ID M7VZS9_ENTHI Unreviewed; 661 AA.
AC M7VZS9;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=Ubiquitin ligase E3a, putative {ECO:0000313|EMBL:EMS13512.1};
GN ORFNames=KM1_178210 {ECO:0000313|EMBL:EMS13512.1};
OS Entamoeba histolytica HM-3:IMSS.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS13512.1, ECO:0000313|Proteomes:UP000030780};
RN [1] {ECO:0000313|EMBL:EMS13512.1, ECO:0000313|Proteomes:UP000030780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS13512.1,
RC ECO:0000313|Proteomes:UP000030780};
RA Inman J., Zafar N., Lorenzi H., Caler E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KB638186; EMS13512.1; -; Genomic_DNA.
DR AlphaFoldDB; M7VZS9; -.
DR EnsemblProtists; EMS13512; EMS13512; KM1_178210.
DR VEuPathDB; AmoebaDB:KM1_178210; -.
DR Proteomes; UP000030780; Unassembled WGS sequence.
DR GO; GO:0016874; F:ligase activity; IEA:UniProtKB-KW.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:InterPro.
DR GO; GO:0000209; P:protein polyubiquitination; IEA:InterPro.
DR CDD; cd00078; HECTc; 1.
DR Gene3D; 3.30.2160.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.30.2410.10; Hect, E3 ligase catalytic domain; 1.
DR Gene3D; 3.90.1750.10; Hect, E3 ligase catalytic domains; 1.
DR Gene3D; 6.10.130.10; Ubiquitin-protein ligase E3A, N-terminal zinc-binding domain (AZUL); 1.
DR InterPro; IPR042556; AZUL_sf.
DR InterPro; IPR044611; E3A/B/C-like.
DR InterPro; IPR000569; HECT_dom.
DR InterPro; IPR035983; Hect_E3_ubiquitin_ligase.
DR PANTHER; PTHR45700:SF8; HECT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45700; UBIQUITIN-PROTEIN LIGASE E3C; 1.
DR Pfam; PF00632; HECT; 1.
DR SMART; SM00119; HECTc; 1.
DR SUPFAM; SSF56204; Hect, E3 ligase catalytic domain; 1.
DR PROSITE; PS50237; HECT; 1.
PE 4: Predicted;
KW Ligase {ECO:0000313|EMBL:EMS13512.1};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|PROSITE-ProRule:PRU00104}.
FT DOMAIN 336..661
FT /note="HECT"
FT /evidence="ECO:0000259|PROSITE:PS50237"
FT ACT_SITE 629
FT /note="Glycyl thioester intermediate"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00104"
SQ SEQUENCE 661 AA; 76353 MW; BC98490BBF3D02B8 CRC64;
METPQITNKK YYINRICFGC GNDQCNNKYC KSSSSFVSPL NIEEEAQQLE INKTPLCTLR
CSLQRFLSLK EEQTSDRLET LLYELYSTPE SIVESFVEEG VFDVVKGWEL IDYILKFQPS
LYQSVLNAHL KILEIVKIKP INIQSIIVTL ASPIFAENDE MGEFCSIIQK LSSFIVELQV
FLRKMTPKQF LCVLGNIEQF ISLRVILKKN TVHDEDILFK VLTLLKTFYS INDDKRFVDE
NKFYNEILAT QRQFPRDIQY FYSNKNTSLL YFPFIIPVDY KMKFLHKEAK QERGQSTVQA
FTESITRGEE QKLNLNIQVR RDHVLEDSLN QLVEANIVDL KKPLKVKFIG EEGLDHGGVS
KEWFQLVTRE IFSPNNTMFV YNDKTRICWF NAGSQQLNDY KLIGTLFGLA IYNGIILDAK
LPIVVYKKIL GINLQMKDLE EIQPEMLHSL EFILKYEGDD MEETMGLTFQ HTQEINGEVK
VIDLKPNGGS IPVTKENKKE FVQLLTDYIL NTSIEKQFNA FISGFKLVFN SRLLTIFSPH
ELELLIAGSD TFDFHELENA TRYANGYTKD TPVVKWLWEI LHSYSIELKK KFLFFSTGSD
RCPPGGLGRL QFIIAKHGDA SRLPTSSTCN NLFLMPPYET KEELEKKLTF ALNNTNGFGL
I
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