ID M7X0W6_ENTHI Unreviewed; 423 AA.
AC M7X0W6;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 39.
DE RecName: Full=Phosphotransferase {ECO:0000256|RuleBase:RU362007};
DE EC=2.7.1.- {ECO:0000256|RuleBase:RU362007};
GN ORFNames=KM1_095060 {ECO:0000313|EMBL:EMS13623.1};
OS Entamoeba histolytica HM-3:IMSS.
OC Eukaryota; Amoebozoa; Evosea; Archamoebae; Mastigamoebida; Entamoebidae;
OC Entamoeba.
OX NCBI_TaxID=885315 {ECO:0000313|EMBL:EMS13623.1, ECO:0000313|Proteomes:UP000030780};
RN [1] {ECO:0000313|EMBL:EMS13623.1, ECO:0000313|Proteomes:UP000030780}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=HM-3:IMSS {ECO:0000313|EMBL:EMS13623.1,
RC ECO:0000313|Proteomes:UP000030780};
RA Inman J., Zafar N., Lorenzi H., Caler E.;
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + D-fructose = ADP + D-fructose 6-phosphate + H(+);
CC Xref=Rhea:RHEA:16125, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:37721, ChEBI:CHEBI:61527, ChEBI:CHEBI:456216; EC=2.7.1.1;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16126;
CC Evidence={ECO:0000256|ARBA:ARBA00001397};
CC -!- PATHWAY: Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-
CC phosphate and glycerone phosphate from D-glucose: step 1/4.
CC {ECO:0000256|ARBA:ARBA00004888}.
CC -!- PATHWAY: Carbohydrate metabolism; hexose metabolism.
CC {ECO:0000256|ARBA:ARBA00005028}.
CC -!- SIMILARITY: Belongs to the hexokinase family.
CC {ECO:0000256|ARBA:ARBA00009225, ECO:0000256|RuleBase:RU362007}.
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DR EMBL; KB638151; EMS13623.1; -; Genomic_DNA.
DR EnsemblProtists; EMS13623; EMS13623; KM1_095060.
DR VEuPathDB; AmoebaDB:KM1_095060; -.
DR UniPathway; UPA00109; UER00180.
DR Proteomes; UP000030780; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0008865; F:fructokinase activity; IEA:RHEA.
DR GO; GO:0005536; F:glucose binding; IEA:InterPro.
DR GO; GO:0006096; P:glycolytic process; IEA:UniProtKB-UniPathway.
DR GO; GO:0001678; P:intracellular glucose homeostasis; IEA:InterPro.
DR CDD; cd00012; NBD_sugar-kinase_HSP70_actin; 1.
DR Gene3D; 3.30.420.40; -; 2.
DR Gene3D; 3.40.367.20; -; 2.
DR InterPro; IPR043129; ATPase_NBD.
DR InterPro; IPR001312; Hexokinase.
DR InterPro; IPR022673; Hexokinase_C.
DR InterPro; IPR022672; Hexokinase_N.
DR PANTHER; PTHR19443; HEXOKINASE; 1.
DR PANTHER; PTHR19443:SF16; HEXOKINASE TYPE 1-RELATED; 1.
DR Pfam; PF00349; Hexokinase_1; 1.
DR Pfam; PF03727; Hexokinase_2; 1.
DR PRINTS; PR00475; HEXOKINASE.
DR SUPFAM; SSF53067; Actin-like ATPase domain; 2.
DR PROSITE; PS51748; HEXOKINASE_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU362007};
KW Glycolysis {ECO:0000256|RuleBase:RU362007};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000256|RuleBase:RU362007};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU362007};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU362007}.
FT DOMAIN 2..136
FT /note="Hexokinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00349"
FT DOMAIN 143..417
FT /note="Hexokinase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03727"
SQ SEQUENCE 423 AA; 47086 MW; F0B19D8C89EE5212 CRC64;
MGIDVGGTNL RVLLLEIPEP GVRGELKSVE CIMPKTSTTV DQFFGFIAQK IKEFVENNNL
KEKEIKAGLT FSFAVEQIAI DKGIQQSWSK GWDVKESIGK DIVEIFHNQL AKINVNNIRI
VAFINDTVGT FANLAYDDAS CGMGLIFGTG TNGCYIEKTS NFAASKLKSV YKEDYMIVNT
EWGGLQFPEL GLNRFDDMIN DVSXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXXXXXX
XXXXXXXISG IYMGWLARLA IRELIEKKVI FERYADAEVF SNSPDDTQFN DKKKYSSRHT
EIVEDTSPEL SRVDTILKSL GVNDSTLEER KILKAITEAV VKRAAYLSAA ATVALYRKMV
PYMKERTTAG IDGTVYEKSV PFKRFYLEAI RLLQPKENFT CQLSKDGSGL GAVIVAAAVA
CKH
//
