ID M7T332_EUTLA Unreviewed; 3831 AA.
AC M7T332;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE SubName: Full=Putative histone acetylase complex subunit protein {ECO:0000313|EMBL:EMR64226.1};
GN ORFNames=UCREL1_8813 {ECO:0000313|EMBL:EMR64226.1};
OS Eutypa lata (strain UCR-EL1) (Grapevine dieback disease fungus) (Eutypa
OS armeniacae).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Sordariomycetes;
OC Xylariomycetidae; Xylariales; Diatrypaceae; Eutypa.
OX NCBI_TaxID=1287681 {ECO:0000313|EMBL:EMR64226.1, ECO:0000313|Proteomes:UP000012174};
RN [1] {ECO:0000313|Proteomes:UP000012174}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=UCR-EL1 {ECO:0000313|Proteomes:UP000012174};
RX PubMed=23723393; DOI=10.1128/genomeA.00228-13;
RA Blanco-Ulate B., Rolshausen P.E., Cantu D.;
RT "Draft genome sequence of the grapevine dieback fungus Eutypa lata UCR-
RT EL1.";
RL Genome Announc. 1:E0022813-E0022813(2013).
CC -!- FUNCTION: Serine/threonine protein kinase which activates checkpoint
CC signaling upon genotoxic stresses such as ionizing radiation (IR),
CC ultraviolet light (UV), or DNA replication stalling, thereby acting as
CC a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-
CC Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of
CC DNA damage, involved in the regulation of DNA damage response
CC mechanism. Required for the control of telomere length and genome
CC stability. {ECO:0000256|ARBA:ARBA00025079}.
CC -!- SUBUNIT: Associates with DNA double-strand breaks.
CC {ECO:0000256|ARBA:ARBA00011370}.
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DR EMBL; KB707110; EMR64226.1; -; Genomic_DNA.
DR RefSeq; XP_007796678.1; XM_007798487.1.
DR STRING; 1287681.M7T332; -.
DR KEGG; ela:UCREL1_8813; -.
DR eggNOG; KOG0889; Eukaryota.
DR HOGENOM; CLU_000129_1_0_1; -.
DR OMA; CLDLYGQ; -.
DR OrthoDB; 3666795at2759; -.
DR Proteomes; UP000012174; Unassembled WGS sequence.
DR GO; GO:0006325; P:chromatin organization; IEA:UniProtKB-KW.
DR CDD; cd05163; PIKK_TRRAP; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR046807; Tra1_central.
DR InterPro; IPR046805; Tra1_ring.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF1; TRANSFORMATION_TRANSCRIPTION DOMAIN-ASSOCIATED PROTEIN; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF20175; Tra1_central; 1.
DR Pfam; PF20206; Tra1_ring; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 4: Predicted;
KW Chromatin regulator {ECO:0000256|ARBA:ARBA00022853};
