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Database: UniProt
Entry: M7P7X7_PNEMU
LinkDB: M7P7X7_PNEMU
Original site: M7P7X7_PNEMU 
ID   M7P7X7_PNEMU            Unreviewed;       821 AA.
AC   M7P7X7;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   25-OCT-2017, entry version 17.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=PNEG_01738 {ECO:0000313|EMBL:EMR09980.1};
OS   Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS   (Pneumocystis carinii f. sp. muris).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC   Pneumocystidomycetes; Pneumocystidaceae; Pneumocystis.
OX   NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR09980.1, ECO:0000313|Proteomes:UP000011958};
RN   [1] {ECO:0000313|EMBL:EMR09980.1, ECO:0000313|Proteomes:UP000011958}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B123 {ECO:0000313|EMBL:EMR09980.1,
RC   ECO:0000313|Proteomes:UP000011958};
RA   Rovira Torres L.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|EMBL:EMR09980.1, ECO:0000313|Proteomes:UP000011958}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=B123 {ECO:0000313|EMBL:EMR09980.1,
RC   ECO:0000313|Proteomes:UP000011958};
RG   The Broad Institute Genomics Platform;
RA   Cuomo C.A., Ma L., Huang D.W., Kutty G., Bishop L., Fantoni G.,
RA   Sherman B.T., Jiao X., Hu X., Yang J., Jones K., Raley C.,
RA   Stephens R., Lempicki R.A., Kovacs J.A., Chen Z., Abouelleil A.,
RA   Goldberg J., Priest M., Saif S., Sykes S., Young S., Zeng Q.,
RA   Wortman J., Nusbaum C., Birren B., Gabriel S., Lander E.;
RT   "Mechanisms of Adaptation to a Mammalian Host Environment by
RT   Pneumocystis, an Opportunistic Pathogen of Immunosuppressed
RT   Patients.";
RL   Submitted (JUN-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-
CC       ATPase), a multimeric enzyme that catalyzes the translocation of
CC       protons across the membranes. Required for assembly and activity
CC       of the V-ATPase. {ECO:0000256|RuleBase:RU361189}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EMR09980.1}.
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DR   EMBL; AFWA02000008; EMR09980.1; -; Genomic_DNA.
DR   RefSeq; XP_007873702.1; XM_007875511.1.
DR   EnsemblFungi; EMR09980; EMR09980; PNEG_01738.
DR   GeneID; 19895432; -.
DR   OrthoDB; EOG092C0YCY; -.
DR   Proteomes; UP000011958; Unassembled WGS sequence.
DR   GO; GO:0005783; C:endoplasmic reticulum; IEA:EnsemblFungi.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0015078; F:hydrogen ion transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0015991; P:ATP hydrolysis coupled proton transport; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629; PTHR11629; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000011958};
KW   Hydrogen ion transport {ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|RuleBase:RU361189};
KW   Reference proteome {ECO:0000313|Proteomes:UP000011958};
KW   Transmembrane {ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    418    442       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    463    480       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    542    562       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    574    593       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    633    651       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM    755    780       Helical. {ECO:0000256|RuleBase:RU361189}.
FT   COILED       53     80       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   821 AA;  95157 MW;  5BE8A0E00B2493FB CRC64;
     MASSTFYRSE EISMVQFYFP VEVAKLTVSA LGDLGIVQFC DLNENINIFQ RAFVKEIRRL
     DEVERQLQFL YEEIKKTDIK IITADNNDNM TRTSNCHEID EIFEKASFFE SRICSLNESY
     RTLEKQYLEL LELRYVLEET EQFFNKNYSI QESSISINDM DTAPLLENDA EQNTTNIQGL
     MGMSIGFTTG VIPRIHMATF ERILWRMLRG NLYMNQTEIA NPINDPITNE LIDKNVFIVF
     SHGKEINNKI RKISESLGAT LYNIDERYSR RCTHIQETNL AIDDLMSILK NTKQTVYAEL
     RIIAENIVNW ITIVRRERAI YQIMNLFIYD QNHKCLISEG WCPTNSLYLV RNTLRDVTEQ
     ACIQMPSILN EIKTSKTPPT FHSTNKFTKA FQTIIDAYGV ASYREANPGL IAIVTFPFLF
     AVMFGDLGHG FLIFIAALYL CLNEKKLEKK KYGEIFDMAF QGRYMILLMS IFSMYTGLIY
     NDIFSKPMSL FKSGWEWSES SGNSTVILAK KVGVYPFGID SAWHESENAL IFLNSYKMKM
     SVILGVIHMT FSLMLSLTNH IFFKSPLDIW TQFLPSFLFL QCIFGYMVFT IIYKWSVDWS
     KSQTTPPGIL NMLIFMFLSP GKIQEPLYRG QKYVQVFLLF ISLICIPWLL LAKPFVLRYE
     HRRAILQGYQ GVSNRCSSTL DDSDTDRTPL SSEVHEHFDF VEILIHQIIH TIEFCLGCLS
     HCASYLRLWA LSLAHNQLSA VLWSMTLKIA FRKTGITGAI LLVFVFAFWF ISTIVILCLM
     EGTSAMLHSL RLHWVEAMSK FYQGEGYPFE PFHLTNKFYD M
//
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