ID M7YQH0_TRIUA Unreviewed; 900 AA.
AC M7YQH0;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=RBR-type E3 ubiquitin transferase {ECO:0000256|ARBA:ARBA00012251};
DE EC=2.3.2.31 {ECO:0000256|ARBA:ARBA00012251};
GN ORFNames=TRIUR3_20601 {ECO:0000313|EMBL:EMS49256.1};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS49256.1};
RN [1] {ECO:0000313|EMBL:EMS49256.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
CC -!- FUNCTION: Might act as an E3 ubiquitin-protein ligase, or as part of E3
CC complex, which accepts ubiquitin from specific E2 ubiquitin-conjugating
CC enzymes and then transfers it to substrates.
CC {ECO:0000256|ARBA:ARBA00003976}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=[E2 ubiquitin-conjugating enzyme]-S-ubiquitinyl-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + [acceptor protein]-N(6)-ubiquitinyl-L-lysine.;
CC EC=2.3.2.31; Evidence={ECO:0000256|ARBA:ARBA00001798};
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the RBR family. Ariadne subfamily.
CC {ECO:0000256|ARBA:ARBA00005884}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KD244972; EMS49256.1; -; Genomic_DNA.
DR AlphaFoldDB; M7YQH0; -.
DR STRING; 4572.M7YQH0; -.
DR eggNOG; KOG1815; Eukaryota.
DR GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR GO; GO:0004523; F:RNA-DNA hybrid ribonuclease activity; IEA:InterPro.
DR GO; GO:0004842; F:ubiquitin-protein transferase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0016567; P:protein ubiquitination; IEA:InterPro.
DR CDD; cd20346; BRcat_RBR_ANKIB1; 1.
DR CDD; cd23141; RING-HC_ARI6-like; 1.
DR CDD; cd06222; RNase_H_like; 1.
DR Gene3D; 1.20.120.1750; -; 1.
DR Gene3D; 3.30.420.10; Ribonuclease H-like superfamily/Ribonuclease H; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR045840; Ariadne.
DR InterPro; IPR048962; ARIH1-like_UBL.
DR InterPro; IPR031127; E3_UB_ligase_RBR.
DR InterPro; IPR002867; IBR_dom.
DR InterPro; IPR044730; RNase_H-like_dom_plant.
DR InterPro; IPR012337; RNaseH-like_sf.
DR InterPro; IPR002156; RNaseH_domain.
DR InterPro; IPR036397; RNaseH_sf.
DR InterPro; IPR044066; TRIAD_supradom.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR11685; RBR FAMILY RING FINGER AND IBR DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR11685:SF477; RBR-TYPE E3 UBIQUITIN TRANSFERASE; 1.
DR Pfam; PF21235; ARI1_UBAl; 1.
DR Pfam; PF19422; Ariadne; 1.
DR Pfam; PF01485; IBR; 1.
DR Pfam; PF13456; RVT_3; 1.
DR SMART; SM00647; IBR; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR SUPFAM; SSF57850; RING/U-box; 2.
DR PROSITE; PS51873; TRIAD; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
SQ SEQUENCE 900 AA; 100842 MW; 34DDA9D62D483D88 CRC64;
MGSWSTPSSP EHMAKQDNGA LSGQPDGRRS VWNLIWKNGA PAKAKENVHH ALVICPHAAT
LWEAMQEHWA LLTPADLRDT EPDWLLRLLD KLPDVQKLAS LMIMWRICPD QGLASVPIEL
YQFPTCNTAA PEVDLTKGKQ VIDYSGSTSK TTHEILATPQ WKPPDVNYAK PNVHGAFLKE
DGTTGAGMIL RDHEGTIIFA AKRVLFNCGG PLEAEMAAMD EGLRLALYWS SLPLVVETDY
AELLKMMQSK DIERSRYANQ INESRYGANT IQKDKIQRKW MSDWCLVGVG RCGVAKRLRR
ARRRPVAAMD SEDDTRDSAD EDFYSGGEAG LALSDDGDAD YDFADRDSDD SDDLISHRQQ
QNYSVLSETD IKQHQADDMN RVSTVLSISK SEACALLRSY NWSVSKVHDE WFVDEARVRT
AVGLPEKQNE MPNERELTCG ICFESCPRES MGAASCGHPF CGVCWRGYIS TAINDGPGCL
MLRCPDPSCS AAVGQDMVNL FASDEDKGKY ERYLCRSYIE DNRKTKWCPA PGCEYAVEFV
VGSGSYDVSC GCSYGFCWNC TEEAHRPVDC STVSKWILKN SAESENMNWL CLGPWSDHGE
RTGGFYACNR YEAARQEGAF DDSERRREMA KNSLERYTHY YERWAANQSS RQKALGDLQS
LQNDKLEKLS DIQSQPESQL KFIIEAWLQI VECRRVLKWT YAYGYYLPDH EHAKRQFFEY
VQGEAESGLE RLHQCAEKEL QIYLDADCPS KDFNDFRTKL AGLTSVTRNY FENLVRALES
GLNDVGAHSG QGACSKAVSS KNLGGKSKSG KNKAPVGASK SGSSTRGMDD GNIWACDQCT
FANPRSARSC QEQQYRYSKI KCTLVCSSDF VYESLVDCND KAFVRCGVCF APMAELKDPV
//
