ID M7WJ98_ENTHI Unreviewed; 1044 AA.
AC M7WJ98;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 48.
DE SubName: Full=Phosphatidylinositol-4,5-bisphosphate 3-kinase {ECO:0000313|EMBL:EMS17895.1};
GN ORFNames=KM1_148170 {ECO:0000313|EMBL:EMS17895.1};
OS Entamoeba histolytica HM-3:IMSS.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS17895.1, ECO:0000313|Proteomes:UP000030780};
RN [1] {ECO:0000313|EMBL:EMS17895.1, ECO:0000313|Proteomes:UP000030780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS17895.1,
RC ECO:0000313|Proteomes:UP000030780};
RA Inman J., Zafar N., Lorenzi H., Caler E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. {ECO:0000256|PROSITE-
CC ProRule:PRU00880}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KB637079; EMS17895.1; -; Genomic_DNA.
DR AlphaFoldDB; M7WJ98; -.
DR EnsemblProtists; EMS17895; EMS17895; KM1_148170.
DR VEuPathDB; AmoebaDB:KM1_148170; -.
DR Proteomes; UP000030780; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00891; PI3Kc; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR002420; PI3K-type_C2_dom.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR035448; PI3Kc.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF14; LD28067P; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51547; C2_PI3K; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EMS17895.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 328..492
FT /note="C2 PI3K-type"
FT /evidence="ECO:0000259|PROSITE:PS51547"
FT DOMAIN 505..694
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 755..1028
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1044 AA; 119899 MW; 25CE61083DED8C91 CRC64;
MFTYPYYTTP QYSFQPIYST QNQQSIPMYL PQQNNFMYLQ SIPSYQQSYQ QTNYPIQQTY
SINNQTKPNE VVINSDFFQP PQQPLKETNQ LYLNTLFMPS LMESAVDNFA YFEDQSVTKP
FKDHSYTPSI STVCRYVLTP SDKKYAPKYS YSSDELYMRV LVDYSTRLKN KYPYPIQRAI
IKTSSQGEKI CIDRILKIDN DVIHNNFLSF IVSFNKVSYN EVACGAVSIE PNKIKIKVSV
TLTIKDIFRL LEIKDINAVM AIENSSTLFC MDDRLVESEY LCDCITHNRI PEFTIIPFSY
CFYKPLPLNK FGNLVNYSNV ELPVCALIKE PFTFTINSVY YNTHVTDEIH VKCVLRCGDQ
TLSCPMEKVS FKPVVITSPL SPNDEKYIYK FSIDEKVDSN LRICDIPLDC EIILIVFIGQ
KRIGCASVKV FNAWGVLKCG VQLVHLEECK RPIGNGLVSG PIVELNFGST RAAYHIEGVE
DSKLMNIQKE LDTFESVKNR EEFETMIKMD ELKEDEDKVP QLINKMIIDG VDIFQLLRSP
SFITRSPPDY IKRALIEQME NVPAEFIGQI AHSIDWTDHL QVARFVKYLW TQQIKPLDAL
MLLGYRCPYR AVRAYCVSVL DKQPDNVLQF YAIHLSEALR YEEGLTPLTD FLLRRSIASP
ATVGYSLFKM IIGDTSMTKR SIQHSRFIEA LLSADPVFAS QMTKECEFAL NVQTVNSTLI
RMDSEKRQIY RSALLKSISV AVPIPFKPGV IGGLSCEKSK VYTSNAVPLL IDFSGYKMIF
KLGDDLRQDC LILRAFKLFD NLWRMNGMDW RMTTFRVIST GNTAGYIEFV RDSRSIGSIH
NDSKIPGVYK VTAIYDWIKN NKTAPLGQCI ENFYRSCVGY CVASYVLGLA DRHNDNLMVD
KSGHFLHIDF AHFLGNKLKV AGVINREPAP FVLTESMIYV FAGERGTERY KLKYREFCED
CVRAYHVLRQ NASLIVSFFT NMISSQLSQL NEIKDAEYLF TSLQLGKQDS LSDLEFVKLI
HDSLNSEQTN MNFFIHSLVQ KTKK
//
