ID M7TV65_BOTF1 Unreviewed; 1789 AA.
AC M7TV65;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=BcDW1_6170 {ECO:0000313|EMBL:EMR85175.1};
OS Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR85175.1, ECO:0000313|Proteomes:UP000012045};
RN [1] {ECO:0000313|Proteomes:UP000012045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT grape berries.";
RL Genome Announc. 1:E0025213-E0025213(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
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DR EMBL; KB707917; EMR85175.1; -; Genomic_DNA.
DR STRING; 1290391.M7TV65; -.
DR HOGENOM; CLU_000335_0_4_1; -.
DR Proteomes; UP000012045; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR CDD; cd18795; SF2_C_Ski2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR Gene3D; 1.10.3380.10; Sec63 N-terminal domain-like domain; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR004179; Sec63-dom.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR47835; HFM1, ATP DEPENDENT DNA HELICASE HOMOLOG; 1.
DR PANTHER; PTHR47835:SF2; SEC63 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF02889; Sec63; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SMART; SM00973; Sec63; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF158702; Sec63 N-terminal domain-like; 1.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000313|EMBL:EMR85175.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 451..625
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 668..853
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 51..122
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 160..237
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 303..379
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1371..1434
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1498..1569
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1685..1763
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 167..186
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 187..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 305..379
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1400..1414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1502..1519
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1526..1559
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1692..1720
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1789 AA; 198519 MW; 440AB9FED5C2F447 CRC64;
MDRSWDPHLQ RIANGTIGNT SDGVPHHEDG KDAGFSTNFF IGKDSQQLPP GPGFTFGPSP
MQHNQQVSGP YGQDVDVRGR YNNTGGHNQS SGYLMAPREE PPTAGFSFAP APRQPGQRMS
SLGQNTDVRA SYDLPVHDPL QGYLSRPSFE LSQPMQRLAP HSTAGIGNGQ GRLSLPRFSS
HVGGQAQSKA RERKEPRDLT STDDHFKQQI LQDIELKPKP RNIPARLSNS GVGEGQSPLT
QLANNMISQT SMLMPRALGL SPSKQNIFQS QLERPLQFQQ KNQQVSTPPS TRMDLGAFAY
KPPERMNTTL NSSPLQLPVS SPSARVSSRR NSNRRLPPHN TKETGQGFEH QYTAPHTPHN
QASPSNRYAL SSTASQAQEM GRGVETFGFS PAKTYPGSVG QFKNDHQIIP FGNGPPKAHG
IQLVSPHELP DRFRQVFPYE LFNAVQSKCF AQIYKTNNNI VISAPTGSGK TALLELAICK
LVESYGSGQF KIVYQAPIKS LCSERMRDWT KKFSHLNLPV AELTGDTSNA EMSRVGNASI
IITTPEKWDS ITRKWTDYQK LLQLVKLFLI DEVHILKDAR GATLEAVVSR MHSIGASVRF
VALSATVPNA HDIATWLGRD SSSRQLPAHR ETFGEEFRPV KLQKHVHGYE SRANDFAFEK
ILDGKLPALI QKYSCKKPIM IFCFTRKSCE VTATILAEHW TRQRVVDRAW PTPTTRTVVG
SKDLQELVGC GVAYHHAGLD AQDRCAIETA YLKGDISVIC CTSTLAVGVN LPCHLVVLKG
TVCFQDSGLV EYSDLEVMQM LGRAGRPQFD DSAIAIIMTR MDKADRYKKM ISGQDILEST
LHLNLIEHLN SEIGLRTIKT AYEAKVWLGG TFLSVRMRQN PKYYKFSGVA PSRDADEQLE
LVCERDIKLL QEYELVTKEE NFSCTDYGAA MSRYMVQFET MKLLLSIPRH SKTEVILNTI
CQAAEFKDLR MKPNERSSLR EFNKSPMMKF PIKENISTTG HKIFLMIQVQ LGGIEPLTNN
DFRVISRQFA METNIILERF QRLIRCVIDC KAVDCDSISV RCALDLSRSV AANYWENSSL
QLRQVPQIGP ASLRKLAGNN VNTIEKLSGL DTAGVERVMG KNPPFGKKMK DILIEFPQLT
LTAQIVGRAF SKQGEQPKVK VNAVLGYSNP KIPNWSGRIP SITFIAETSS GTLVFFWRMN
IKKLSNGGSK QEFTVELSSP DDEIKCWLAC DEIVGTLKSC VLQHHVPASE FPPPKAMIER
PSIKRSKAQE LGICDEFNDG IDEDAMLAVA KQIEGGRRAS SDYGSDAFID IDTVGLDNSK
ENKKFNEEVV ELEPVKMENG KWACNHHCRD GNTLKNGQIC KHRCCREGLD KPRKVTRKKS
STGITGDQGS KIDDKIKGSV TKPSMSNPQP PGMKQLSKLT KKPKLMQSSG PSSDQDIVEV
VDLSRTLLPV TYPDVAPRDY RKLHNLHTSI QKDTSVRLPK GQPRFSYASG KMPNFSFMYN
DGSKNDEKDE PEHFDSDEYE FPSPSALLSS EKQASKGVSI SATQLPPPAM SVDISRQDGN
EQQAHSDDPF EDSFGSLEAA MIGLDDSINL RTGPAAPNAP ATPKLNTSFA NNVFDFAAFN
SEEVNEQQFS SPLMNQIQRK HQEGEMDEMD IGMPSIKRQQ SSPWMKDFQN GDVMGYDQWG
ENENEGYDGP VLPQMKRRKI DGGDEDGDRG GMESIGKDPE DALKSTSGSS APAWANKTGS
GIMGSDIGNG GDDEQKGNLK ANVRQEPAWV GEMDPDFIDM FRGYVDFVD
//
