ID M8ACJ7_TRIUA Unreviewed; 898 AA.
AC M8ACJ7;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 67.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
DE AltName: Full=Minichromosome maintenance 8 {ECO:0000256|ARBA:ARBA00042306};
GN ORFNames=TRIUR3_25923 {ECO:0000313|EMBL:EMS58294.1};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS58294.1};
RN [1] {ECO:0000313|EMBL:EMS58294.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the MCM family. {ECO:0000256|RuleBase:RU004070}.
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DR EMBL; KD134980; EMS58294.1; -; Genomic_DNA.
DR AlphaFoldDB; M8ACJ7; -.
DR STRING; 4572.M8ACJ7; -.
DR eggNOG; KOG0480; Eukaryota.
DR OMA; VVWPRYF; -.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0032508; P:DNA duplex unwinding; IEA:InterPro.
DR GO; GO:0000724; P:double-strand break repair via homologous recombination; IEA:EnsemblPlants.
DR GO; GO:0007143; P:female meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0007140; P:male meiotic nuclear division; IEA:EnsemblPlants.
DR GO; GO:0009555; P:pollen development; IEA:EnsemblPlants.
DR CDD; cd17759; MCM8; 1.
DR CDD; cd22247; MCM8_WHD; 1.
DR Gene3D; 2.40.50.140; Nucleic acid-binding proteins; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR031327; MCM.
DR InterPro; IPR001208; MCM_dom.
DR InterPro; IPR041562; MCM_lid.
DR InterPro; IPR033762; MCM_OB.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11630:SF47; DNA HELICASE MCM8; 1.
DR PANTHER; PTHR11630; DNA REPLICATION LICENSING FACTOR MCM FAMILY MEMBER; 1.
DR Pfam; PF00493; MCM; 1.
DR Pfam; PF17855; MCM_lid; 1.
DR Pfam; PF17207; MCM_OB; 1.
DR PRINTS; PR01657; MCMFAMILY.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00350; MCM; 1.
DR SUPFAM; SSF50249; Nucleic acid-binding proteins; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50051; MCM_2; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|RuleBase:RU004070};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU004070};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004070}; Nucleus {ECO:0000256|ARBA:ARBA00023242}.
SQ SEQUENCE 898 AA; 99478 MW; 20510D6978A850AF CRC64;
MPLSYMYETF PKLLQPVGSV SDEVLEATRA NRWHERAERI LDDVMAWSQS VKEWKKVKAE
MEADAKYNFF NNKIQVVQKI HYDETLPPGS VAKWQLMSGR VAHPITRVTG SRTAFPTVVG
SGGSMSARMY ADTQKGRPGC RPVDASRGAD LAVVWPRYFP EETEHPVPAG DPRARLVGDL
VKVMGLEERA KLLPRVEDDG VVFFLPIDFQ QLKNLCGGTN LLDALRENPK EALLCMGVAV
HLAKCSGNGL QLSDVDKVNI RLYNHTETII ALKNLKAAYI KKLATVRGTV VKVSTVKPLV
LALEFQCTKI QELSSAENRE EGRVPRTIEC ELTEDLVDCC IPGEVVTVAG IVKVLNNYMD
VGGGKSKSRN QGLYYLYLEA ISVRNSKAHV VSENSDASST DILATGSFSF ETFTDKDLKF
ITEYNSEHGA DVFRQILHSF CPSIYGHELV KAGITLALFG AVQKHSMDQN KVPIRGDIHV
IIVGDPGLGK SQLLKAAASV SPRGIYVCGN TTTNAGLTVA VVKDSMTNDY AFEAGAMVLA
DRGLCCIDEF DKMSAEYQSL LEAMEQQCVS VAKAGLVASL SARTSVLAAA NPVGGHYDRG
KTVNENLKMN AALLSRFDLV FILLDQPDLF LDKRVSDHIM ALHTNDRSPC SSNKRLRTVP
QFNGSMGIGI DEKKLASRLR LHPEKDRDFV PLPEPLLRKY ISYARSYVTP RMSEPAAVVL
RKYYLNLRAH STCSDGTPIT ARQLESLVRL AEARARVDLR EEVTEQDAND VVEIMNESLY
DKYVDEHGCV DYARSGGMSQ QKEAKRLMSA LNKQSELQQK DHFSRAEIRS LADKISLQVP
DLDDIMEKLN SADIDLIMFT DPANKIKMVS SLTPYMKTWE FGVGIMLNLI SVPHVNVD
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