ID M9M0I4_PSEA3 Unreviewed; 1620 AA.
AC M9M0I4;
DT 29-MAY-2013, integrated into UniProtKB/TrEMBL.
DT 29-MAY-2013, sequence version 1.
DT 27-MAR-2024, entry version 40.
DE RecName: Full=MaoC-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=PANT_9d00080 {ECO:0000313|EMBL:GAC73385.1};
OS Pseudozyma antarctica (strain T-34) (Yeast) (Candida antarctica).
OC Eukaryota; Fungi; Dikarya; Basidiomycota; Ustilaginomycotina;
OC Ustilaginomycetes; Ustilaginales; Ustilaginaceae; Moesziomyces.
OX NCBI_TaxID=1151754 {ECO:0000313|EMBL:GAC73385.1, ECO:0000313|Proteomes:UP000011976};
RN [1] {ECO:0000313|Proteomes:UP000011976}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=T-34 {ECO:0000313|Proteomes:UP000011976};
RX PubMed=23558529; DOI=10.1128/genomea.00064-13;
RA Morita T., Koike H., Koyama Y., Hagiwara H., Ito E., Fukuoka T., Imura T.,
RA Machida M., Kitamoto D.;
RT "Genome sequence of the basidiomycetous yeast Pseudozyma antarctica T-34, a
RT producer of the glycolipid biosurfactants mannosylerythritol lipids.";
RL Genome Announc. 1:E0006413-E0006413(2013).
CC -!- PATHWAY: Lipid metabolism; fatty acid beta-oxidation.
CC {ECO:0000256|ARBA:ARBA00005005}.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}. Peroxisome
CC {ECO:0000256|ARBA:ARBA00004275}.
CC -!- SIMILARITY: Belongs to the short-chain dehydrogenases/reductases (SDR)
CC family. {ECO:0000256|ARBA:ARBA00006484}.
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DR EMBL; DF196775; GAC73385.1; -; Genomic_DNA.
DR STRING; 1151754.M9M0I4; -.
DR OrthoDB; 2140828at2759; -.
DR UniPathway; UPA00659; -.
DR Proteomes; UP000011976; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
DR GO; GO:0008324; F:monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0006635; P:fatty acid beta-oxidation; IEA:UniProtKB-UniPathway.
DR GO; GO:0098771; P:inorganic ion homeostasis; IEA:UniProt.
DR GO; GO:0030003; P:intracellular monoatomic cation homeostasis; IEA:UniProt.
DR CDD; cd03448; HDE_HSD; 1.
DR CDD; cd05353; hydroxyacyl-CoA-like_DH_SDR_c-like; 2.
DR Gene3D; 1.10.287.4290; -; 2.
DR Gene3D; 1.20.1510.10; Cation efflux protein transmembrane domain; 1.
DR Gene3D; 3.30.70.1350; Cation efflux protein, cytoplasmic domain; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR002524; Cation_efflux.
DR InterPro; IPR027470; Cation_efflux_CTD.
DR InterPro; IPR036837; Cation_efflux_CTD_sf.
DR InterPro; IPR027469; Cation_efflux_TMD_sf.
DR InterPro; IPR029069; HotDog_dom_sf.
DR InterPro; IPR002539; MaoC-like_dom.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020904; Sc_DH/Rdtase_CS.
DR InterPro; IPR002347; SDR_fam.
DR NCBIfam; TIGR01297; CDF; 1.
DR PANTHER; PTHR45024; DEHYDROGENASES, SHORT CHAIN; 1.
DR PANTHER; PTHR45024:SF2; SCP2 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF00106; adh_short; 2.
DR Pfam; PF01545; Cation_efflux; 1.
DR Pfam; PF01575; MaoC_dehydratas; 1.
DR Pfam; PF16916; ZT_dimer; 1.
DR PRINTS; PR00081; GDHRDH.
DR PRINTS; PR00080; SDRFAMILY.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF160240; Cation efflux protein cytoplasmic domain-like; 1.
DR SUPFAM; SSF161111; Cation efflux protein transmembrane domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 2.
DR PROSITE; PS00061; ADH_SHORT; 2.
