ID   M7WYP4_ENTHI            Unreviewed;       641 AA.
AC   M7WYP4;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   27-MAR-2024, entry version 34.
DE   SubName: Full=Rho guanine nucleotide exchange factor, putative {ECO:0000313|EMBL:EMS16524.1};
GN   ORFNames=KM1_078440 {ECO:0000313|EMBL:EMS16524.1};
OS   Entamoeba histolytica HM-3:IMSS.
OC   Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC   Entamoeba.
OX   NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS16524.1, ECO:0000313|Proteomes:UP000030780};
RN   [1] {ECO:0000313|EMBL:EMS16524.1, ECO:0000313|Proteomes:UP000030780}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS16524.1,
RC   ECO:0000313|Proteomes:UP000030780};
RA   Inman J., Zafar N., Lorenzi H., Caler E.;
RL   Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
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DR   EMBL; KB637399; EMS16524.1; -; Genomic_DNA.
DR   EnsemblProtists; EMS16524; EMS16524; KM1_078440.
DR   VEuPathDB; AmoebaDB:KM1_078440; -.
DR   Proteomes; UP000030780; Unassembled WGS sequence.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR   CDD; cd00065; FYVE_like_SF; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR001331; GDS_CDC24_CS.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR   PANTHER; PTHR12673:SF159; RAC GUANINE NUCLEOTIDE EXCHANGE FACTOR JJ; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR   PROSITE; PS00741; DH_1; 1.
DR   PROSITE; PS50010; DH_2; 1.
PE   4: Predicted;
FT   DOMAIN          5..192
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
SQ   SEQUENCE   641 AA;  73160 MW;  E3312146FA28D813 CRC64;
     MELSKRQRIL DEIYNTEVSY LNFLKICQTV YFEDMISHVP PIIPLEKTNE MFKYLDTIIT
     ISQELIRLFD ESKKSNCFES EIGNIFIQMQ SYLKGYNLYV ANNAYALNIA DRLYKKEKYA
     KYLETLRQSI QGPDTMKLDL NSFLIMPVQR VPRYRLLLQD LLKNTPDGTL GKSALATALE
     QIKVLGISIN ESIADEERRR KLLEIQSRLP KSLQPKFVCP GREFVMETTV VLTWEEKLTK
     LTLIFVTDML IFAETVNKRI DVKYVMIIGR IKRQTGERTE FELYTKEDGN IKLVFLNEKD
     GQLFHDKITE LIPVQVKKLA EKKAAEDECP CCRKSLNRLA SYSSPGFIVC AKCNKKVCNT
     CATTKIALVA GGAPRKVCDA CILEQFTKQQ ETNKKLKQKK EPLLLNSQKK DINEFQQNLI
     TSSCTSSQVF TSPMLCSTGH NIYSTPMMTS NPYYIPLTYS TRQIPQTFTT SQPLSQTFTT
     SQPLSQTFTT SQPLSQTFTT XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
     XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXTFTTS QPLSQTFTTS QPLSQTFTTS
     QPLSQTVNCS NQTQRSQIEI LKNLNVPQRR PQTKLNKKNL N
//