GenomeNet

Database: UniProt
Entry: M9MS87_DROME
LinkDB: M9MS87_DROME
Original site: M9MS87_DROME 
ID   M9MS87_DROME            Unreviewed;      2089 AA.
AC   M9MS87;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   27-SEP-2017, entry version 39.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|EMBL:ADV37710.1,
GN   ECO:0000313|FlyBase:FBgn0285944};
GN   Synonyms=bas {ECO:0000313|EMBL:ADV37710.1}, bss
GN   {ECO:0000313|EMBL:ADV37710.1}, Dmel\CG9907
GN   {ECO:0000313|EMBL:ADV37710.1}, DmNa[[V]]
GN   {ECO:0000313|EMBL:ADV37710.1}, DmNa[[v]]
GN   {ECO:0000313|EMBL:ADV37710.1}, DmNa[[v]]1
GN   {ECO:0000313|EMBL:ADV37710.1}, DmNav1 {ECO:0000313|EMBL:ADV37710.1},
GN   l(1)14Da {ECO:0000313|EMBL:ADV37710.1}, l(1)ESHS48
GN   {ECO:0000313|EMBL:ADV37710.1}, lincRNA.S9469
GN   {ECO:0000313|EMBL:ADV37710.1}, Ocd {ECO:0000313|EMBL:ADV37710.1}, olfD
GN   {ECO:0000313|EMBL:ADV37710.1}, par {ECO:0000313|EMBL:ADV37710.1}, sbl
GN   {ECO:0000313|EMBL:ADV37710.1}, sbl-1 {ECO:0000313|EMBL:ADV37710.1};
GN   ORFNames=CG9907 {ECO:0000313|EMBL:ADV37710.1,
GN   ECO:0000313|FlyBase:FBgn0285944}, Dmel_CG9907
GN   {ECO:0000313|EMBL:ADV37710.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084-RESEARCH0084(2002).
RN   [5] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:ADV37710.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE014298; ADV37710.1; -; Genomic_DNA.
DR   RefSeq; NP_001188628.1; NM_001201699.1.
DR   UniGene; Dm.22809; -.
DR   PaxDb; M9MS87; -.
DR   EnsemblMetazoa; FBtr0303683; FBpp0292700; FBgn0264255.
DR   GeneID; 32619; -.
DR   CTD; 32619; -.
DR   FlyBase; FBgn0285944; para.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   ChiTaRS; Prm; fly.
DR   GenomeRNAi; 32619; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0264255; -.
DR   ExpressionAtlas; M9MS87; differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    205    227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    285       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    779    802       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    823    840       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    852    876       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    907    929       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    987   1008       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1299   1321       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1327   1353       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1374   1405       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1492   1518       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1581   1599       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1611   1630       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1642   1661       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1705   1728       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1791   1814       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1835   1870       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      421    471       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2089 AA;  234749 MW;  41AC2FBFA24CA55A CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV IRYDDEDEDE
     GPQPDPTLEQ GVPIPVRLQG SFPPELASTP LEDIDPYYSN VLTFVVVSKG KDIFRFSASK
     AMWMLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST EVIFTGIYTF
     ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
     AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC IKKFPLDGSW
     GNLTDENWDY HNRNSSNWYS EDEGISFPLC GNISGAGQCD DDYVCLQGFG PNPNYGYTSF
     DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA GPWHMLFFIV IIFLGSFYLV NLILAIVAMS
     YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANAQ AQAAADAAAA EEAALHPEMA
     KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT TAHQATKVRK
     VSTYTIRNGR GRFGIPGSDR KPLVLSTYQD AQQHLPYADD SNAVTPMSEE NGAIIVPVYY
     GNLGSRHSSY TSHQSRISYT SHGDLLGGMA VMGVSTMTKE SKLRNRNTRN QSVGATNGGT
     TCLDTNHKLD HRDYEIGLEC TDEAGKIKHH DNPFIEPVQT QTVVDMKDVM VLNDIIEQAA
     GRHSRASDRG VSVYYFPTED DDEDGPTFKD KALEVILKGI DVFCVWDCCW VWLKFQEWVS
     LIVFDPFVEL FITLCIVVNT MFMAMDHHDM NKEMERVLKS GNYFFTATFA IEATMKLMAM
     SPKYYFQEGW NIFDFIIVAL SLLELGLEGV QGLSVLRSFR LLRVFKLAKS WPTLNLLISI
     MGRTMGALGN LTFVLCIIIF IFAVMGMQLF GKNYHDHKDR FPDGDLPRWN FTDFMHSFMI
     VFRVLCGEWI ESMWDCMYVG DVSCIPFFLA TVVIGNLVVL NLFLALLLSN FGSSSLSAPT
     ADNDTNKIAE AFNRIGRFKS WVKRNIADCF KLIRNKLTNQ ISDQPSGERT NQISWIWSEE
     HGDNELELGH DEILADGLIK KGIKEQTQLE VAIGDGMEFT IHGDMKNNKP KKSKYLNNAT
     DDDTASINSY GSHKNRPFKD ESHKGSAETM EGEEKRDASK EDLGLDEELD EEGECEEGPL
     DGDIIIHAHD EDILDEYPAD CCPDSYYKKF PILAGDDDSP FWQGWGNLRL KTFQLIENKY
     FETAVITMIL MSSLALALED VHLPQRPILQ DILYYMDRIF TVIFFLEMLI KWLALGFKVY
     FTNAWCWLDF VIVMVSLINF VASLVGAGGI QAFKTMRTLR ALRPLRAMSR MQGMRVVVNA
     LVQAIPSIFN VLLVCLIFWL IFAIMGVQLF AGKYFKCEDM NGTKLSHEII PNRNACESEN
     YTWVNSAMNF DHVGNAYLCL FQVATFKGWI QIMNDAIDSR EVDKQPIRET NIYMYLYFVF
     FIIFGSFFTL NLFIGVIIDN FNEQKKKAGG SLEMFMTEDQ KKYYNAMKKM GSKKPLKAIP
     RPRWRPQAIV FEIVTDKKFD IIIMLFIGLN MFTMTLDRYD ASDTYNAVLD YLNAIFVVIF
     SSECLLKIFA LRYHYFIEPW NLFDVVVVIL SILGLVLSDI IEKYFVSPTL LRVVRVAKVG
     RVLRLVKGAK GIRTLLFALA MSLPALFNIC LLLFLVMFIF AIFGMSFFMH VKEKSGINDV
     YNFKTFGQSM ILLFQMSTSA GWDGVLDAII NEEACDPPDN DKGYPGNCGS ATVGITFLLS
     YLVISFLIVI NMYIAVILEN YSQATEDVQE GLTDDDYDMY YEIWQQFDPE GTQYIRYDQL
     SEFLDVLEPP LQIHKPNKYK IISMDIPICR GDLMYCVDIL DALTKDFFAR KGNPIEETGE
     IGEIAARPDT EGYEPVSSTL WRQREEYCAR LIQHAWRKHK ARGEGGGSFE PDTDHGDGGD
     PDAGDPAPDE ATDGDAPAGG DGSVNGTAEG AADADESNVN SPGEDAAAAA AAAAAAAAAG
     TTTAGSPGAG SAGRQTAVLV ESDGFVTKNG HKVVIHSRSP SITSRTADV
//
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