ID M7W216_ENTHI Unreviewed; 357 AA.
AC M7W216;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=GPN-loop GTPase {ECO:0000256|RuleBase:RU365059};
DE EC=3.6.5.- {ECO:0000256|RuleBase:RU365059};
GN ORFNames=KM1_206820 {ECO:0000313|EMBL:EMS14272.1};
OS Entamoeba histolytica HM-3:IMSS.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS14272.1, ECO:0000313|Proteomes:UP000030780};
RN [1] {ECO:0000313|EMBL:EMS14272.1, ECO:0000313|Proteomes:UP000030780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS14272.1,
RC ECO:0000313|Proteomes:UP000030780};
RA Inman J., Zafar N., Lorenzi H., Caler E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Small GTPase required for proper nuclear import of RNA
CC polymerase II (RNAPII). May act at an RNAP assembly step prior to
CC nuclear import. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBUNIT: Binds to RNA polymerase II. {ECO:0000256|RuleBase:RU365059}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|RuleBase:RU365059}.
CC Nucleus {ECO:0000256|RuleBase:RU365059}.
CC -!- SIMILARITY: Belongs to the GPN-loop GTPase family.
CC {ECO:0000256|ARBA:ARBA00005290, ECO:0000256|RuleBase:RU365059}.
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DR EMBL; KB637981; EMS14272.1; -; Genomic_DNA.
DR AlphaFoldDB; M7W216; -.
DR EnsemblProtists; EMS14272; EMS14272; KM1_206820.
DR VEuPathDB; AmoebaDB:KM1_206820; -.
DR Proteomes; UP000030780; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd17870; GPN1; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR004130; Gpn.
DR InterPro; IPR030230; Gpn1/Npa3/XAB1.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR21231:SF8; GPN-LOOP GTPASE 1; 1.
DR PANTHER; PTHR21231; XPA-BINDING PROTEIN 1-RELATED; 1.
DR Pfam; PF03029; ATP_bind_1; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|RuleBase:RU365059};
KW GTP-binding {ECO:0000256|RuleBase:RU365059};
KW Hydrolase {ECO:0000256|RuleBase:RU365059};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU365059}.
SQ SEQUENCE 357 AA; 40542 MW; EF5932B91DC09C05 CRC64;
MQDIPLDTKS INVILVGMAG SGKTTLMSIL AEKTDAYLIN LDPACNDPPY SPDIDIRDTV
NYKEVMKDYG LGPNGAIVTS LNLYSTKVDQ LVTVLQNKQQ LTFIDTPGQI EVFTWSASGQ
VISEALSIVA PTIYLYVVDT ARCVENPNTF MANMTYACSI LYKTKLPLII VFTKTDVIPC
TKLNQWMDDY DNYLDALNET ESYASDLQRS LCLALDDFYK NILHCGVSSK TGEGVDKLLE
CIQEGKKQFF EDYYQQVQKK KAEYLKKEQE KKNKQFEQFK KDRQEEDTAR SLVNDDFCGS
AGVTLFKEED EGMIFRNGER FFFGKNVDDD EAIETMNGED IKFHKEIEKD DGVDEFD
//
