ID M7NSW7_PNEMU Unreviewed; 2737 AA.
AC M7NSW7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE RecName: Full=FMP27 GFWDK domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PNEG_01623 {ECO:0000313|EMBL:EMR10372.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR10372.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR10372.1}.
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DR EMBL; AFWA02000004; EMR10372.1; -; Genomic_DNA.
DR RefSeq; XP_007873581.1; XM_007875390.1.
DR STRING; 1069680.M7NSW7; -.
DR GeneID; 19895317; -.
DR VEuPathDB; FungiDB:PNEG_01623; -.
DR eggNOG; KOG1910; Eukaryota.
DR HOGENOM; CLU_000592_0_0_1; -.
DR OMA; FKKVIMK; -.
DR OrthoDB; 607689at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR InterPro; IPR019443; BLTP2/FMP27/Hobbit_C.
DR InterPro; IPR019441; FMP27/BLTP2/Hobbit_GFWDK_RBG.
DR InterPro; IPR019439; FMP27/BLTP2_N.
DR InterPro; IPR019409; FMP27_sixth_RBG.
DR InterPro; IPR019415; FMP27_SW_RBG.
DR InterPro; IPR019449; FMP27_WPPW_RBG.
DR InterPro; IPR045167; Hobbit.
DR PANTHER; PTHR15678; ANTIGEN MLAA-22-RELATED; 1.
DR PANTHER; PTHR15678:SF6; PROTEIN KIAA0100; 1.
DR Pfam; PF10293; DUF2405; 1.
DR Pfam; PF10351; FMP27-BLTP2_C; 1.
DR Pfam; PF10344; FMP27-BLTP2_N; 1.
DR Pfam; PF10347; Fmp27_GFWDK; 1.
DR Pfam; PF10305; Fmp27_SW; 1.
DR Pfam; PF10359; Fmp27_WPPW; 1.
DR SMART; SM01214; Fmp27_GFWDK; 1.
DR SMART; SM01215; Fmp27_SW; 1.
DR SMART; SM01216; Fmp27_WPPW; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 7..27
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1063..1165
FT /note="FMP27 SW motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01215"
FT DOMAIN 1183..1339
FT /note="FMP27/BLTP2/Hobbit GFWDK motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01214"
FT DOMAIN 1597..2107
FT /note="FMP27 WPPW motif-containing RBG unit"
FT /evidence="ECO:0000259|SMART:SM01216"
SQ SEQUENCE 2737 AA; 320217 MW; A05FEBF549B28757 CRC64;
MEIFVENILL WIGIFFLNYI LLTHILLKVI KKVGGVHIRR FGYFSIHGIE LCYKEYANLY
VESVRVHFHR PRLATKRWIS FSVKEIFINI RKPCKEREEI LKKKSSNNFF NKYIQKSIYF
VFNIMKSSII FKIKDWVDII IIDTSINIED YGKFFITTFN MHFNNTSYYN TTSGIYTGRF
SKLLSREKRF EMINIVDSIL FISKRGTSSE LIDKILINIQ GKLDHIIKNI KFSLKCGKFI
LPLDEFTNNN DINYFFNNKT DSFISTLNNY FKVKDESKEP IMELKENMVE KMHWFNIIHE
IQFHVGNLKI KKSITFSSSK NNSSFLLLRL KEIGINIHHI GKNSSIYRQF FDVPASHQIL
ASCISLSISI FQKTVQEKEA DFILIPMITF ACKISTLDHL VKSNMVTKGL HITNIIANIS
ITSPSIDLRF ERLLSIVSIF ESRNVIHTSV FSKLQLLKDF IPKLNFNFSI YEPVIRILLP
