GenomeNet

Database: UniProt
Entry: M9MSP1_DROME
LinkDB: M9MSP1_DROME
Original site: M9MSP1_DROME 
ID   M9MSP1_DROME            Unreviewed;      2079 AA.
AC   M9MSP1;
DT   26-JUN-2013, integrated into UniProtKB/TrEMBL.
DT   26-JUN-2013, sequence version 1.
DT   22-NOV-2017, entry version 41.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=para {ECO:0000313|EMBL:ADV37686.1,
GN   ECO:0000313|FlyBase:FBgn0285944};
GN   Synonyms=bas {ECO:0000313|EMBL:ADV37686.1}, bss
GN   {ECO:0000313|EMBL:ADV37686.1}, Dmel\CG9907
GN   {ECO:0000313|EMBL:ADV37686.1}, DmNa[[V]]
GN   {ECO:0000313|EMBL:ADV37686.1}, DmNa[[v]]
GN   {ECO:0000313|EMBL:ADV37686.1}, DmNa[[v]]1
GN   {ECO:0000313|EMBL:ADV37686.1}, DmNav1 {ECO:0000313|EMBL:ADV37686.1},
GN   l(1)14Da {ECO:0000313|EMBL:ADV37686.1}, l(1)ESHS48
GN   {ECO:0000313|EMBL:ADV37686.1}, lincRNA.S9469
GN   {ECO:0000313|EMBL:ADV37686.1}, Ocd {ECO:0000313|EMBL:ADV37686.1}, olfD
GN   {ECO:0000313|EMBL:ADV37686.1}, par {ECO:0000313|EMBL:ADV37686.1}, sbl
GN   {ECO:0000313|EMBL:ADV37686.1}, sbl-1 {ECO:0000313|EMBL:ADV37686.1};
GN   ORFNames=CG9907 {ECO:0000313|EMBL:ADV37686.1,
GN   ECO:0000313|FlyBase:FBgn0285944}, Dmel_CG9907
GN   {ECO:0000313|EMBL:ADV37686.1};
OS   Drosophila melanogaster (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=7227 {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803};
RN   [1] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=10731132; DOI=10.1126/science.287.5461.2185;
RA   Adams M.D., Celniker S.E., Holt R.A., Evans C.A., Gocayne J.D.,
RA   Amanatides P.G., Scherer S.E., Li P.W., Hoskins R.A., Galle R.F.,
RA   George R.A., Lewis S.E., Richards S., Ashburner M., Henderson S.N.,
RA   Sutton G.G., Wortman J.R., Yandell M.D., Zhang Q., Chen L.X.,
RA   Brandon R.C., Rogers Y.H., Blazej R.G., Champe M., Pfeiffer B.D.,
RA   Wan K.H., Doyle C., Baxter E.G., Helt G., Nelson C.R., Gabor G.L.,
RA   Abril J.F., Agbayani A., An H.J., Andrews-Pfannkoch C., Baldwin D.,
RA   Ballew R.M., Basu A., Baxendale J., Bayraktaroglu L., Beasley E.M.,
RA   Beeson K.Y., Benos P.V., Berman B.P., Bhandari D., Bolshakov S.,
RA   Borkova D., Botchan M.R., Bouck J., Brokstein P., Brottier P.,
RA   Burtis K.C., Busam D.A., Butler H., Cadieu E., Center A., Chandra I.,
RA   Cherry J.M., Cawley S., Dahlke C., Davenport L.B., Davies P.,
RA   de Pablos B., Delcher A., Deng Z., Mays A.D., Dew I., Dietz S.M.,
RA   Dodson K., Doup L.E., Downes M., Dugan-Rocha S., Dunkov B.C., Dunn P.,
RA   Durbin K.J., Evangelista C.C., Ferraz C., Ferriera S., Fleischmann W.,
RA   Fosler C., Gabrielian A.E., Garg N.S., Gelbart W.M., Glasser K.,
RA   Glodek A., Gong F., Gorrell J.H., Gu Z., Guan P., Harris M.,
RA   Harris N.L., Harvey D., Heiman T.J., Hernandez J.R., Houck J.,
RA   Hostin D., Houston K.A., Howland T.J., Wei M.H., Ibegwam C.,
RA   Jalali M., Kalush F., Karpen G.H., Ke Z., Kennison J.A., Ketchum K.A.,
RA   Kimmel B.E., Kodira C.D., Kraft C., Kravitz S., Kulp D., Lai Z.,