KW Reference proteome {ECO:0000313|Proteomes:UP000012174}.
FT DOMAIN 2647..3202
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 3476..3802
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 3799..3831
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
FT REGION 161..199
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1998..2035
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3210..3304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3223..3297
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3831 AA; 437611 MW; C6C248B4E9C60C12 CRC64;
MSGAAFDDIV KRLTTQETEP KAKLDAAIAL RDSLDHYTNG PNYGHFLKRV MPLFIIILRG
PCIFQSTSPE QKLRNCILEI LHRLPTHQTP SEPFEPYAEE IVDLLMTLVR SDNEDNATLC
VKIISDIMRH QPKVLHPKVQ AFLSLIQELF EQMEKVVREQ LDSTSLNPSA AGPPSTPGST
QTNFQSPRPG SPVASVTDLG QDLQQQSRPL LKGMQSFKHN VKAFVPLIKS VLCLQAKAQE
QAHTEARGRG VVFAGVSPNI KNRAAFGEFI TAQVKTMSFL AYLLRQYSSQ LADFLPTLPE
IIVRLLQDCP REKSAARKEL LVAIRHIINF NFRKIFLPKI DELLEEKTLI GDGLTVYDTM
RPLAYSMLAD LIHHVRDSLS PAQIRKTVEV YTRNLQDNFP GTSFQTMSAK LLLNMAECIA
KMQNKVDARH YLLMILNAIG DKFAAMNRQY PNAVKLSKLY KQQASEQAPD TYLADKEHPP
EWDETDIFTA MPIKTSNPRD RHADPVNDNK FLFKNLMNGL KNTFYQLKTC NTASQVDDNN
APAHWKEVSY GFSAEEVKVI VKLFREGAYV FRYYEIEKPA AESQYASPVE YMANFYMVSS
SKEEKDLLET FATVFHCIDP ATFHEVFQQE IPRLYDMIFE HTALLHIPQF FLASEATSPS
FCGMLLKFLM ERIGDVGSAD VKKSSILLRL FKLAFMAVTL FANQNEKVLL PHVVDIVTKS
IDLSTKAEEP MNYFLLLRSL FRSIGGGKFE HLYKQILPLL EMLLDVLNTL LMAARKPAER
DLYVELCLTV PARLSNLLPH LSFLMRPLVV ALRAGTDLVG QGLRTLELCV DNLTADYLDP
IMAPVIEELM NALFEHLKPH PYSHFHAHTT MRILGKLGGR NRKFMTDSLP VNYQKYADDP
SSFDVRLIGS KKDRAFPAEL GIDFAIRKLM EVPKPSKTPT TKQLDSYYKR QALQLIKSQM
KLRIGFDSLP EDLPRLVRLQ AQDLLLRKPA AEVSTFDTSD RERSVVKKNE QDEIMKRLLK
AIMFAESLPE FREEADVFLM NLCRHFTIIE IGRGLVDVKR ELSPFDPKAG EGPLVIDTRI
LANAIVESLS SDLPDVRDAA FRAMRAVYDS TTTIFGSETH VGRLGVFNHL SKTFCHGCHE
EEWYTKTGGT LGIKYLLTEV DLGDGWVASK QMDFVKALMY VIKDMPQDLP QKTRGFAQIT
LEALLKRITK NVKKEDALPL PTGQPASKMP RLSQICILFN DELSHMNSHV RETARRSLEI
IANAAGAEIW VIVEPCKDRL LQPIYAKPLR ALPFSTQIGY IDAIAYYMSL KSDFVAFDDN
LNRLLMESLA LADATDESLA GKPAEFRTHE SIVNLRVACI KILSKAMGFD EFQRGPNNAT
RTKIVSVFFK CLYSESKPTI EAANDALKAV LSQTNKLPKD LLQQGLRPVL ANLQDPKRLS
THGLDNLARL LRLLTTYFKV EIGARLLDHI KVLAEPNLMQ QLSFTFFEQN GTMKVISAVF
NIFYLLPPAA EQFKDRLIDT CLELEEKLRR THHSPFRQPL YRFLNRYPTE IWDYLLNKME
DLKYGRFLSQ VLLHPESKHL REYASSHVPQ LIAWCNQIVA NSKETRFIAV INTISVLDAL
SQDATRQSWM ERKDTIAWLK QVGKDLERHL RANQLFPNLR LPADQAAEQL VGIFTRALAL
