ID M7SAY4_EUTLA Unreviewed; 352 AA.
AC M7SAY4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Putative 1-aminocyclopropane-1-carboxylate deaminase protein {ECO:0000313|EMBL:EMR61327.1};
GN ORFNames=UCREL1_11747 {ECO:0000313|EMBL:EMR61327.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR61327.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate +
CC NH4(+); Xref=Rhea:RHEA:16933, ChEBI:CHEBI:15377, ChEBI:CHEBI:16763,
CC ChEBI:CHEBI:28938, ChEBI:CHEBI:58360; EC=3.5.99.7;
CC Evidence={ECO:0000256|ARBA:ARBA00001132};
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933};
CC -!- SIMILARITY: Belongs to the ACC deaminase/D-cysteine desulfhydrase
CC family. {ECO:0000256|ARBA:ARBA00008639}.
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DR EMBL; KB707654; EMR61327.1; -; Genomic_DNA.
DR RefSeq; XP_007799579.1; XM_007801388.1.
DR AlphaFoldDB; M7SAY4; -.
DR STRING; 1287681.M7SAY4; -.
DR KEGG; ela:UCREL1_11747; -.
DR eggNOG; ENOG502QPS1; Eukaryota.
DR HOGENOM; CLU_048897_2_1_1; -.
DR OMA; GIQSNHA; -.
DR OrthoDB; 5489296at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0008660; F:1-aminocyclopropane-1-carboxylate deaminase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0009310; P:amine catabolic process; IEA:InterPro.
DR CDD; cd06449; ACCD; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR InterPro; IPR027278; ACCD_DCysDesulf.
DR InterPro; IPR005965; ACP_carboxylate_deaminase.
DR InterPro; IPR001926; TrpB-like_PALP.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR01274; ACC_deam; 1.
DR PANTHER; PTHR43780; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED; 1.
DR PANTHER; PTHR43780:SF2; 1-AMINOCYCLOPROPANE-1-CARBOXYLATE DEAMINASE-RELATED; 1.
DR Pfam; PF00291; PALP; 1.
DR PIRSF; PIRSF006278; ACCD_DCysDesulf; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR006278-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174}.
FT DOMAIN 25..338
FT /note="Tryptophan synthase beta chain-like PALP"
FT /evidence="ECO:0000259|Pfam:PF00291"
FT ACT_SITE 90
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR006278-1"
FT MOD_RES 63
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR006278-2"
SQ SEQUENCE 352 AA; 37519 MW; F6B5207F3A9A3EEE CRC64;
MATTTAAAVV LPEPFASIPR ENFLFGPSPI QALPRISQAL GGKVQVFAKR EDCNSGLAYG
GNKTRKLEYL ASEALSQGCD TLVSIGGVQS NHTRQVAAVA AKLGLHSALV QEKWVAWEDP
GYTKVGNIQL ARLMGADSRL DPSAFGIEHK DTLKSMQKEL AAAGRKPYYI PAGASDHPLG
GLGFARWAFE VQEQERDLGL FFDTVIVCAV TGSTMAGMVA GFKLAEKLGA PKRKVVGIDA
SATVPQTFDQ VLRIAKATGA KIGLEEGDIT ERDIILDDRY HGGIYGVPDA QTIEAIKFGA
STEAFITDPV YEGKSLAGMM DMIRKGEIKE GSNVLYAHLG GQLALNAYSS IQ
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