RA   Lasko P., Lei Y., Levitsky A.A., Li J., Li Z., Liang Y., Lin X.,
RA   Liu X., Mattei B., McIntosh T.C., McLeod M.P., McPherson D.,
RA   Merkulov G., Milshina N.V., Mobarry C., Morris J., Moshrefi A.,
RA   Mount S.M., Moy M., Murphy B., Murphy L., Muzny D.M., Nelson D.L.,
RA   Nelson D.R., Nelson K.A., Nixon K., Nusskern D.R., Pacleb J.M.,
RA   Palazzolo M., Pittman G.S., Pan S., Pollard J., Puri V., Reese M.G.,
RA   Reinert K., Remington K., Saunders R.D., Scheeler F., Shen H.,
RA   Shue B.C., Siden-Kiamos I., Simpson M., Skupski M.P., Smith T.,
RA   Spier E., Spradling A.C., Stapleton M., Strong R., Sun E.,
RA   Svirskas R., Tector C., Turner R., Venter E., Wang A.H., Wang X.,
RA   Wang Z.Y., Wassarman D.A., Weinstock G.M., Weissenbach J.,
RA   Williams S.M., WoodageT, Worley K.C., Wu D., Yang S., Yao Q.A., Ye J.,
RA   Yeh R.F., Zaveri J.S., Zhan M., Zhang G., Zhao Q., Zheng L.,
RA   Zheng X.H., Zhong F.N., Zhong W., Zhou X., Zhu S., Zhu X., Smith H.O.,
RA   Gibbs R.A., Myers E.W., Rubin G.M., Venter J.C.;
RT   "The genome sequence of Drosophila melanogaster.";
RL   Science 287:2185-2195(2000).
RN   [2] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537568;
RA   Celniker S.E., Wheeler D.A., Kronmiller B., Carlson J.W., Halpern A.,
RA   Patel S., Adams M., Champe M., Dugan S.P., Frise E., Hodgson A.,
RA   George R.A., Hoskins R.A., Laverty T., Muzny D.M., Nelson C.R.,
RA   Pacleb J.M., Park S., Pfeiffer B.D., Richards S., Sodergren E.J.,
RA   Svirskas R., Tabor P.E., Wan K., Stapleton M., Sutton G.G., Venter C.,
RA   Weinstock G., Scherer S.E., Myers E.W., Gibbs R.A., Rubin G.M.;
RT   "Finishing a whole-genome shotgun: release 3 of the Drosophila
RT   melanogaster euchromatic genome sequence.";
RL   Genome Biol. 3:RESEARCH0079-RESEARCH0079(2002).
RN   [3] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   GENOME REANNOTATION.
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537572; DOI=10.1186/gb-2002-3-12-research0083;
RA   Misra S., Crosby M.A., Mungall C.J., Matthews B.B., Campbell K.S.,
RA   Hradecky P., Huang Y., Kaminker J.S., Millburn G.H., Prochnik S.E.,
RA   Smith C.D., Tupy J.L., Whitfied E.J., Bayraktaroglu L., Berman B.P.,
RA   Bettencourt B.R., Celniker S.E., de Grey A.D., Drysdale R.A.,
RA   Harris N.L., Richter J., Russo S., Schroeder A.J., Shu S.Q.,
RA   Stapleton M., Yamada C., Ashburner M., Gelbart W.M., Rubin G.M.,
RA   Lewis S.E.;
RT   "Annotation of the Drosophila melanogaster euchromatic genome: a
RT   systematic review.";
RL   Genome Biol. 3:RESEARCH0083.1-RESEARCH0083.22(2002).
RN   [4] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537573;
RA   Kaminker J.S., Bergman C.M., Kronmiller B., Carlson J., Svirskas R.,
RA   Patel S., Frise E., Wheeler D.A., Lewis S.E., Rubin G.M.,
RA   Ashburner M., Celniker S.E.;
RT   "The transposable elements of the Drosophila melanogaster euchromatin:
RT   a genomics perspective.";
RL   Genome Biol. 3:RESEARCH0084.1-RESEARCH0084.20(2002).