NPNDLDPLFN LIESVTAEEF RATPTLYSYI YDNVICSDSI EFWKSVILRC LDIYADKNST
QKAKCFLLRN VLNPIVAMDI MRHWNKPIQP KVPRLMDRAV IESINMKVWK VNLGDPQEDL
LQPGIDHTRM EVLQLSAMLV KYHHAILQDA RKDIIKFGWT YIRLDDVINK HAAYVVIGYF
IAHYETPPKI VTQVYYSLLR TNQNEGRALV TQALELMAPV LPKRCNAMPG DRNAVWAMAP
RRILAEEGQN VQQMTSIFHF LVRHPDLFYE SRDKFALLII TSLRKVSAPQ ASVNESKKLA
LNMMWLIWEW EQRRVEGKPS DFPKSLSESP SSKKRRLELD SPPAVRQQSA HAERSEFQIP
PGFRLKMVKY LIEFIAQLNE RYQLPSAKPR EAAPTSGPAL PPQSTDLCKK AMALLYNLMQ
PQYWGDLDVD LFPNITEVIL ASEKTSKILA ADPSDKENYD EKFITNIVNT LQVVRTILNF
KSDEWILKNM TSVQKVLEKC LKSDNPELQD CLHLADKTYD DNRDVKSTVQ RVLDAIPEDV
PMEDADAEGE SEAPTSEIIT FLSGIATETL AASNYISGVN VLWSLGQRKP SVIDQHIAAL
MKALQTKLAR EHVQHYASVA THQMSIAPIR PQDPNAQAGE LSPYDLNVQT SLMIKAIQVT
AMRMEILGDN RRPFLSVLAT LVEKSHHTPL CEKILEMVEG WVFRSEGTWP TLKEKTAVLH
KMLSFEHRAD STMLTKFLEL VIRIYEDPKI TRTELTVRME HAFLIGTRAQ DVGMRNRFMA
IFDKSLSKTA SARLSYVIAS QNWDTLADSF WLAQASQLLL GAVEANSSAQ LHQEDFRMLP
ASQIFGTYAK DIREPNNMID DKYETFMGNH RRFVAELGDV KVRDIFEPLA QLQHVDNSLA
SELWVTLFPM YWSATAREEK TDLEKGMVVL LTKDFHSRQI DKRPNVVQAL LTGAAKAWPE
CKIPPHVLKF EAKTYDAWYT ALVQLENATI KPDVDSPNVR ESTLDALVEL YSSLKEDDLF
YGTWRRRCQF VETNAGLSYE QMGMWDKAQK MYEAAQIKAR TGVIPFSQGE YMLWEDHWVL
CAEKLQQWDI LQDFAKHENL QDLLLECCWR SIDMWQNQEH RDSLEGVIKG LMDAPTSRRA
FFQGFMSLLK FHNKQETGPE FSRVCDEAIQ LSIRKWHQLP KRLTAAHIPM LHNFQQLVEL
HDASVICQSL ASTTQQNLDV KSGELKLLLG SWRDRLPNIW DDITDWQDLV TWRQHIFGLI
NSTYLQLLPS QGQNANGASF AYRGYHETAW IINRFAHVAR KHNLPEVCIS QLSRIYTLPN
IEIQEAFLKL REQARCHYEN PDELTSGLDV INNTNLNYFN NQQKAEFYTL KGMFLEKLKQ
KEEADAAYGT ALYYDIGKAK AWAEWGYFND RKFKEDPTDL NSARQAVTSY LQAIGSYKSG
KARKLISRIL WLLSMDDVNG TIAAGFDDYK GETPVWYWIT FIQQLLNGLS HKEAPKVHAI
LLKIAKAYPQ SLYFQLRTSR EDMLAIKKNQ EAKEKARQRA QSAAAKPNGS PAQPKQETAQ
AKTESSSRPQ TANGDASTQP KTEASETNRT SSIPPAGNTV SAPGTDQQPS KDGASSTAGQ
KKPPWELTEE IMSVLKTAFP LLALSMETMV DQIQKFFKCP PDEDAYRLIV ALLNDSLAYV
SRMPSSYAKD VKLPSATEIN ITRFAETILP AHIKKSFEVD FVVVKPTMYE YIHKLRRWRD
KFEEKLDRRD PKAYLEGYSR HLSDFRYQKF DDVEIPGQYL QHKDKNQDFV RIDRFLPNVD
LVRSIGTSHR RLKIRGHDGS VHCFAIQHPA ARHSRREERV LQLFRHLNQT LAKKKESRRR
DLQFTLPLMV PLAPHIRIVQ EDTSYITLQG IYEDHCRRNG MQKDEPVLFT MEKLRGLIEP
KGSKQPDQTA TARLEVFTAI QEKWVPHHIV LDYFQSIFPE FAEFWLFRRR FSYQLSALTF
MTYILYMTSR YPHKINIARG SGKIWGSELM SYMAATKPFF HNPEPVPFRL TPNLQTLMGP
LATEGIFSPS IMAIARCLTE PEFELEHALT LFVRDEMIWW FTNSHRTAHL TETQLRDTVQ
TNCDMIVKRA VSLAQCPVGN LPACQTVIDL IAKAVNPVHL AQCDALWMPY L
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