ID M9LQD1_PSEA3 Unreviewed; 3127 AA.
AC M9LQD1;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 47.
DE SubName: Full=Ras GTPase activating protein RasGAP {ECO:0000313|EMBL:GAC74646.1};
GN ORFNames=PANT_12c00075 {ECO:0000313|EMBL:GAC74646.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC74646.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
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DR EMBL; DF196778; GAC74646.1; -; Genomic_DNA.
DR STRING; 1151754.M9LQD1; -.
DR OrthoDB; 1356198at2759; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProt.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR PANTHER; PTHR10194:SF142; NEUROFIBROMIN; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00616; RasGAP; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
PE 4: Predicted;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976}.
FT DOMAIN 1698..1891
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 110..265
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 389..423
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 452..528
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 13..32
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 33..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 110..132
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 158..193
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..216
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 217..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 455..477
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 506..520
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 3127 AA; 345910 MW; 392A5A61ACCB778E CRC64;
MPAEGPPRTE QAEPGEEEEE EEEEEEEEEE QQQQQQQQQQ ADWVQRQSTN NSMQPVHIDH
SALHTSLLRL LVSPRPPSSL VSTSSTSSAS RGIACIHSTY TPESSFTMDP YASASSSASP
LPPTSATASA STLEARAAAA ASSVHSPDLR RPGIGMLNGD TPSSSSPSHH HYHVSRPSQT
SQHSFQYQHQ HPHQLQHPHP HPHPQQHQHQ PHPHHHASNH SIGSSSGFRH DSTDSTLTPT
FSSNNLHNAS HNLFSDPSDP LSQPLNPANA APLAINASSH ILIASIVQRL VNKLPCNSGW
RLQLVEEDDL VRSCVANLIN LSCFQLGLVV KELLGAIELL VKQSSQQHLE QQAGIGMLHS
QLFILKILVS CLNHQWRIAA GHANSPRPGL DPLLSATTSH ANDASASSAA DSAHSWSDPP
AMDDTQAKHV LSVMTLLIKQ NVARDDATFS SIHDGGLDAR SSSKSDSTSS HTLSGRPPPS
ERSLRDLSLR DPASGFSSTK SFAHHTASRL TRDDSEQRED AASPTAGAAA EKLPEVFMPT
ALCLAASTSL YVLYPYFPPT RSPFDQPPTI DRADLAMGVG ADTQPSPASM PSTTTDAQID
PLQLTKGARF NSSSWTNTAF SPDVEGFDVP HHLQTRIYRL ASQVVFYLSS SNWVVVNARL
RNRLYYLSST IEDSPSTAEL RLLECSNFQR ARLASIIQEV STSFPQLKRS AQYTVALVLR
RAIWSWIQYH PAEFAALVTS NRRFEGSPDV VFDQVYALAD TTKRKIAFWP LLTSLLILCP
DVVGKAAVGE NRKASGSLAK KLSFIDGLRK SPRNTALIDV AALCCVDLFK AAATVPRSEN
