GenomeNet

Database: UniProt
Entry: M9MSD6_DROME
LinkDB: M9MSD6_DROME
Original site: M9MSD6_DROME 
ID   M9MSD6_DROME            Unreviewed;      2097 AA.
AC   M9MSD6;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   22-NOV-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|EMBL:ADV37719.1,
GN   ECO:0000313|FlyBase:FBgn0285944};
GN   Synonyms=bas {ECO:0000313|EMBL:ADV37719.1}, bss
GN   {ECO:0000313|EMBL:ADV37719.1}, Dmel\CG9907
GN   {ECO:0000313|EMBL:ADV37719.1}, DmNa[[V]]
GN   {ECO:0000313|EMBL:ADV37719.1}, DmNa[[v]]
GN   {ECO:0000313|EMBL:ADV37719.1}, DmNa[[v]]1
GN   {ECO:0000313|EMBL:ADV37719.1}, DmNav1 {ECO:0000313|EMBL:ADV37719.1},
GN   l(1)14Da {ECO:0000313|EMBL:ADV37719.1}, l(1)ESHS48
GN   {ECO:0000313|EMBL:ADV37719.1}, lincRNA.S9469
GN   {ECO:0000313|EMBL:ADV37719.1}, Ocd {ECO:0000313|EMBL:ADV37719.1}, olfD
GN   {ECO:0000313|EMBL:ADV37719.1}, par {ECO:0000313|EMBL:ADV37719.1}, sbl
GN   {ECO:0000313|EMBL:ADV37719.1}, sbl-1 {ECO:0000313|EMBL:ADV37719.1};
GN   ORFNames=CG9907 {ECO:0000313|EMBL:ADV37719.1,
GN   ECO:0000313|FlyBase:FBgn0285944}, Dmel_CG9907
GN   {ECO:0000313|EMBL:ADV37719.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:ADV37719.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE014298; ADV37719.1; -; Genomic_DNA.
DR   RefSeq; NP_001188637.1; NM_001201708.1.
DR   UniGene; Dm.22809; -.
DR   PaxDb; M9MSD6; -.
DR   EnsemblMetazoa; FBtr0303692; FBpp0292709; FBgn0264255.
DR   GeneID; 32619; -.
DR   CTD; 32619; -.
DR   FlyBase; FBgn0285944; para.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   ChiTaRS; Prm; fly.
DR   GenomeRNAi; 32619; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0264255; -.
DR   ExpressionAtlas; M9MSD6; differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    145    172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    790    813       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    834    851       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    863    887       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    918    940       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    998   1019       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1307   1329       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1335   1355       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1396   1419       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1500   1526       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1589   1607       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1619   1638       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1650   1669       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1713   1736       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1799   1822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1843   1878       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      432    482       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2097 AA;  235614 MW;  C45C6BF4C25C3A4D CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK
     EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK
     GKDIFRFSAS KAMWMLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES
     TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR
     TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
     CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDEGISFPL CGNISGAGQC DDDYVCLQGF
     GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL
     VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA
     AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP
     TTAHQATKVR KVSTYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD DSNAVTPMSE
     ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK ESKLRNRNTR
     NQSVGATNGG TTCLDTNHKL DHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ TQTVVDMKDV
     MVLNDIIEQA AGRHSRASDR GVSVYYFPTE DDDEDGPTFK DKALEVILKG IDVFCVWDCC
     WVWLKFQEWV SLIVFDPFVE LFITLCIVVN TMFMAMDHHD MNKEMERVLK SGNYFFTATF
     AIEATMKLMA MSPKYYFQEG WNIFDFIIVA LSLLELGLEG VQGLSVLRSF RLLRVFKLAK
     SWPTLNLLIS IMGRTMGALG NLTFVLCIII FIFAVMGMQL FGKNYHDHKD RFPDGDLPRW
     NFTDFMHSFM IVFRVLCGEW IESMWDCMYV GDVSCIPFFL ATVVIGNLVV LNLFLALLLS
     NFGSSSLSAP TADNDTNKIA EAFNRIGRFK SWVKRNIADC FKLIRNKLTN QISDQPSGKG
     VCRCISAEHG DNELELGHDE ILADGLIKKG IKEQTQLEVA IGDGMEFTIH GDMKNNKPKK
     SKYLNNATDD DTASINSYGS HKNRPFKDES HKGSAETMEG EEKRDASKED LGLDEELDEE
     GECEEGPLDG DIIIHAHDED ILDEYPADCC PDSYYKKFPI LAGDDDSPFW QGWGNLRLKT
     FQLIENKYFE TAVITMILMS SLALALEDVH LPQRPILQDI LYYMDRIFTV IFFLEMLIKW
     LALGFKVYFT NAWCWLDFVI VMLSLINLAA VWSGADDVPA FRSMRTLRAL RPLRAVSRWE
     GMKVVVNALV QAIPSIFNVL LVCLIFWLIF AIMGVQLFAG KYFKCEDMNG TKLSHEIIPN
     RNACESENYT WVNSAMNFDH VGNAYLCLFQ VATFKGWIQI MNDAIDSREV DKQPIRETNI
     YMYLYFVFFI IFGSFFTLNL FIGVIIDNFN EQKKKAGGSL EMFMTEDQKK YYNAMKKMGS
     KKPLKAIPRP RWRPQAIVFE IVTDKKFDII IMLFIGLNMF TMTLDRYDAS DTYNAVLDYL
     NAIFVVIFSS ECLLKIFALR YHYFIEPWNL FDVVVVILSI LGLVLSDIIE KYFVSPTLLR
     VVRVAKVGRV LRLVKGAKGI RTLLFALAMS LPALFNICLL LFLVMFIFAI FGMSFFMHVK
     EKSGINDVYN FKTFGQSMIL LFQMSTSAGW DGVLDAIINE EACDPPDNDK GYPGNCGSAT
     VGITFLLSYL VISFLIVINM YIAVILENYS QATEDVQEGL TDDDYDMYYE IWQQFDPEGT
     QYIRYDQLSE FLDVLEPPLQ IHKPNKYKII SMDIPICRGD LMYCVDILDA LTKDFFARKG
     NPIEETGEIG EIAARPDTEG YEPVSSTLWR QREEYCARLI QHAWRKHKAR GEGGGSFEPD
     TDHGDGGDPD AGDPAPDEAT DGDAPAGGDG SVNGTAEGAA DADESNVNSP GEDAAAAAAA
     AAAAAAAGTT TAGSPGAGSA GRQTAVLVES DGFVTKNGHK VVIHSRSPSI TSRTADV
//
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