ID M7SNA2_EUTLA Unreviewed; 1210 AA.
AC M7SNA2;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 54.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=UCREL1_5105 {ECO:0000313|EMBL:EMR67889.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR67889.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
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DR EMBL; KB706333; EMR67889.1; -; Genomic_DNA.
DR RefSeq; XP_007793016.1; XM_007794825.1.
DR AlphaFoldDB; M7SNA2; -.
DR STRING; 1287681.M7SNA2; -.
DR KEGG; ela:UCREL1_5105; -.
DR eggNOG; KOG0922; Eukaryota.
DR HOGENOM; CLU_001832_2_3_1; -.
DR OMA; DPMVAPE; -.
DR OrthoDB; 3682876at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:1990904; C:ribonucleoprotein complex; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
DR GO; GO:0008380; P:RNA splicing; IEA:UniProtKB-KW.
DR CDD; cd05684; S1_DHX8_helicase; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR049621; S1_DHX8_helicase.
DR InterPro; IPR003029; S1_domain.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF85; ATP-DEPENDENT RNA HELICASE DHX8; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF21010; HA2_C; 1.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR Pfam; PF00575; S1; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00316; S1; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
DR PROSITE; PS50126; S1; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000313|EMBL:EMR67889.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW mRNA processing {ECO:0000256|ARBA:ARBA00022664};
KW mRNA splicing {ECO:0000256|ARBA:ARBA00023187};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174}.
FT DOMAIN 243..314
FT /note="S1 motif"
FT /evidence="ECO:0000259|PROSITE:PS50126"
FT DOMAIN 554..718
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 736..916
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 76..110
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 136..235
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1210 AA; 136459 MW; 363157EA0981EC4A CRC64;
MDDLEELELL SLVSKVTSEL QNHLGISEKT LAEFIIFQRL GCSFSEWKTK LADMGGASWP
ESLYDSVDRL VTTMHPKFKG SHNGATGSDD RPTRSQQEKE SIFKGLSIPD REVAAQEDAD
AIDDTLALLE GLEGKARDTR VEPERASRKR SRSPDGVDAA DSRHRRKERY RSRERRDKDY
GEDDDYKDRK ARKERRRRRD DYDDNDGYRS ERKERRRRDY NDEDDDRLRR APEPEVDDSP
VLYKVYDGHV TGIKDFGAFV NLHGVQGKVD GMIHISNLTQ GQRVNHPSDL LSKGQSVKVK
VTKLEGNRIG LSMKDVDQET GMDLQPQARI ETGANMEALG SRGLGGHVET QLDALSKHAS
QPRQHKKRMT SPERWEIRQL IASGVAKASD YPGLEEDYNA TLRGDGEMEL EEEVDIEVRE
EEPPFLTGQT KQSLELSPIR VVKAPDGSLN RAAMSGAGIA KERKEMRQQE AEVAEQESKT
DLSQQWQDPM ANPDQRRFAS DLRNTKANAA KPEAVPEWKR AIAPKDQSFG KRTTMSIKQQ
RESLPVYAFR NQLIDAVKQN QILIVVGETG SGKTTQLTQF LAEAGFTENG VIGCTQPRRV
AAMSVAKRVA EEVGCQLGQE VGYTIRFEDC TSPSTKIKYM TDGMLQREIL VDPDLRRYSV
IMLDEAHERT IATDVLFGLL KKTLKQRRPD LKIIVTSATL DAEKFSSYFN ECPIFTIPGR
TYPVEILYSR EPESDYLDAA LVTVMQIHLT EPAGDILLFL TGQEEIDTAC EILYERMKAL
GPNVPELLIL PIYSALPNEM QSRIFDPAPP GSRKVVLATN IAETSITIDH IYYVIDPGFV
KQNAYDPKLG MDSLVVTPIS QAQANQRAGR AGRTGPGKCF RLYTEAAFQT EMLPTSIPEI
QRQNLSMTIL MLKAMGINDL IHFDFMDPPP TNTMLTALEE LYALSALDDE GLLTRLGRKM
ADFPMEPSLA KVLIAATDLG CSDEILSIVA MLNLQTIFYR PKEKQQQADQ KKAKFHDPHG
DHLTLLNVYN AWKQSGFSAP WCFENFIQAR SMKRAKDVRD QIIRIMERYR HPIASCGRDT
QKVRQALCAG FFRNAARKDP QEGYKTLIEG TPVYLHPSSA LFGKQAEWVI YHTLVLTTKE
YMHCTTSIEP KWLVQAAPTF FKVAPSDRLS KRKKAERIQP LYNKFAGEDD WRLSAQRKTG
RSGGGGGTWG
//
