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Database: UniProt
Entry: M8AR98_TRIUA
LinkDB: M8AR98_TRIUA
Original site: M8AR98_TRIUA 
ID   M8AR98_TRIUA            Unreviewed;      1193 AA.
AC   M8AR98;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   24-JAN-2024, entry version 65.
DE   RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE            EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN   ORFNames=TRIUR3_24832 {ECO:0000313|EMBL:EMS63514.1};
OS   Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC   Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX   NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS63514.1};
RN   [1] {ECO:0000313|EMBL:EMS63514.1}
RP   NUCLEOTIDE SEQUENCE.
RX   PubMed=23535596; DOI=10.1038/nature11997;
RA   Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA   Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA   Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA   Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA   Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA   Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA   Wang D., Zhang A., Wang J.;
RT   "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL   Nature 496:87-90(2013).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC         1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC         H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC         EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR   EMBL; KD068030; EMS63514.1; -; Genomic_DNA.
DR   AlphaFoldDB; M8AR98; -.
DR   STRING; 4572.M8AR98; -.
DR   eggNOG; KOG0903; Eukaryota.
DR   OMA; AYPLWTV; -.
DR   GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR   GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR   GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR   CDD; cd05168; PI4Kc_III_beta; 1.
DR   Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR   Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR011009; Kinase-like_dom_sf.
DR   InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR   InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR   InterPro; IPR018936; PI3/4_kinase_CS.
DR   InterPro; IPR001263; PI3K_accessory_dom.
DR   InterPro; IPR042236; PI3K_accessory_sf.
DR   InterPro; IPR049160; PI4KB-PIK1_PIK.
DR   InterPro; IPR015433; PI_Kinase.
DR   PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR   PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR   Pfam; PF00454; PI3_PI4_kinase; 1.
DR   Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR   SMART; SM00146; PI3Kc; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR   PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR   PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR   PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR   PROSITE; PS51545; PIK_HELICAL; 1.
PE   4: Predicted;
KW   Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EMS63514.1};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT   DOMAIN          1..145
FT                   /note="PIK helical"
FT                   /evidence="ECO:0000259|PROSITE:PS51545"
FT   DOMAIN          926..1178
FT                   /note="PI3K/PI4K catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50290"
SQ   SEQUENCE   1193 AA;  134963 MW;  C53F3512ED605E2C CRC64;
     MVRLLGLRGL SFGPEESPRE ITAAGGDAAP PVGSSGWLVR FFDSAFFCEW IAVSYLYKHD
     HAGVRDYLCN RMYTLPLSGL EAYLFQVCYM LVHKPSPSLD RFVIDTCAKS LRIALKVHWI
     LAAELELEET EDLDGIDKVQ EQCQAAATVQ GEWPPLVRPA PLSPVASPRG NPMLSRIRSS
     KQRLMSLASS PSLGLSPPPS STNVSAAEDA GVGKGKQPVT PSSEDNKLLR RLSIGPKAFF
     RRSVEKDEEQ DKDGFFKRLL RDSKDKEEDD GDKEGFFKRL LKDSKEKEND EEEGDKDGLF
     RRLLRDSKDE DMELTPSSDG LLKRLFRDKE DSKGDDDEKE GFFRRIFKDK NEERRESMHG
     RLGDEERVGK SLEDDDREGF FRKIFKDKNE EKKDGGSHKQ NDDREKVGVN IEEDKKDGFF
     RQLFKEKNDE KKEGTTPSRK EDDSRGNKSI DDDNFFRRIF KDKNEEKKGV AHDRNEGEKC
     EEGDKENFFR KLFKDKDKHE DRRIEGLDKN DDDGKSTSGI EEEENSEFLS FRRLFRVHPE
     DTKSGHIEGS QPNGISEGSP GSESFFKRLF RDREDSEILG SKLLKEARHL LLIFLSRHPD
     PTGNSEKQSG KPPLPNNVLA ELRKGSYYAS LELVQSLCDT SYGLVDIFPV EDRKIALRES
     LTEINSHIAS SEKNGGVCFP MGRGIYRVVH IPEDESVLLN SREKAPYLIC VEVLKAETPS
     HSKGSSDVNK LSKGGIPLAN GDVQLPKPPP WAYPLWSRHE PQNYETDRML NSTSQVIDQA
     MAQLWEAKVK FVNVSFSIER IGRSRSIAMS ESGRRIRQPT AESHNLSEDS QAVVDQPIEW
     VKVTLSAVPG VNMEDVDDNE PTRKKDHRRV PSTIAMEEVK AAALKGEAPP GLPLKGVGQS
     TQNLDPKATD GGDPKPTDAL AGELWTVKKE RIRRSSVHGK LPGWDLRSII VKSGDDCRQE
     HLAVQLVAHF YDIYQEAGLP LWLRPYEVIV TSAYAALIET IPDTASIHSI KSRFPNILSL
     RDYYVAKYEE NSPNFKLAQR NFVESMAGYS ILSYLLQVKD RHNGNLLIDE EGHIIHIDFG
     FMLSNSPGGV MDSDAEGTPS EFFDYFKVLC IQGFLTCRKH AERVILLVEM LQDSGFPCFK
     GGTRTILNLR KRFHLSLTEE QCVSLVLSLI SSSMDAWRTR QYDYYQRVLN GIL
//
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