ID M7P9Q5_PNEMU Unreviewed; 825 AA.
AC M7P9Q5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 46.
DE RecName: Full=Importin N-terminal domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PNEG_01308 {ECO:0000313|EMBL:EMR10605.1};
OS Pneumocystis murina (strain B123) (Mouse pneumocystis pneumonia agent)
OS (Pneumocystis carinii f. sp. muris).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Taphrinomycotina;
OC Pneumocystomycetes; Pneumocystaceae; Pneumocystis.
OX NCBI_TaxID=1069680 {ECO:0000313|EMBL:EMR10605.1, ECO:0000313|Proteomes:UP000011958};
RN [1] {ECO:0000313|Proteomes:UP000011958}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=B123 {ECO:0000313|Proteomes:UP000011958};
RX PubMed=26899007; DOI=10.1038/ncomms10740;
RA Ma L., Chen Z., Huang D.W., Kutty G., Ishihara M., Wang H., Abouelleil A.,
RA Bishop L., Davey E., Deng R., Deng X., Fan L., Fantoni G., Fitzgerald M.,
RA Gogineni E., Goldberg J.M., Handley G., Hu X., Huber C., Jiao X., Jones K.,
RA Levin J.Z., Liu Y., Macdonald P., Melnikov A., Raley C., Sassi M.,
RA Sherman B.T., Song X., Sykes S., Tran B., Walsh L., Xia Y., Yang J.,
RA Young S., Zeng Q., Zheng X., Stephens R., Nusbaum C., Birren B.W.,
RA Azadi P., Lempicki R.A., Cuomo C.A., Kovacs J.A.;
RT "Genome analysis of three Pneumocystis species reveals adaptation
RT mechanisms to life exclusively in mammalian hosts.";
RL Nat. Commun. 7:10740-10740(2016).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMR10605.1}.
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DR EMBL; AFWA02000006; EMR10605.1; -; Genomic_DNA.
DR RefSeq; XP_007873234.1; XM_007875043.1.
DR AlphaFoldDB; M7P9Q5; -.
DR STRING; 1069680.M7P9Q5; -.
DR GeneID; 19895005; -.
DR VEuPathDB; FungiDB:PNEG_01308; -.
DR eggNOG; KOG1992; Eukaryota.
DR HOGENOM; CLU_009614_0_0_1; -.
DR OMA; AENEFLM; -.
DR OrthoDB; 178772at2759; -.
DR Proteomes; UP000011958; Unassembled WGS sequence.
DR GO; GO:0031267; F:small GTPase binding; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR005043; XPO2_C.
DR InterPro; IPR013713; XPO2_central.
DR PANTHER; PTHR10997:SF8; EXPORTIN-2; 1.
DR PANTHER; PTHR10997; IMPORTIN-7, 8, 11; 1.
DR Pfam; PF03378; CAS_CSE1; 1.
DR Pfam; PF08506; Cse1; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000011958}.
FT DOMAIN 14..383
FT /note="Exportin-2 central"
FT /evidence="ECO:0000259|Pfam:PF08506"
FT DOMAIN 386..821
FT /note="Exportin-2 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03378"
SQ SEQUENCE 825 AA; 95804 MW; 4AD9C6EAEBE9A416 CRC64;
MIVNLCILQT AHSIFGRWRS QFRSDSLFSE ILFVLEKFCT PYKNLFQRLD ELIMQNSENR
EALDLLFKNL ILCIKIFYDL NCQDLPEFFE DNIEQWMGLL HKYLNYSNPL LVSEDHDIEG
PLEKVKSNIC EIVELYTQRY EDAFSMLPEF VNTSWNLLTN TSFEKKNDIL VEKIMAFLTS
VAKIQRYSYI FKSQDVLRHL IENIILPNIS FQESDKEFFE DDSVEYVKRD LEEFDCNLRR
NATSNFVRAL LEQFETDVVS IVSTYINHYL VEFQKDKRKN WRAKNTAIYL FFSITIKSSA
NKLGVTSVTT ITNVVDFFSQ NIFQDLSLLS EDIHAMLKMI LIKYVYIFRN QLQRDQILSC
LPLLINYLNF PNYAVYTYAA VTIEAILNLN KEEGFLIEKM DIVQLSKELL DNLFKLIEKA
STLGKLSEND FLMKCTMRVI ATIKDGIIPL IDTISSYLIN IILEISKNPS NPKFNHYVFE
SLAILIRYSA PNSREILLRL ESSLFPSLRL ILQNDVTEFI PYVFQILSQL LEYHNLSLPD
IYKLLVPPIL LASLWESRGN VPALVRFLKA VISQDPLFIV NSNYIEQILG IFQKLNSSRL
DDHYGFELLE TVFLHLPASV IEPYVKQIFL LLLTRLNQSR TGKFVECFIQ LIFFLSAINK
KEYGPDYFIN VINNIQTGLF EQVFSMFCLP GVQNIKDTID RKTCSIGMII MLCRGSALQE
IKYPTLWSST LIAILKLFEL PFEVTKNDEI IEVDIDDIGF QASFSRLAFS VKAKQDPCMF
IKDPKAFLIE ELMKGNSANR GNFSRIISTM SDDVKTVLTT YGYII
//