RN   [5] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=12537574;
RA   Hoskins R.A., Smith C.D., Carlson J.W., Carvalho A.B., Halpern A.,
RA   Kaminker J.S., Kennedy C., Mungall C.J., Sullivan B.A., Sutton G.G.,
RA   Yasuhara J.C., Wakimoto B.T., Myers E.W., Celniker S.E., Rubin G.M.,
RA   Karpen G.H.;
RT   "Heterochromatic sequences in a Drosophila whole-genome shotgun
RT   assembly.";
RL   Genome Biol. 3:RESEARCH0085-RESEARCH0085(2002).
RN   [6] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=16110336; DOI=10.1371/journal.pcbi.0010022;
RA   Quesneville H., Bergman C.M., Andrieu O., Autard D., Nouaud D.,
RA   Ashburner M., Anxolabehere D.;
RT   "Combined evidence annotation of transposable elements in genome
RT   sequences.";
RL   PLoS Comput. Biol. 1:166-175(2005).
RN   [7] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569856; DOI=10.1126/science.1139815;
RA   Smith C.D., Shu S., Mungall C.J., Karpen G.H.;
RT   "The Release 5.1 annotation of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1586-1591(2007).
RN   [8] {ECO:0000313|EMBL:ADV37686.1, ECO:0000313|Proteomes:UP000000803}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Berkeley {ECO:0000313|Proteomes:UP000000803};
RX   PubMed=17569867; DOI=10.1126/science.1139816;
RA   Hoskins R.A., Carlson J.W., Kennedy C., Acevedo D., Evans-Holm M.,
RA   Frise E., Wan K.H., Park S., Mendez-Lago M., Rossi F., Villasante A.,
RA   Dimitri P., Karpen G.H., Celniker S.E.;
RT   "Sequence finishing and mapping of Drosophila melanogaster
RT   heterochromatin.";
RL   Science 316:1625-1628(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448,
CC       ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; AE014298; ADV37686.1; -; Genomic_DNA.
DR   RefSeq; NP_001188604.1; NM_001201675.1.
DR   UniGene; Dm.22809; -.
DR   PaxDb; M9MSP1; -.
DR   EnsemblMetazoa; FBtr0303659; FBpp0292676; FBgn0264255.
DR   GeneID; 32619; -.
DR   CTD; 32619; -.
DR   FlyBase; FBgn0285944; para.
DR   eggNOG; KOG2301; Eukaryota.
DR   eggNOG; ENOG410XNP6; LUCA.
DR   GeneTree; ENSGT00830000128242; -.
DR   OrthoDB; EOG091G00FK; -.
DR   ChiTaRS; Prm; fly.
DR   GenomeRNAi; 32619; -.
DR   Proteomes; UP000000803; Chromosome X.
DR   Bgee; FBgn0264255; -.
DR   ExpressionAtlas; M9MSP1; differential.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50222; EF_HAND_2; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000803};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000803};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    145    172       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    216    238       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    250    268       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    274    296       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    406    428       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    826    843       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    855    879       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    910    932       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    990   1011       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1289   1311       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1317   1343       