GenomeNet

Database: UniProt
Entry: M9MSA0_DROME
LinkDB: M9MSA0_DROME
Original site: M9MSA0_DROME 
ID   M9MSA0_DROME            Unreviewed;      2099 AA.
AC   M9MSA0;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   22-NOV-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|EMBL:ADV37727.1,
GN   ECO:0000313|FlyBase:FBgn0285944};
GN   Synonyms=bas {ECO:0000313|EMBL:ADV37727.1}, bss
GN   {ECO:0000313|EMBL:ADV37727.1}, Dmel\CG9907
GN   {ECO:0000313|EMBL:ADV37727.1}, DmNa[[V]]
GN   {ECO:0000313|EMBL:ADV37727.1}, DmNa[[v]]
GN   {ECO:0000313|EMBL:ADV37727.1}, DmNa[[v]]1
GN   {ECO:0000313|EMBL:ADV37727.1}, DmNav1 {ECO:0000313|EMBL:ADV37727.1},
GN   l(1)14Da {ECO:0000313|EMBL:ADV37727.1}, l(1)ESHS48
GN   {ECO:0000313|EMBL:ADV37727.1}, lincRNA.S9469
GN   {ECO:0000313|EMBL:ADV37727.1}, Ocd {ECO:0000313|EMBL:ADV37727.1}, olfD
GN   {ECO:0000313|EMBL:ADV37727.1}, par {ECO:0000313|EMBL:ADV37727.1}, sbl
GN   {ECO:0000313|EMBL:ADV37727.1}, sbl-1 {ECO:0000313|EMBL:ADV37727.1};
GN   ORFNames=CG9907 {ECO:0000313|EMBL:ADV37727.1,
GN   ECO:0000313|FlyBase:FBgn0285944}, Dmel_CG9907
GN   {ECO:0000313|EMBL:ADV37727.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:ADV37727.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE014298; ADV37727.1; -; Genomic_DNA.
DR   RefSeq; NP_001188645.1; NM_001201716.1.
DR   UniGene; Dm.22809; -.
DR   PaxDb; M9MSA0; -.
DR   EnsemblMetazoa; FBtr0303700; FBpp0292717; FBgn0264255.
DR   GeneID; 32619; -.
DR   CTD; 32619; -.
DR   FlyBase; FBgn0285944; para.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   ChiTaRS; Prm; fly.
DR   GenomeRNAi; 32619; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0264255; -.
DR   ExpressionAtlas; M9MSA0; differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    134    161       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    205    227       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    239    257       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    263    285       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    395    417       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    792    815       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    836    853       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    865    889       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    920    942       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1000   1021       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1309   1331       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1337   1363       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1384   1415       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1502   1528       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1591   1609       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1621   1640       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1652   1671       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1715   1738       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1801   1824       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1845   1880       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      421    471       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2099 AA;  235446 MW;  02A5B1329569064D CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV IRYDDEDEDE
     GPQPDPTLEQ GVPIPVRLQG SFPPELASTP LEDIDPYYSN VLTFVVVSKG KDIFRFSASK
     AMWMLDPFNP IRRVAIYILV HPLFSLFIIT TILVNCILMI MPTTPTVEST EVIFTGIYTF
     ESAVKVMARG FILCPFTYLR DAWNWLDFVV IALAYVTMGI DLGNLAALRT FRVLRALKTV
     AIVPGLKTIV GAVIESVKNL RDVIILTMFS LSVFALMGLQ IYMGVLTQKC IKKFPLDGSW
     GNLTDENWDY HNRNSSNWYS EDEGISFPLC GNISGAGQCD DDYVCLQGFG PNPNYGYTSF
     DSFGWAFLSA FRLMTQDFWE DLYQLVLRAA GPWHMLFFIV IIFLGSFYLV NLILAIVAMS
     YDELQKKAEE EEAAEEEAIR EAEEAAAAKA AKLEERANAQ AQAAADAAAA EEAALHPEMA
     KSPTYSCISY ELFVGGEKGN DDNNKEKMSI RSVEVESESV SVIQRQPAPT TAHQATKVRK
     VSTTSLSLPG SPFNIRRGSR SSHKYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD
     DSNAVTPMSE ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK
     ESKLRNRNTR NQSVGATNGG TTCLDTNHKL DHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ
     TQTVVDMKDV MVLNDIIEQA AGRHSRASDR GEDDDEDGPT FKDKALEVIL KGIDVFCVWD
     CCWVWLKFQE WVSLIVFDPF VELFITLCIV VNTMFMAMDH HDMNKEMERV LKSGNYFFTA
     TFAIEATMKL MAMSPKYYFQ EGWNIFDFII VALSLLELGL EGVQGLSVLR SFRLLRVFKL
     AKSWPTLNLL ISIMGRTMGA LGNLTFVLCI IIFIFAVMGM QLFGKNYHDH KDRFPDGDLP
     RWNFTDFMHS FMIVFRVLCG EWIESMWDCM YVGDVSCIPF FLATVVIGNL VVLNLFLALL
     LSNFGSSSLS APTADNDTNK IAEAFNRIGR FKSWVKRNIA DCFKLIRNKL TNQISDQPSG
     KGVCRCISAE HGDNELELGH DEILADGLIK KGIKEQTQLE VAIGDGMEFT IHGDMKNNKP
     KKSKYLNNAT DDDTASINSY GSHKNRPFKD ESHKGSAETM EGEEKRDASK EDLGLDEELD
     EEGECEEGPL DGDIIIHAHD EDILDEYPAD CCPDSYYKKF PILAGDDDSP FWQGWGNLRL
     KTFQLIENKY FETAVITMIL MSSLALALED VHLPQRPILQ DILYYMDRIF TVIFFLEMLI
     KWLALGFKVY FTNAWCWLDF VIVMVSLINF VASLVGAGGI QAFKTMRTLR ALRPLRAMSR
     MQGMRVVVNA LVQAIPSIFN VLLVCLIFWL IFAIMGVQLF AGKYFKCEDM NGTKLSHEII
     PNRNACESEN YTWVNSAMNF DHVGNAYLCL FQVATFKGWI QIMNDAIDSR EVDKQPIRET
     NIYMYLYFVF FIIFGSFFTL NLFIGVIIDN FNEQKKKAGG SLEMFMTEDQ KKYYNAMKKM
     GSKKPLKAIP RPRWRPQAIV FEIVTDKKFD IIIMLFIGLN MFTMTLDRYD ASDTYNAVLD
     YLNAIFVVIF SSECLLKIFA LRYHYFIEPW NLFDVVVVIL SILGLVLSDI IEKYFVSPTL
     LRVVRVAKVG RVLRLVKGAK GIRTLLFALA MSLPALFNIC LLLFLVMFIF AIFGMSFFMH
     VKEKSGINDV YNFKTFGQSM ILLFQMSTSA GWDGVLDAII NEEACDPPDN DKGYPGNCGS
     ATVGITFLLS YLVISFLIVI NMYIAVILEN YSQATEDVQE GLTDDDYDMY YEIWQQFDPE
     GTQYIRYDQL SEFLDVLEPP LQIHKPNKYK IISMDIPICR GDLMYCVDIL DALTKDFFAR
     KGNPIEETGE IGEIAARPDT EGYEPVSSTL WRQREEYCAR LIQHAWRKHK ARGEGGGSFE
     PDTDHGDGGD PDAGDPAPDE ATDGDAPAGG DGSVNGTAEG AADADESNVN SPGEDAAAAA
     AAAAAAAAAG TTTAGSPGAG SAGRQTAVLV ESDGFVTKNG HKVVIHSRSP SITSRTADV
//
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