ID M7WLX7_RHOT1 Unreviewed; 907 AA.
AC M7WLX7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 43.
DE RecName: Full=Chloride channel protein {ECO:0000256|RuleBase:RU361221};
GN ORFNames=RHTO_05428 {ECO:0000313|EMBL:EMS19056.1};
OS Rhodotorula toruloides (strain NP11) (Yeast) (Rhodosporidium toruloides).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX NCBI_TaxID=1130832 {ECO:0000313|EMBL:EMS19056.1, ECO:0000313|Proteomes:UP000016926};
RN [1] {ECO:0000313|EMBL:EMS19056.1, ECO:0000313|Proteomes:UP000016926}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NP11 {ECO:0000313|EMBL:EMS19056.1,
RC ECO:0000313|Proteomes:UP000016926};
RX PubMed=23047670; DOI=10.1038/ncomms2112;
RA Zhu Z., Zhang S., Liu H., Shen H., Lin X., Yang F., Zhou Y.J., Jin G.,
RA Ye M., Zou H., Zou H., Zhao Z.K.;
RT "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.";
RL Nat. Commun. 3:1112-1112(2012).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU361221}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU361221}.
CC -!- SIMILARITY: Belongs to the chloride channel (TC 2.A.49) family.
CC {ECO:0000256|RuleBase:RU361221}.
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DR EMBL; KB722673; EMS19056.1; -; Genomic_DNA.
DR RefSeq; XP_016270175.1; XM_016419090.1.
DR AlphaFoldDB; M7WLX7; -.
DR GeneID; 27369441; -.
DR eggNOG; KOG0475; Eukaryota.
DR HOGENOM; CLU_003181_2_2_1; -.
DR OrthoDB; 150430at2759; -.
DR Proteomes; UP000016926; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0043227; C:membrane-bounded organelle; IEA:UniProt.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:UniProtKB-UniRule.
DR CDD; cd04591; CBS_pair_voltage-gated_CLC_euk_bac; 1.
DR CDD; cd03684; ClC_3_like; 1.
DR Gene3D; 3.10.580.20; -; 1.
DR Gene3D; 3.90.1280.20; -; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 1.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45711:SF9; ANION_PROTON EXCHANGE TRANSPORTER GEF1; 1.
DR PANTHER; PTHR45711; CHLORIDE CHANNEL PROTEIN; 1.
DR Pfam; PF00571; CBS; 2.
DR Pfam; PF00654; Voltage_CLC; 1.
DR PRINTS; PR00762; CLCHANNEL.
DR SMART; SM00116; CBS; 2.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
DR PROSITE; PS51371; CBS; 2.
PE 3: Inferred from homology;
KW CBS domain {ECO:0000256|PROSITE-ProRule:PRU00703};
KW Chloride {ECO:0000256|ARBA:ARBA00023214, ECO:0000256|RuleBase:RU361221};
KW Ion transport {ECO:0000256|RuleBase:RU361221};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361221};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU361221};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU361221}; Transport {ECO:0000256|RuleBase:RU361221}.
FT TRANSMEM 172..196
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 238..259
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 271..291
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 340..364
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 376..393
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 414..433
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 453..474
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 507..526
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 532..553
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 581..604
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT TRANSMEM 610..627
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU361221"
FT DOMAIN 664..723
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT DOMAIN 776..836
FT /note="CBS"
FT /evidence="ECO:0000259|PROSITE:PS51371"
FT REGION 1..69
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 85..109
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 887..907
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 907 AA; 99552 MW; 74B4F13D97E81E1C CRC64;
MDFRSSTDPT PPPDLSTFSL GPSPALQPTL FPSTSSTSHL SSHDARPDPS RLSSTNTPST
PKGRTRRLSS IATVQGTPVI PIERDFGWDT PAIGTGAGGR GSDGRRRLGG ERVRKAVGEE
SRRYEDFTTI DWVADTLLER SRRRYEAATA TRTLGHSLKA GFWRVVEAGQ SWGVVSLVGA
IIGLNAALMS IMTAWLSDLK LGYCTQGWWL NRKFCCWEIE EGFCEDWVTW TGWSGVQWIV
YVLFAGLFAF SCAFLVRSFA PYAAGSGISE IKCILAGFII NGYLSFATLS IKSLTLPIAI
ASGLSVGKEG PSVHVASAIG HVVASRFSRF KRSQAKMREI VTAASATGVA VAFGSPIGGV
LFSLEEMTIN WPIKTMWRSF FCALVANVVL SAMNPFRTGK IVLFQVRFDR DWHFFELGFF
ILIGVFGGLY GAFVIKYNLQ VAAFRRKHLA NNAISEAVTL AILTAAVGFT NRFLRIDMNE
MLDVLFRECE NGGDYENLCQ TWAQWRMVNS LLLATVIRTC LVIVSYGCKV PAGIFVPSMA
VGATFGRMVG ILVKAMYRAH PTWSMFAACD PEKPCITPGT YAFLGAAAGL AGITRITVTV
VVIMFELTGA LTYILPTMIV VMVTKAVSDQ FGGGGIADQM IRFNGYPLLE NHDHAFGVPV
ATVMRKELVC LPSRGMKLDE LQRLLDKTKY QGFPVVNSRK DKTLLGDISR RDLEIAIEKA
QLSHIVAPDA PCLFCPQDDT VSQVGSPSLA NDDGWGTPPD EWDGGEEGVV DFTSFVNQTP
LTVSPKQPLE FVMQLFRRMG PRVILVERFG ELIGLVSVKD CLRYTIAHEA GHDHDTAHSS
NADELEATLE ELRLWWRDVR RWIAEKVTGR TIPPSPEIQL DGAAVFASSS EDAGLSDIDA
RRARDRR
//
