ID M7U5Z5_BOTF1 Unreviewed; 1620 AA.
AC M7U5Z5;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 38.
DE RecName: Full=E3 ubiquitin-protein ligase listerin {ECO:0000256|ARBA:ARBA00017157, ECO:0000256|RuleBase:RU367090};
DE EC=2.3.2.27 {ECO:0000256|ARBA:ARBA00012483, ECO:0000256|RuleBase:RU367090};
DE AltName: Full=RING-type E3 ubiquitin transferase listerin {ECO:0000256|RuleBase:RU367090};
GN ORFNames=BcDW1_9299 {ECO:0000313|EMBL:EMR82023.1};
OS Botryotinia fuckeliana (strain BcDW1) (Noble rot fungus) (Botrytis
OS cinerea).
OC Eukaryota; Fungi; Dikarya; Ascomycota; Pezizomycotina; Leotiomycetes;
OC Helotiales; Sclerotiniaceae; Botrytis.
OX NCBI_TaxID=1290391 {ECO:0000313|EMBL:EMR82023.1, ECO:0000313|Proteomes:UP000012045};
RN [1] {ECO:0000313|Proteomes:UP000012045}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BcDW1 {ECO:0000313|Proteomes:UP000012045};
RX PubMed=23704180; DOI=10.1128/genomea.00252-13;
RA Blanco-Ulate B., Allen G., Powell A.L., Cantu D.;
RT "Draft genome sequence of Botrytis cinerea BcDW1, inoculum for noble rot of
RT grape berries.";
RL Genome Announc. 1:E0025213-E0025213(2013).
CC -!- FUNCTION: E3 ubiquitin-protein ligase. Component of the ribosome
CC quality control complex (RQC), a ribosome-associated complex that
CC mediates ubiquitination and extraction of incompletely synthesized
CC nascent chains for proteasomal degradation.
CC {ECO:0000256|RuleBase:RU367090}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU367090};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|RuleBase:RU367090}.
CC -!- SUBUNIT: Component of the ribosome quality control complex (RQC).
CC {ECO:0000256|RuleBase:RU367090}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the LTN1 family. {ECO:0000256|ARBA:ARBA00007997,
CC ECO:0000256|RuleBase:RU367090}.
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DR EMBL; KB708057; EMR82023.1; -; Genomic_DNA.
DR STRING; 1290391.M7U5Z5; -.
DR HOGENOM; CLU_000471_0_0_1; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000012045; Unassembled WGS sequence.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:1990112; C:RQC complex; IEA:UniProtKB-UniRule.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043023; F:ribosomal large subunit binding; IEA:UniProtKB-UniRule.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR GO; GO:0072344; P:rescue of stalled ribosome; IEA:UniProtKB-UniRule.
DR GO; GO:1990116; P:ribosome-associated ubiquitin-dependent protein catabolic process; IEA:UniProtKB-UniRule.
DR CDD; cd16491; RING-CH-C4HC3_LTN1; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR039795; LTN1/Rkr1.
DR InterPro; IPR039804; RING-CH-C4HC3_LTN1.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12389:SF0; E3 UBIQUITIN-PROTEIN LIGASE LISTERIN; 1.
DR PANTHER; PTHR12389; ZINC FINGER PROTEIN 294; 1.
DR Pfam; PF13639; zf-RING_2; 1.
DR SMART; SM01197; FANCL_C; 1.
DR SMART; SM00184; RING; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU367090}; Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU367090};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU367090};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU367090};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1567..1613
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT COILED 1177..1204
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1620 AA; 181232 MW; EEFBDF6C7E406423 CRC64;
MGKRQFKSQA SSTRASTATG AGFGFGFTTK ATRLSYLTEP SNLSAISDAN VILSFKNLSK
KDATTKSKAL EDLRTFVQNQ PNEQGGTEEA ILEAWVDAYP RISIDNSRRV RELSHSIQYE
LLKSARKRME RYIPKVVGSW LAGTYDRDRA VARSAMDGLT SFLDTDAKMN LFWKRCQNEI
LDYAEEALNE TPNTLSDERS VPTEEANEKY FRVNSASVSL LANLLAKLGD DDMLKYQDRY
EKVIFGNKKL WTLASCEDAT ARKSTDKLLV LCLEKQTQLV ENNLGTISRA FISEALRSSQ
LTSALQLLQT LHQLTKQFPQ VWTSAYKAKR STATGDLISF VQKGSQGSSP AYWQTLRALV
AILPISVLPQ TPDSILEFLE VFRKSINQRE ESRANSSEAW LAYGETSNIC IVNLPSSQQA
EIVQKSTYPM FAHYLHPSPE TSEWLIRNNT PSSTISAFIS RLGKNSNLQN SLAEEWQKLA
QEFVTRIQTS MPEQSKDYSS SQDAVMAEGH RWFSLLSDIF KLKDLTVDQN PLLQPSGHII
DSTLQVIISR NGKPYSAGAV LESALRYSPQ LMEASPSILE TVKSFMETHL PKLLLSPSSS
YLTSSLDQFR LISGQQDSYK SIWQTAIDAL LSTPRNLQRQ KTITALISSN DISDLVRDDQ
ALQDLLLETS RDVVEGNNDE WALFEAAVIF NGFSKPTERL LLQNLISVLN ASNPNVNHVF
QALELLSKRR PEAIRDGDAH VDLITKLLAL TELSDSDLGK RATNLRSVVD NESGATTSSV
VHILRENLEN ANPQSLTIDT LVQQAEAIIT TLDDSSHHPE LFPNATKWSE ALAPLLDQAP
NPTLGVMRPF AGAVFLARAQ SGNDGSRPGR DLDGYSVALR MAMYSAHLIR DHPDRLSKDA
LVEIIYLMCL TVELANDQLD LLENNKLFVL SSEEAIAGVR DFVDRIYQDS WSFIVLHSKA
WQDGFESGSP LEFSGVVHTL ISKLINTSCG NTSTSFYSAR VLSHLLPKLV EQHGWQVGGE
DWISSLDILK SSTSNIFGAV AILTGLHETL SSSQLVSNLC NRIISDVAGA NAQSEETLGR
LVLLNATLSV YDNDDLPVAQ NRLVFAVKQI LSWTPEISDT NYQLSSESCL ALQKLLPAIK
SVYGSYWEKT LEFCIKIWES MENEDHQDQK LPMMGMALKL FSNLQSLQDA NDDLEDARAQ
YGETASHCLI KLTKLPRSKS TQPIEFVDNI LSRLVINIPS SHINDISEFY PLVASENRMV
QSAAFSVLHR AIPAEQAEIS VNVLLEKKDA QLPEELLSLL LDAPSIRNFD DEELAEFPPS
IRSYLLSWHL VYDAFSTASW KVRKDYCNHL QSENCLGSFL TFLFDVLGHS DGTPLNLEKA
HFDESYIRTY DTSLADGETN ERNFQWLLIH LYHLCLRHTG DLAKAWFSDC QSKQTRQAVE
TWTEKYFTPL LISDKLDEID EWATSKEAKE GGEKELEIKT SKGARSIFAS YEIDDTSIQI
AIRFPSNYPF YNVKVEGINR VAVPEKKWRS WLLIVQGAIT FSNGSLIDGL TTFRRNVEGS
LKGHTECAIC YSIISSDKKT PDKKCGTCKN TFHGQCLFKW FASSNQSSCP LCRCAFNYGR
//