FNNSLYENSK QRPTILILSL SNIFLDLQTN ISGNDISRFF SVNTSILFIS QKLYYHTSFK
GKYNILTIEN FTLHFKFDLS PFNNVSIGIF HENVIFNLNN IEIIYCLNNI FYSISNIRYD
YLSEKNIGLL DMFLLYKCSL LLRKIEFHGS KLDIYLFGNE PRITHDHKGI LLRLDSWKIE
YCFLNMISKE LLFSIYKESK SPNFQHILNT FVFNTIPSSR GTLLLNGFKI FAIHAENVLD
MKEPIIEVIK YGLTFVTEPN KDHLLQIIIE LDQLCLTYSI FKYYTILLAL KILEKTFFQE
NIFKTSQGYH TEDNGQVNNL LWGYIFVYIS ISSVKVKIEL PSKQFLMLNM HKLEISHNKD
EFLSCKAGNI VLCVPSPVIQ KFWDRIVNIN TLTIYYKRIK IDQKNESTIV LYADAIRIRI
PHKFVLHSMV ESIQNNIKSV KQLYYCFFIS SNSSTLTNHP VKAKVIPRIQ LESSFISFDM
EDDPFEARLG LIWRIGLIEQ KARIMRETTF DIKAEKIKDE SELINDNEQT KTDNENEYFL
GTSFEKSELK QLYNKQDSHI KNVKDVQDFS ESKFSNLSSK AEQAYEKLQE YNSHSWIKKF
QKVNNLQSFK LYSIRHRHWT LDGIKCISTF QENILPLPTR PPLLSILFSK VEFIFDKPSF
PIENLYQFLR DTGKGLPLET KFSVLIPFNF SWKMAEAKIC LRDYPLPLIY IPDSNSLRPQ
NFPTWEFSSD LVIAEQFSEK ESIRYVEVCI IPNNSGKEGS SFNIKVARTI TPVKIYGVVD
VNINTLYPTQ ITWGMSLQPA IQDIMRIFGT FSRPFEDPSD KLNFWDKIRL IMHTSFKFKW
KNDGNVYLTL KGSRDPYLIT GDGAGFIKCW KGNVEWSVGC SLDSRNFMVI ISDEFLLAIP
DFIQQAQSLM NWPNTIISAY DNLTNNTYQK NAIHFQKIIM KLKGGVKWTA GLVFEQHCDD
ACQNCYGKYQ CRIFHFKPHY KIILRIPKFA FSENGQKYDA FKGFRSHYIH GSLSIICPID
VSLPDSKFNE KIKSYNAIHL TPKVFQHFFN WWSLFSGIMS FPLKSGKLFL FPHTKKKINR
YLMTFSYKLE LSPLFLSHIY NYRTDIDWVD KTFTSIGIKG KTEKFILDVH QKKDLQFKKL
HKTRKDEKLI IDNATINFTS TDLKVILSRF NEVDIEDSNK FRYDSQKSHD FRMIFQKNNS
NHFIVDEDLK WVDIDDFIDL DLDFSLKSAP VFQILPLAYI PQFIYFRETN NHCNGSGPEN
ICLSKYQFRN GDTHFCILNN KKDPYDIQVE LIQKRQNEIM RRISRNKNKL SCIENVISKK
SKASILKSQY KKIIDENAML FDKHNFINAM LLHMKADQDN KLTNEIDMSA DNHHISSDVS
ENFRALSKET ISEHFSDFNN RFFVYNIQLK WYNSVRNILL SYIHQITQRE GFVYYMSQKA
VKFITDLIKE QIKLENSLSM MTNEKIINKQ GFNDQEINEL IDGLINDTNN DFKDEKNNKK
SFSSIDNPFF RDDFDYILSK NYDCQHSYIV KLFAPQIQLQ SEKNNQAVAI ITAQNMQLKV
FSIIDKNMVD DTVSGLLQHR FIVKMNNAQI FVSKKNDFIE NSTNFFYTNS YGSLQSNWSP
WVPLESIYDF TGTPLAFTRI IDQTSASLGF IKYNHLRLKK NELNHNKNDL FESFKIESPE
KYVNNIFVDF PKIIFTANSD QYYIIFLIVT DLLIYTEPAQ KEKSKRLEKL MLAVDFSDLT
GTAEMVVNLQ KRIRNLEEIK TQHRLYYENY NMEQRLLRMK IEAELRDCED ELFYLMKSIA
ASQKHDGSII ENVANMSWLL SASEVVWHGL LENNKPFVDF GLSNATYQRT DNFDGSNFNI
LEIEMIQGIN LLPKTCFPDL LSPYFCGSKS VLHGRKKKMI RIYWHMLDSI GGIPVMDHFE
VNLFPLSIKL EHEVGKKIFD YVFPGRGVVN FIAQEKSSPL KKDINADISS TENYYKTDIS
RPFYSSRSSS FSLLMNSIKS PIESFSCLSK LSRESIKSNS SFQIFYDSED PYGIESLKLS
KSETQITDSN AFEKNSRISN KPYYKPNDDL NQMVLRANNN MTLLYVKVPS LILCLSYKGP
RKKNIEDLNN FVFCIPTIEY RNKTWSYLDL VLHIKKEIIK AIIGHTGSLV KDKFIQRRSR
EKLSQIKREY IPFKINMPLN YKNKNTELQK MSSNIIKSNL TKINCLHSNH KHHLHNFSER
SLSCVSHLVE YNDTEESEES RVKKAKMLLG KFIDPTV
//