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1364   1395       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1482   1508       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1571   1589       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1601   1620       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1632   1651       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1695   1718       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1781   1804       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN     1825   1860       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED      432    482       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2079 AA;  233576 MW;  909006095107ADF1 CRC64;
     MTEDSDSISE EERSLFRPFT RESLVQIEQR IAAEHEKQKE LERKRAEGEV PQYGRKKKQK
     EIRYDDEDED EGPQPDPTLE QGVPIPVRLQ GSFPPELAST PLEDIDPYYS NVLTFVVVSK
     GKDIFRFSAS KAMWMLDPFN PIRRVAIYIL VHPLFSLFII TTILVNCILM IMPTTPTVES
     TEVIFTGIYT FESAVKVMAR GFILCPFTYL RDAWNWLDFV VIALAYVTMG IDLGNLAALR
     TFRVLRALKT VAIVPGLKTI VGAVIESVKN LRDVIILTMF SLSVFALMGL QIYMGVLTQK
     CIKKFPLDGS WGNLTDENWD YHNRNSSNWY SEDEGISFPL CGNISGAGQC DDDYVCLQGF
     GPNPNYGYTS FDSFGWAFLS AFRLMTQDFW EDLYQLVLRA AGPWHMLFFI VIIFLGSFYL
     VNLILAIVAM SYDELQKKAE EEEAAEEEAI REAEEAAAAK AAKLEERANA QAQAAADAAA
     AEEAALHPEM AKSPTYSCIS YELFVGGEKG NDDNNKEKMS IRSVEVESES VSVIQRQPAP
     TTAHQATKVR KVSTYTIRNG RGRFGIPGSD RKPLVLSTYQ DAQQHLPYAD DSNAVTPMSE
     ENGAIIVPVY YGNLGSRHSS YTSHQSRISY TSHGDLLGGM AVMGVSTMTK ESKLRNRNTR
     NQSVGATNGG TTCLDTNHKL DHRDYEIGLE CTDEAGKIKH HDNPFIEPVQ TQTVVDMKDV
     MVLNDIIEQA AGRHSRASDR GEDDDEDGPT FKDKALEVIL KGIDVFCVWD CCWVWLKFQE
     WVSLIVFDPF VELFITLCIV VNTMFMAMDH HDMNKEMERV LKSGNYFFTA TFAIEATMKL
     MAMSPKYYFQ EGWNIFDFII VALSLLELGL EGVQGLSVLR SFRLLRVFKL AKSWPTLNLL
     ISIMGRTMGA LGNLTFVLCI IIFIFAVMGM QLFGKNYHDH KDRFPDGDLP RWNFTDFMHS
     FMIVFRVLCG EWIESMWDCM YVGDVSCIPF FLATVVIGNL VVLNLFLALL LSNFGSSSLS
     APTADNDTNK IAEAFNRIGR FKSWVKRNIA DCFKLIRNKL TNQISDQPSE HGDNELELGH
     DEILADGLIK KGIKEQTQLE VAIGDGMEFT IHGDMKNNKP KKSKYLNNAT DDDTASINSY
     GSHKNRPFKD ESHKGSAETM EGEEKRDASK EDLGLDEELD EEGECEEGPL DGDIIIHAHD
     EDILDEYPAD CCPDSYYKKF PILAGDDDSP FWQGWGNLRL KTFQLIENKY FETAVITMIL
     MSSLALALED VHLPQRPILQ DILYYMDRIF TVIFFLEMLI KWLALGFKVY FTNAWCWLDF
     VIVMVSLINF VASLVGAGGI QAFKTMRTLR ALRPLRAMSR MQGMRVVVNA LVQAIPSIFN
     VLLVCLIFWL IFAIMGVQLF AGKYFKCEDM NGTKLSHEII PNRNACESEN YTWVNSAMNF
     DHVGNAYLCL FQVATFKGWI QIMNDAIDSR EVDKQPIRET NIYMYLYFVF FIIFGSFFTL
     NLFIGVIIDN FNEQKKKAGG SLEMFMTEDQ KKYYNAMKKM GSKKPLKAIP RPRWRPQAIV
     FEIVTDKKFD IIIMLFIGLN MFTMTLDRYD ASDTYNAVLD YLNAIFVVIF SSECLLKIFA
     LRYHYFIEPW NLFDVVVVIL SILGLVLSDI IEKYFVSPTL LRVVRVAKVG RVLRLVKGAK
     GIRTLLFALA MSLPALFNIC LLLFLVMFIF AIFGMSFFMH VKEKSGINDV YNFKTFGQSM
     ILLFQMSTSA GWDGVLDAII NEEACDPPDN DKGYPGNCGS ATVGITFLLS YLVISFLIVI
     NMYIAVILEN YSQATEDVQE GLTDDDYDMY YEIWQQFDPE GTQYIRYDQL SEFLDVLEPP
     LQIHKPNKYK IISMDIPICR GDLMYCVDIL DALTKDFFAR KGNPIEETGE IGEIAARPDT
     EGYEPVSSTL WRQREEYCAR LIQHAWRKHK ARGEGGGSFE PDTDHGDGGD PDAGDPAPDE
     ATDGDAPAGG DGSVNGTAEG AADADESNVN SPGEDAAAAA AAAAAAAAAG TTTAGSPGAG
     SAGRQTAVLV ESDGFVTKNG HKVVIHSRSP SITSRTADV
//
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