PE 3: Inferred from homology;
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW NADP {ECO:0000256|ARBA:ARBA00022857};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW Peroxisome {ECO:0000256|ARBA:ARBA00023140};
KW Reference proteome {ECO:0000313|Proteomes:UP000011976};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 806..915
FT /note="MaoC-like"
FT /evidence="ECO:0000259|Pfam:PF01575"
FT DOMAIN 1544..1611
FT /note="Cation efflux protein cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF16916"
FT REGION 621..644
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 790..814
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 955..992
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1091..1114
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1177..1276
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..638
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1229
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1620 AA; 172580 MW; 84C36EBD8D075CB8 CRC64;
MSDFPSTENG KISFKNRVVV VTGAGNGLGR AYALFFASRG AKVLINDLGP SAKDKNKKAA
DVVVEEIQQA GGEAIANYDS NTDGEKVIQQ AIDKWGRIDI LINNAGILRD KSYFTDDRFF
AFRTNSFKAM SDKEWDQITA VHITGSYACA KAAWPHMRKQ KFGRIINTSS AAGIYGNFGQ
ANYAAAKHAM IGFGKTLAIE GAKYNILSNV LAPVAASQLT ATVMPPEMLE NLTPDYVVPI
VAYLVSAENK EVSGHVFECG AGFFAQVRRE RSRGVVFKTD DSFTPAAVRA KIDEILDFDE
KPEYPFRITD ANHMEFLERA KEAKSNDQGE GPVRFDGKTV LVTGAGAGLG RAYAHMFGKL
GANVVVNDFL EKNAAAVVDE IKKAGGKAAP AVGSVEDGEK IVKAAVDAFG SIHVIINNAG
ILRDKSFAAM SDQEWHAVLN THLRGTYSVC HAAWPIFQQQ KYGRIVNTTS AVGIYGNFGQ
ANYSTAKAGI IGFTNTLGIE GKKYNILANT IAPNAGTAMT ATIWPQEMVD AFKPDYVAPM
VGYLASEANE DLTSSLFEVS GGWVAAVRWQ RAGGHSFSHG KPPSPEKIVK KWSKITDYET
NPSWPTSPSD SLGDIVSNFG QEEEDEDDDD EGGAGGDYSD PEDPEIVQKA KKEPIEDSEF
SYGERDVILY NLGVGATEKD LDLVFEQDDD FRAVPTFGVI PQFMASGGIP LDWLPNFSPM
MLLHGEQYLA IKKPIPTSAT LVNKPKLMEV LDKGKAAAVT SVVHTFDKGS GDLVFESQST
VFIRGSGGFG GKKSGKDRGA ASAANKPPSR KADKVVTEKT TDAQAALYRL SGDYNPLHID
PSFAQVGGFD KPILHGLCSF GISGKHIFRE YGAYKDIKVR FTGHVFPGET LETSMWKEGN
KVIFTTRVVE RDTQALGAAA VTLADDTGTR LRWHHSSTHL EALFGSWTCA SDAPPGHHTS
VTKGPSEDVA HGPTAHPKPS SARVPPPSRC RSPPPIGLLL LLPMRLSSRS RSFLTTTTAG
KPLRSTPLAL ASIETRASTT RQPRKVVASS TARPQPPVVY ARFKSTHHPA HPTAVPTSPV
LPKPSHIAST LATEEARPPV AHPQPPPHQG PPRLVRYEAD SHAHPQHPLA LYPSSYSHAS
YPDPASYRAH LSNRRAPASL FGLFPSTSIT AASVKASSDP HAYPGAGPTI QTSITTPTQA
TSRPVAIDST APSDAMTASA SSIVDATKSG QAELHQRKKG AAAPASATAA AVATSKHSHS
HGHHGHHHGH DHGSPEEADK LLAALKGKGD RGSNITLAGL VSNVGLCGAK GVAGVYLNSA
ALLADAAHSL SDMFADLVTL FCWKMSQKPP SASHPLGYGK YETMGSLGVS LVLVAGAVGI
GFHSYGLLLE AIQPTLQHAP AAIQALSHFT GSIASAGGLL HDHHDHGAVA HGEGGVLDPN
AMWFALLSIA VKEWLYHATL KIAREENSSV LEANALHHRS DSLSSAVTFL AIGGSWLGFP
VLDPLGGLLV AGLIGKQGAD LLIGALGELS DRGVEPEILQ TLDQAIVEVQ KQNPLLLGWK
DLRAVKSGVS TFADVTLQLP NDATLHTASH IEAQVRAKIT AAVKGVKEVR VRLVTVDATN
//
