ID M7P0I1_9GAMM Unreviewed; 357 AA.
AC M7P0I1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE SubName: Full=Theronine dehydrogenase-like Zn-dependent dehydrogenase {ECO:0000313|EMBL:EMR12987.1};
GN ORFNames=MPL1_07553 {ECO:0000313|EMBL:EMR12987.1};
OS Methylophaga lonarensis MPL.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Thiotrichales;
OC Piscirickettsiaceae; Methylophaga.
OX NCBI_TaxID=1286106 {ECO:0000313|EMBL:EMR12987.1, ECO:0000313|Proteomes:UP000012019};
RN [1] {ECO:0000313|EMBL:EMR12987.1, ECO:0000313|Proteomes:UP000012019}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MPL {ECO:0000313|EMBL:EMR12987.1,
RC ECO:0000313|Proteomes:UP000012019};
RX PubMed=23661481;
RA Shetty S.A., Marathe N.P., Munot H., Antony C.P., Dhotre D.P.,
RA Murrell J.C., Shouche Y.S.;
RT "Draft Genome Sequence of Methylophaga lonarensis MPLT, a Haloalkaliphilic
RT (Non-Methane-Utilizing) Methylotroph.";
RL Genome Announc. 1:E00202-13(2013).
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947,
CC ECO:0000256|RuleBase:RU361277};
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. {ECO:0000256|ARBA:ARBA00008072, ECO:0000256|RuleBase:RU361277}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR12987.1}.
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DR EMBL; APHR01000037; EMR12987.1; -; Genomic_DNA.
DR RefSeq; WP_009726499.1; NZ_APHR01000037.1.
DR AlphaFoldDB; M7P0I1; -.
DR STRING; 1286106.MPL1_07553; -.
DR PATRIC; fig|1286106.3.peg.1516; -.
DR eggNOG; COG1063; Bacteria.
DR OrthoDB; 9773078at2; -.
DR Proteomes; UP000012019; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08285; NADP_ADH; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013149; ADH-like_C.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR002328; ADH_Zn_CS.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR PANTHER; PTHR42813:SF4; NADP-DEPENDENT ISOPROPANOL DEHYDROGENASE; 1.
DR PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF00107; ADH_zinc_N; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS00059; ADH_ZINC; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|RuleBase:RU361277};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Reference proteome {ECO:0000313|Proteomes:UP000012019};
KW Zinc {ECO:0000256|RuleBase:RU361277}.
FT DOMAIN 13..351
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 357 AA; 37854 MW; A6389CC65C3C40BD CRC64;
MAMMKAAVFV EPGRIEIEDK PIPDVGPNEA LIRITTTTIC GTDVHILKGE YPVAPGLTIG
HEPVGVIEKL GRNVQGYQEG QRVIAGAICP SFSSYACQDG CSAQDGGSHS HGYKPMGGWR
FGNTIDGAQA EYLLVPDAQA NLSPVPENLS DEQVLMCPDI MSTGFAGAES ANIRIGDIVA
VFAQGPIGLC ATAGARLRGA SLIIAVDGVD ERLTMAKQMG ADITLDFRKD DVVAEIMKLT
GGRGVDASIE ALGLQQTFES ALRVLKPGGT LSSLGVYSGN LTIPLDAFCA GLGDHKIITS
LCPGGKERMR RLMDIIASGR LDLGAMVTHR FKLEQIKEAY ELFSHQRDGV LKVAIET
//