GLRLIVQDLE VDLKERLFDP KRPLASGNKP IELMLMVDFF AALFRIDPQR TTRELVPICM
SESNPVHFKI ALVKAAVLLA SERYRLPWAP DVSILYPHIS RPLRAFFREM TYRLPRFDNR
DAARKRAASR AAASALFRTA SLSGSAAAAA ASLDELARLD LFQSTVQLWT LDVAALAHAI
DLDRPKALTS LSGGTTPFDR EKVLRNAVST DSLLSFTVSI CSVFATPPEF ACYRKISAAL
LSRVYHSGMF DDSLAEFCEH QRHVGVSLLP FFFTILTEQL MSSESSEMQR HYLELLRRSQ
QRRGFFISQE RDWETTAAAP FYPSAQERKL EYLWVQLVTL LLMCSSDTEV CSRAMQCAYG
HAQLTVGVTK YYDQLPDEWL RLYTDLADPN FLHTGRIAQQ KRIRALLRDI EEPSVAGWLA
WKEAYSRWAS LTQLVARPIV EDSSTAQDKA AQWHNYAGFL CAFGGACFAA SARITSEVEP
SVAQVLPQFS DLNEQPATLI EHFVQEMVDL LVSDSLWVRE KAKETLGVDL GPRLIGILFR
QIHAVLSDFF DKDTGYPKTS EMYTVFVEQS IGVATMVLHR LDEDKAVVAT SKVDIGSLMV
LFVEYANSLG RDEQALRIKT AMCQMCEALM RKKAAFSFSN ELRVRNRLFQ ALTTWTSDGS
EDGFHSNSLD ALDRLHRDLD VACLKCISIL LDKLPLLLAD DALLLDDKVE GAKTRHFAMY
FAYFIKILNR TRHSETAAVA RTRALNDARS LAGAKTGKVE SGRDFEPLRE SAILALSNLL
ASNIDSGLHS SLPLAYHEDP RIRTAFMQIM TNVLNQGTAF DELERLGGTR KCNRLIDLVC
QEDLQLALSV CQVCPGRDVE PMSVLLLSIF DAKGGLIRFL KAAVEEEIQR TATEEMVFRS
NSFCTTLLST FARTHGYDYL RSIMAPLITE FARKPAGFSV EMDPSRVEPG GSALKNQTAL
EEIAQAFIDA ICSSAHRVPA VLRELCRHIR NVLDTRFPAS RYQGVGGLMF LRFISPAVVS
PHMIDINLTG PSKDLRRGLV LISKILITLA SNNLFSSHKE PFMTGLNDFL KSNVWKVTAF
LDQVSDARTD PDRLYAADQP LGFGIHPTVY GIDERDQRML HKFLFEHVEK LGKCLSDRTS
KANELSTSGA GADRDSFLNG DAQWRRSHEA KNVYDDLCDA LATAGEPKAD ELPEPAFGAS
NYQDFLRRHA GRTVDEDSYR TIFYEGPSSR AGRPVLYYAM QNQKADTIDF EGLILYILQT
LETFAYRQFD LVFNTTACHP SNVTPSQWLL YFSSLVPASI LANVVNVFFL NPNTTARVEL
QFWSSSSYGD SSIKHEIADR MTSLQNVVSC TTLADIEMYV EPRNLALDKL TLAILDSTAE
MHFDQITMVW YYRSLTPVKF SIGGEYLQIT GLKQQEWLPN VSVHLNDVFH LSDIDDVRSI
SVRGDDNTFF LSCRNGAMNF VFNSRERSEV VQALRQAKAR VSKFRANNAV DRVLRPNDVP
GTLLNMAMLN ITSDDSALRL SAYNLLCALS TSFNFGASSA KKRLLSSRGL ALPANTMAFV
TDLSKDFAVA APGVTLEFLL SFFDGFERAA RSQKTVCLHY LSPWLSNLVM FVHTSREQQG
EYHRRIKEIL NQLISITTKQ PDMYAIMQRC VWSQLSRLDD LIPTFLDVFA EAAMDSGLHT
ERFEAVLDTM VSFASINLRG KLLSRLRKVI AKTAQNALVS QLHLNASWKE IATLVRMNMV
LSFTNRVEAL LYLPELLHVI LLLAGNGTDA TRHAIYGSAI NLVHSLCTED QREARKPEEA
TPRSAEAVAK LRALLERLAE PEALKLFGLP AASQATSTNA AFGASTEMVR DPPDNASIER
LALLMYEVAD AAAPSVDAAN SWRARLTSLV TSTAFQYNPI IQSRAFVLLG CLAQGEIDDD
LLYQILVSLR GSISEWASSS SDMPMISIVT CLSKVVRILP TRSRYLSQMI WLGVAMVQCG
HVPLFKAGAE LMLATVETIW QRGIPTSEGS DLIAYLLDAR FEFRELACKL DDETGVDFDI
NFSFGMAALL VKGLRHPSTK EVTTKLMRAM LHHCGVDASG ERCSSDGRIS ERQLGFFVGL
LPTATRSEEL GQLLALAGVE PDACEAAVDA RRSGYKGLQQ YLDVLNNRIA LLLVTLVTSL
LQHAESDAER LMLYGFLNEA AREMPAIVSI LYDSLAPSMK DVFVNCSNGA ILDAVHGIAQ
TALSQPFFAA QARETAKRGG PNAYLVESGY GSLLGCGAFV PLMEGRRHVL CKLSIQLVLG
LTDVGTT
//
