ID M7TSV1_BOTF1 Unreviewed; 923 AA.
AC M7TSV1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE SubName: Full=Putative dna mismatch repair protein {ECO:0000313|EMBL:EMR86681.1};
GN ORFNames=BcDW1_4690 {ECO:0000313|EMBL:EMR86681.1};
OS Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR86681.1, ECO:0000313|Proteomes:UP000012045};
RN [1] {ECO:0000313|Proteomes:UP000012045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT grape berries.";
RL Genome Announc. 1:E0025213-E0025213(2013).
CC -!- FUNCTION: Component of the post-replicative DNA mismatch repair system
CC (MMR). {ECO:0000256|RuleBase:RU003756}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutS family.
CC {ECO:0000256|ARBA:ARBA00006271, ECO:0000256|RuleBase:RU003756}.
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DR EMBL; KB707850; EMR86681.1; -; Genomic_DNA.
DR AlphaFoldDB; M7TSV1; -.
DR STRING; 1290391.M7TSV1; -.
DR HOGENOM; CLU_002472_10_0_1; -.
DR Proteomes; UP000012045; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:InterPro.
DR CDD; cd03285; ABC_MSH2_euk; 1.
DR Gene3D; 1.10.1420.10; -; 2.
DR Gene3D; 3.40.1170.10; DNA repair protein MutS, domain I; 1.
DR Gene3D; 3.30.420.110; MutS, connector domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR011184; DNA_mismatch_repair_Msh2.
DR InterPro; IPR007695; DNA_mismatch_repair_MutS-lik_N.
DR InterPro; IPR000432; DNA_mismatch_repair_MutS_C.
DR InterPro; IPR007861; DNA_mismatch_repair_MutS_clamp.
DR InterPro; IPR007696; DNA_mismatch_repair_MutS_core.
DR InterPro; IPR016151; DNA_mismatch_repair_MutS_N.
DR InterPro; IPR036187; DNA_mismatch_repair_MutS_sf.
DR InterPro; IPR007860; DNA_mmatch_repair_MutS_con_dom.
DR InterPro; IPR032642; Msh2_ATP-bd.
DR InterPro; IPR036678; MutS_con_dom_sf.
DR InterPro; IPR045076; MutS_family.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11361:SF35; DNA MISMATCH REPAIR PROTEIN MSH2; 1.
DR PANTHER; PTHR11361; DNA MISMATCH REPAIR PROTEIN MUTS FAMILY MEMBER; 1.
DR Pfam; PF01624; MutS_I; 1.
DR Pfam; PF05188; MutS_II; 1.
DR Pfam; PF05192; MutS_III; 1.
DR Pfam; PF05190; MutS_IV; 1.
DR Pfam; PF00488; MutS_V; 1.
DR PIRSF; PIRSF005813; MSH2; 1.
DR SMART; SM00534; MUTSac; 1.
DR SMART; SM00533; MUTSd; 1.
DR SUPFAM; SSF48334; DNA repair protein MutS, domain III; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00486; DNA_MISMATCH_REPAIR_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|RuleBase:RU003756};
KW DNA repair {ECO:0000256|RuleBase:RU003756};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU003756};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU003756}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
FT DOMAIN 729..745
FT /note="DNA mismatch repair proteins mutS family"
FT /evidence="ECO:0000259|PROSITE:PS00486"
SQ SEQUENCE 923 AA; 103888 MW; 6498D9B78F76FA8F CRC64;
MSSRPELKVD DELGFIKFFT NLPQRDGETI RVFDRGDFYT AHGDDATFIA RTVYKTTSVL
RDLGSNSTKI PSVTMTVTVY KNFLREALYR MGKRVEIFTT SGRNNWKVTK TASPGNLQDV
EEELGGSFDA APIILAVKVS AKASEARNIG VCFADASVRE LGVSEFLDND LYSNFESLLI
QLGVKECLIQ VDRTTKDVEL QKLKQIIENC GCAWTERAGG TFGTKDIEQD LARLLKDEKS
TGVIPQTDLK LAMGSAAALI NYLGVLHDNS NFGQYQLYQH DLSQFMKLDA SALKALNLMP
GPRDGSKTMS LYGLLNHCKT PVGSRLLAQW LKQPLMSLEE IEKRQQLVEA FVEDQELKQT
IQETHMRSIP DLYRLAKRFQ KKLANLEDVV RAYQVVIRIP DLIKTLEDVM DEKYRDALDE
AYTDKLRGCN VSLGNLAEMV ETTVDLEAMD NHEYIIKHEF DDSLNIIRRK LDKLKYEMDQ
EFRIVAKDLG QEIEKKIFLE NNKVHGWCMR LTRTEASCIR NKSKYQECQT QKNGVYFTTS
KLLSIRREFD QLSENYNRTQ SSLVNEVVAT AASYCPVIEQ LASVLAHLDV IVSLAHTSAH
APTSYVRPKM HPRGTGSTIL KEARHPCMEM QDDVQFITND VSLIREESSF LIITGPNMGG
KSTYIRQIGV IALMAQIGCF VPCSEAELTI FDCILARVGA SDSQLKGVST FMAEMLETAN
ILKSATSESL IIIDELGRGT STYDGFGLAW AISEYIVREI GAFSMFATHF HELTALADTF
PQVKNLHVVA HIDTEPSSQE RKREVTLLYK VEEGICDQSF GIHVAELVKF PEKVIGMARR
KAEELEDFGT SVKADNGDPS SQEYAKEDVE EGSRLLKDIL KKWKAEIDGK EMAKEDKIAV
LRRLVGGDER LRANPFFKSI ECL
//
