ID   M7WT91_RHOT1            Unreviewed;       418 AA.
AC   M7WT91;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=C-3 sterol dehydrogenase (C-4 sterol decarboxylase) {ECO:0000313|EMBL:EMS21286.1};
GN   ORFNames=RHTO_01752 {ECO:0000313|EMBL:EMS21286.1};
OS   Rhodotorula toruloides (strain NP11) (Yeast) (Rhodosporidium toruloides).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX   NCBI_TaxID=1130832 {ECO:0000313|EMBL:EMS21286.1, ECO:0000313|Proteomes:UP000016926};
RN   [1] {ECO:0000313|EMBL:EMS21286.1, ECO:0000313|Proteomes:UP000016926}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NP11 {ECO:0000313|EMBL:EMS21286.1,
RC   ECO:0000313|Proteomes:UP000016926};
RX   PubMed=23047670; DOI=10.1038/ncomms2112;
RA   Zhu Z., Zhang S., Liu H., Shen H., Lin X., Yang F., Zhou Y.J., Jin G.,
RA   Ye M., Zou H., Zou H., Zhao Z.K.;
RT   "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.";
RL   Nat. Commun. 3:1112-1112(2012).
CC   -!- SIMILARITY: Belongs to the 3-beta-HSD family.
CC       {ECO:0000256|ARBA:ARBA00009219}.
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DR   EMBL; KB722656; EMS21286.1; -; Genomic_DNA.
DR   RefSeq; XP_016272405.1; XM_016415431.1.
DR   AlphaFoldDB; M7WT91; -.
DR   GeneID; 27365765; -.
DR   eggNOG; KOG1430; Eukaryota.
DR   HOGENOM; CLU_007383_6_8_1; -.
DR   OrthoDB; 1133at2759; -.
DR   Proteomes; UP000016926; Unassembled WGS sequence.
DR   GO; GO:0003854; F:3-beta-hydroxy-delta5-steroid dehydrogenase activity; IEA:InterPro.
DR   GO; GO:0006694; P:steroid biosynthetic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   InterPro; IPR002225; 3Beta_OHSteriod_DH/Estase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   PANTHER; PTHR43245; BIFUNCTIONAL POLYMYXIN RESISTANCE PROTEIN ARNA; 1.
DR   PANTHER; PTHR43245:SF51; SHORT CHAIN DEHYDROGENASE_REDUCTASE FAMILY 42E, MEMBER 2; 1.
DR   Pfam; PF01073; 3Beta_HSD; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   3: Inferred from homology;
FT   DOMAIN          13..236
FT                   /note="3-beta hydroxysteroid dehydrogenase/isomerase"
FT                   /evidence="ECO:0000259|Pfam:PF01073"
FT   REGION          256..277
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   418 AA;  46214 MW;  1792EE0B8B1516EB CRC64;
     MSTSPSPSRE SYAVIGGEGF LGAALVSALL GRHPVSRVAS LGLTQRRFDP EGEYRFFRTD
     ITSRESIVEA FRASGATTVF HTASPHANAT PEMWQKVNVQ GTEAVVQACR EAGVRKLVFT
     SSMTAVYRPG VPLTNVDERL PRIETEEKVP SYAGTKAAAE KIVLDANGKD GLLTCAIRLG
     GIIGPGDRQV LPGFIGVWKD GQSAFQMGDN RNMLDFVTVK NAVHAHLLAA DKLDAPPLSP
     DDFEVRIKPV ACTVPRRNLP TSEQPDASAA KPDPPLPASR NRWNQFFPLT DDPSSAPSLS
     VAGQAFFITN GEPVSFWSFA RAVYFAYSRR PPRWFEPVVL PSSVGMLYAT LCEWAGWCVG
     KRPEECAVNR AYMQYVLHDL YMDIERARRL LGYEPIESLE EGIRTGVEWY KMDERRRE
//