; SSF54980; EF-G C-terminal domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 4: Predicted;
KW Elongation factor {ECO:0000313|EMBL:EMR10072.1};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Protein biosynthesis {ECO:0000313|EMBL:EMR10072.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 2..290
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 755 AA; 84467 MW; E00ABC839966BF9F CRC64;
MSKIRNIGIL AHVDAGKTTT IERMLFYSGY TDRLGEVDKG STVMDYLPME RERGITIKSA
AIWFMWNGYR INFIDTPGHA DFVFEVERAL SVMNGAVVLL DAISGIEAQT IHVWRRATRW
KLPRLIFINK MDRPDVDPTK IFTQFQHQFG VRLVAMQVPI FNNDSGVDSR FCGLIDIISM
EAFLWHPNSD GTVFTRQPLD AVTNKKQLKQ ATDARIHLVE TLTEVDEILI DAFLNSGSNL
LHIDSNVLSQ AVRRATLSNF LIPVFYGSSL KNIGIQLLLD AMVTYLPSSE ERSDETLSFI
KDISKNLHQT EGQSENTPIE YKNISLMSNP LVNSLKREDI SVFAIVFKVV VNRGIRYVYI
AMHKGCLQKG QWLRLVRGGR IRVEELRECI GGTTILGSDP TLPRPFSGVK ANNTGSPINR
IDQGNWGIMI SNDRIRTGDI FVDSADIDMR IDHITDMKIQ AIFDELPTPV VSVALEPIGA
ETIRSLPQVL SWLLDEDPSL RVDDKEGQIL LTGIGELHIA AACDRLINHF RLNIRIGNVQ
LQRREKILNE VVTQQTYHAT MHKQIPIDVV VRLKPIDNPE KLNGLDNEII INESVTNECK
YLGIQKVQHA CTAGVLAGLQ SGPIKQLPIS GAKVIVESVN TYGITITPSI LGAAVRFAIL
HLISNLPNHF VSIVEPIMYV IITLSHDKDL GNVIKDLTGL RQGKLISINN CSTGHHILIA
HIPLKYMLQY TSVLRELTSG TGSFIMSFNH FGTPY
//
