ID M7XR02_9BACT Unreviewed; 741 AA.
AC M7XR02;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=GTP pyrophosphokinase {ECO:0000313|EMBL:EMS30987.1};
GN ORFNames=C943_02775 {ECO:0000313|EMBL:EMS30987.1};
OS Mariniradius saccharolyticus AK6.
OC Bacteria; Bacteroidota; Cytophagia; Cytophagales; Cyclobacteriaceae;
OC Mariniradius.
OX NCBI_TaxID=1239962 {ECO:0000313|EMBL:EMS30987.1, ECO:0000313|Proteomes:UP000010953};
RN [1] {ECO:0000313|EMBL:EMS30987.1, ECO:0000313|Proteomes:UP000010953}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AK6 {ECO:0000313|EMBL:EMS30987.1,
RC ECO:0000313|Proteomes:UP000010953};
RA Vaidya B., Khatri I., Tanuku N.R.S., Subramanian S., Pinnaka A.;
RT "Genome assembly of Mariniradius saccharolyticus AK6.";
RL Submitted (JAN-2013) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate)
CC is a mediator of the stringent response that coordinates a variety of
CC cellular activities in response to changes in nutritional abundance.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- SIMILARITY: Belongs to the relA/spoT family.
CC {ECO:0000256|RuleBase:RU003847}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:EMS30987.1}.
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DR EMBL; AMZY02000026; EMS30987.1; -; Genomic_DNA.
DR RefSeq; WP_008631881.1; NZ_AMZY02000026.1.
DR AlphaFoldDB; M7XR02; -.
DR STRING; 1239962.C943_02775; -.
DR eggNOG; COG0317; Bacteria.
DR InParanoid; M7XR02; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000010953; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd04876; ACT_RelA-SpoT; 1.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR CDD; cd01668; TGS_RSH; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR004811; RelA/Spo_fam.
DR InterPro; IPR045600; RelA/SpoT_AH_RIS.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR InterPro; IPR033655; TGS_RelA/SpoT.
DR NCBIfam; TIGR00691; spoT_relA; 1.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF19296; RelA_AH_RIS; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000313|EMBL:EMS30987.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000010953};
KW Transferase {ECO:0000313|EMBL:EMS30987.1}.
FT DOMAIN 406..467
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
SQ SEQUENCE 741 AA; 84952 MW; A9BC63962B138A88 CRC64;
MIQIDLEEER KEILKRYRKL LKMAKPLLKE GDARIIKKAF SISNDAHKEM RRKSGEPYIY
HPLEVAMICV EEIGLGTTSI VAALLHDVVE DTDWELEDIE REFGHKVATI IDGLTKISGV
FEYGSSQQAE NFRKMLLTLS DDVRVILIKL ADRLNNMRTL DSMPRHKQLK IASETMYLYA
PLAHRLGLYA IKSELEDLYL KFTDSETYRF IANKINETRI SRNRFIKTFI APIEEELESQ
GFRFTIKGRP KSVFSIYNKM KKQNIPFEEV YDLFAIRIII DSEIDNEKAD CWQVYSIVTD
FYRPNPDRLR DWISTPRANG YESLHTTVMS NTGQWVEVQI RTVRMDDIAE RGYAAHWKYK
EKDAAQGGKG PSGLDEWITQ VRSLLESNDG NAIEFMDDFR GNLFHDEVFV FTPKGELKVL
PHGATALDFA FEIHTEVGAK CIGAKVNTRL VPINHKLKNG DQVEILTSAK QRPTEDWLNS
VVTSRAKAKI KDALKEEKRS TILDGKEIVQ RKLKQMKMDF NSEIVEQLRA YFETKTPNEF
YYKIGKGIID PTSIKSFKDF KEQKRQKSKP SLDKVKDESS FTKEIKNLKG PEHDQLLIGE
DMDVVDYILA KCCNPIPGDD VFGFVTVNEG IKIHRTSCPN ALELLSNHGN RVIKARWTSQ
QQIAFLAGLR IVGTDRVGLI NDVTKVISNE LKVNMRSITV DSDSGIFEGT IKLYVHSTQH
LEKLMSNLSK VEGIIKVARF D
//
