UniProt: M7X534

Database: UniProt
Entry: M7X534_RHOT1

LinkDB:  M7X534_RHOT1 
Original site:  M7X534_RHOT1

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Ontology (2)   
   GO (2)   
Gene (1)   
   NCBI-Gene (1)   
Protein sequence (1)   
   RefSeq(pep) (1)   
DNA sequence (1)   
   EMBL (1)   
Protein domain (3)   
   InterPro (2)   
   Pfam (1)   
Literature (1)   
   PubMed (1)   
All databases (9)   

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ID   M7X534_RHOT1            Unreviewed;       859 AA.
AC   M7X534;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 29.
DE   RecName: Full=V-type proton ATPase subunit a {ECO:0000256|RuleBase:RU361189};
GN   ORFNames=RHTO_02933 {ECO:0000313|EMBL:EMS25205.1};
OS   Rhodotorula toruloides (strain NP11) (Yeast) (Rhodosporidium toruloides).
OC   Eukaryota; Fungi; Dikarya; Basidiomycota; Pucciniomycotina;
OC   Microbotryomycetes; Sporidiobolales; Sporidiobolaceae; Rhodotorula.
OX   NCBI_TaxID=1130832 {ECO:0000313|EMBL:EMS25205.1, ECO:0000313|Proteomes:UP000016926};
RN   [1] {ECO:0000313|EMBL:EMS25205.1, ECO:0000313|Proteomes:UP000016926}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=NP11 {ECO:0000313|EMBL:EMS25205.1,
RC   ECO:0000313|Proteomes:UP000016926};
RX   PubMed=23047670; DOI=10.1038/ncomms2112;
RA   Zhu Z., Zhang S., Liu H., Shen H., Lin X., Yang F., Zhou Y.J., Jin G.,
RA   Ye M., Zou H., Zou H., Zhao Z.K.;
RT   "A multi-omic map of the lipid-producing yeast Rhodosporidium toruloides.";
RL   Nat. Commun. 3:1112-1112(2012).
CC   -!- FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a
CC       multimeric enzyme that catalyzes the translocation of protons across
CC       the membranes. Required for assembly and activity of the V-ATPase.
CC       {ECO:0000256|RuleBase:RU361189}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the V-ATPase 116 kDa subunit family.
CC       {ECO:0000256|ARBA:ARBA00009904, ECO:0000256|RuleBase:RU361189}.
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DR   EMBL; KB722643; EMS25205.1; -; Genomic_DNA.
DR   RefSeq; XP_016276324.1; XM_016416605.1.
DR   AlphaFoldDB; M7X534; -.
DR   GeneID; 27366946; -.
DR   eggNOG; KOG2189; Eukaryota.
DR   HOGENOM; CLU_005230_0_0_1; -.
DR   OrthoDB; 1967517at2759; -.
DR   Proteomes; UP000016926; Unassembled WGS sequence.
DR   GO; GO:0000220; C:vacuolar proton-transporting V-type ATPase, V0 domain; IEA:InterPro.
DR   GO; GO:0046961; F:proton-transporting ATPase activity, rotational mechanism; IEA:InterPro.
DR   InterPro; IPR002490; V-ATPase_116kDa_su.
DR   InterPro; IPR026028; V-type_ATPase_116kDa_su_euka.
DR   PANTHER; PTHR11629:SF63; V-TYPE PROTON ATPASE SUBUNIT A; 1.
DR   PANTHER; PTHR11629; VACUOLAR PROTON ATPASES; 1.
DR   Pfam; PF01496; V_ATPase_I; 1.
DR   PIRSF; PIRSF001293; ATP6V0A1; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Hydrogen ion transport {ECO:0000256|ARBA:ARBA00022781,
KW   ECO:0000256|RuleBase:RU361189};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW   ECO:0000256|RuleBase:RU361189};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU361189};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU361189};
KW   Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU361189}.
FT   TRANSMEM        436..459
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        480..499
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        562..581
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        593..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        654..673
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   TRANSMEM        790..814
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU361189"
FT   REGION          696..715
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          104..138
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   859 AA;  96216 MW;  AA7B674C96FAA3C8 CRC64;
     MGDYEVTQYP SLLRSEHMTL VQLFCPIDVA HATVEALGEL ERIQFKDLNP DVNPFQRTYA
     ERRLRFLTQQ IASQGIHIRP ASETLALLSG RSGPQALDDL DTRLSESESR VQAMNTSFEN
     LEKRALELEE ARQVLRDTER FFLEAQGGRG APGDYRASFE QGEMEAPLLG DVEHAGPAGG
     AGDAAAGGFE LEFVAGTIDR SRMATFERVL WRVLRGNLYM NSAEIADDVL PVPSTMQGTS
     DSAGGEEKRL RKNAFVIFAH GQDLLDKIRK IAESMGATLF AIDSSSDKRS DKLREVTSRI
     EDLHSVLYNT NQTRRAELLK IADSISAWWA LVRKEKVVFA TLNMWQWDQG RKTLVAEGWV
     PTRDIPQVQA ALRRASENAG TSVSALLHEL RTTKTPPTFH RTNKFTEGFQ NIIDAYGIGS
     YQEVNPGLFT VITFPFLFAV MFGDIGHGAL MMLSALVLIM LEKKFGKKGM GSEILDTFYF
     GRYIIFLMGA FAIYTGIMYN DIFSLSLRLG PSQWHWPDEG SAGKAVEAIQ TSSRYWIGLD
     PGWHGAENAL IFTNSLKMKM SIVLGVLHMS FAICLQVLNH LHFNRPELIW AEFLPQILFM
     ESIFGYLVVC IVYKWSVDWE AAGRNPPNLL NMLIQMFLSP GNVNPDDQLY RGQAFVQVFL
     LLLALVCVPW MLCTRPYLEY REMHKIKEQG YHGIQNGENG AHATDDETDT DGEGAHQGHA
     VAMTEEAEEE GHDLGEVIIH QVIHTIEFCL GCISNTASYL RLWALSLAHA QLSEVLWNMT
     IENAFGFEGV LAVVMLVFLF AMWFVLTIAI LCVMEGLSAF LHALRLHWVE FNSKFFIGAG
     TAFDPLTFEG TDEIPEGVI
//

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