ID M8AR98_TRIUA Unreviewed; 1193 AA.
AC M8AR98;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 24-JAN-2024, entry version 65.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN ORFNames=TRIUR3_24832 {ECO:0000313|EMBL:EMS63514.1};
OS Triticum urartu (Red wild einkorn) (Crithodium urartu).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; Liliopsida; Poales; Poaceae; BOP clade;
OC Pooideae; Triticodae; Triticeae; Triticinae; Triticum.
OX NCBI_TaxID=4572 {ECO:0000313|EMBL:EMS63514.1};
RN [1] {ECO:0000313|EMBL:EMS63514.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=23535596; DOI=10.1038/nature11997;
RA Ling H.Q., Zhao S., Liu D., Wang J., Sun H., Zhang C., Fan H., Li D.,
RA Dong L., Tao Y., Gao C., Wu H., Li Y., Cui Y., Guo X., Zheng S., Wang B.,
RA Yu K., Liang Q., Yang W., Lou X., Chen J., Feng M., Jian J., Zhang X.,
RA Luo G., Jiang Y., Liu J., Wang Z., Sha Y., Zhang B., Wu H., Tang D.,
RA Shen Q., Xue P., Zou S., Wang X., Liu X., Wang F., Yang Y., An X., Dong Z.,
RA Zhang K., Zhang X., Luo M.C., Dvorak J., Tong Y., Wang J., Yang H., Li Z.,
RA Wang D., Zhang A., Wang J.;
RT "Draft genome of the wheat A-genome progenitor Triticum urartu.";
RL Nature 496:87-90(2013).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol) + ATP = a
CC 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate) + ADP +
CC H(+); Xref=Rhea:RHEA:19877, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:57880, ChEBI:CHEBI:58178, ChEBI:CHEBI:456216;
CC EC=2.7.1.67; Evidence={ECO:0000256|ARBA:ARBA00001686};
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DR EMBL; KD068030; EMS63514.1; -; Genomic_DNA.
DR AlphaFoldDB; M8AR98; -.
DR STRING; 4572.M8AR98; -.
DR eggNOG; KOG0903; Eukaryota.
DR OMA; AYPLWTV; -.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0048015; P:phosphatidylinositol-mediated signaling; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd05168; PI4Kc_III_beta; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR049160; PI4KB-PIK1_PIK.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF22; PHOSPHATIDYLINOSITOL 4-KINASE BETA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF21245; PI4KB-PIK1_PIK; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 4: Predicted;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:EMS63514.1};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..145
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 926..1178
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1193 AA; 134963 MW; C53F3512ED605E2C CRC64;
MVRLLGLRGL SFGPEESPRE ITAAGGDAAP PVGSSGWLVR FFDSAFFCEW IAVSYLYKHD
HAGVRDYLCN RMYTLPLSGL EAYLFQVCYM LVHKPSPSLD RFVIDTCAKS LRIALKVHWI
LAAELELEET EDLDGIDKVQ EQCQAAATVQ GEWPPLVRPA PLSPVASPRG NPMLSRIRSS
KQRLMSLASS PSLGLSPPPS STNVSAAEDA GVGKGKQPVT PSSEDNKLLR RLSIGPKAFF
RRSVEKDEEQ DKDGFFKRLL RDSKDKEEDD GDKEGFFKRL LKDSKEKEND EEEGDKDGLF
RRLLRDSKDE DMELTPSSDG LLKRLFRDKE DSKGDDDEKE GFFRRIFKDK NEERRESMHG
RLGDEERVGK SLEDDDREGF FRKIFKDKNE EKKDGGSHKQ NDDREKVGVN IEEDKKDGFF
RQLFKEKNDE KKEGTTPSRK EDDSRGNKSI DDDNFFRRIF KDKNEEKKGV AHDRNEGEKC
EEGDKENFFR KLFKDKDKHE DRRIEGLDKN DDDGKSTSGI EEEENSEFLS FRRLFRVHPE
DTKSGHIEGS QPNGISEGSP GSESFFKRLF RDREDSEILG SKLLKEARHL LLIFLSRHPD
PTGNSEKQSG KPPLPNNVLA ELRKGSYYAS LELVQSLCDT SYGLVDIFPV EDRKIALRES
LTEINSHIAS SEKNGGVCFP MGRGIYRVVH IPEDESVLLN SREKAPYLIC VEVLKAETPS
HSKGSSDVNK LSKGGIPLAN GDVQLPKPPP WAYPLWSRHE PQNYETDRML NSTSQVIDQA
MAQLWEAKVK FVNVSFSIER IGRSRSIAMS ESGRRIRQPT AESHNLSEDS QAVVDQPIEW
VKVTLSAVPG VNMEDVDDNE PTRKKDHRRV PSTIAMEEVK AAALKGEAPP GLPLKGVGQS
TQNLDPKATD GGDPKPTDAL AGELWTVKKE RIRRSSVHGK LPGWDLRSII VKSGDDCRQE
HLAVQLVAHF YDIYQEAGLP LWLRPYEVIV TSAYAALIET IPDTASIHSI KSRFPNILSL
RDYYVAKYEE NSPNFKLAQR NFVESMAGYS ILSYLLQVKD RHNGNLLIDE EGHIIHIDFG
FMLSNSPGGV MDSDAEGTPS EFFDYFKVLC IQGFLTCRKH AERVILLVEM LQDSGFPCFK
GGTRTILNLR KRFHLSLTEE QCVSLVLSLI SSSMDAWRTR QYDYYQRVLN GIL
//