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Database: UniProt
Entry: M8DGW6_9BACL
LinkDB: M8DGW6_9BACL
Original site: M8DGW6_9BACL 
ID   M8DGW6_9BACL            Unreviewed;       453 AA.
AC   M8DGW6;
DT   29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT   29-MAY-2013, sequence version 1.
DT   05-JUL-2017, entry version 30.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:EMT52697.1};
GN   ORFNames=I532_13609 {ECO:0000313|EMBL:EMT52697.1};
OS   Brevibacillus borstelensis AK1.
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Paenibacillaceae;
OC   Brevibacillus.
OX   NCBI_TaxID=1300222 {ECO:0000313|EMBL:EMT52697.1, ECO:0000313|Proteomes:UP000012081};
RN   [1] {ECO:0000313|EMBL:EMT52697.1, ECO:0000313|Proteomes:UP000012081}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AK1 {ECO:0000313|EMBL:EMT52697.1,
RC   ECO:0000313|Proteomes:UP000012081};
RA   Rajan I., PoliReddy D., Sugumar T., Rathinam K., Alqarawi S.,
RA   Khalil A.B., Sivakumar N.;
RT   "Assembly of a new bacterial strain Brevibacillus borstelensis AK1.";
RL   Submitted (MAR-2013) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:EMT52697.1}.
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DR   EMBL; APBN01000004; EMT52697.1; -; Genomic_DNA.
DR   RefSeq; WP_003388867.1; NZ_APBN01000004.1.
DR   EnsemblBacteria; EMT52697; EMT52697; I532_13609.
DR   PATRIC; fig|1300222.3.peg.2848; -.
DR   OrthoDB; POG091H02FF; -.
DR   Proteomes; UP000012081; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000012081};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897};
KW   Reference proteome {ECO:0000313|Proteomes:UP000012081}.
FT   DOMAIN      147    275       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      359    428       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     155    162       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   453 AA;  51007 MW;  E6FA951D55733C2F CRC64;
     MDAAISELWR KVLAKIEKSL SKPSFDTWLK ATKATTLEED ALIVVAPNDF ARDWLETRYS
     QLITDTLYEV TGVNMKVKFV AMQNPDAAFA DEQPAPRVKV SAPPSNGDDQ PPSILNPKYT
     FDTFVIGSGN RFAHAASLAV AEAPAKAYNP LFIYGGVGLG KTHLMHAIGH YVIQHNPSAK
     VVYLSSEKFT NEFINSIRDN KTVEFRNKYR SVDVLLIDDI QFLAGKEQTQ EEFFHTFNAL
     HEESKQIVIS SDRPPKEIPT LEDRLRSRFE WGLITDIQPP DLETRIAILR KKAKAENLDI
     PNEVMIYIAN QIDSNIRELE GALIRVVAYS SLINRDIDTQ LAAEALKDII PSSRPRVITI
     IDIQRAVGEE FNLKLEDFKA KKRTKSVAFP RQIAMYLSRE LTDASLPKIG DEFGGRDHTT
     VIHAHEKISR ALATDPQMQV TIQSLIEKLK ANH
//
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